A5002799408- Zebrafish Biomedical Research Applications
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Retinal Development and Disorders
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Developmental Biology and Gene Regulation
- Immune cells in cancer
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Genomics and Phylogenetic Studies
- Renal and related cancers
Max Delbrück Center
2020-2022
MRC Centre for Regenerative Medicine
2016-2017
Medical Research Council
2016-2017
University of Edinburgh
2016-2017
Zebrafish, a popular organism for studying embryonic development and modeling human diseases, has so far lacked systematic functional annotation program akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium created central repository store process zebrafish developmental genomic data. Our data coordination center ( https://danio-code.zfin.org ) combines total of 1,802 sets unpublished re-analyzed published data, which used improve existing...
In the developing embryo, hematopoietic stem cells (HSCs) emerge from aorta-gonad-mesonephros (AGM) region, but molecular regulation of this process is poorly understood. Recently, progression E9.5 to E10.5 and polarity along dorso-ventral axis have been identified as clear demarcations supportive HSC niche. To identify novel secreted regulators maturation, we performed RNA sequencing over these spatiotemporal transitions in AGM region OP9 cell line. Screening several proteins through an ex...
Abstract Zebrafish, a popular model for embryonic development and modelling human diseases, has so far lacked systematic functional annotation programme akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium created first central repository store process zebrafish developmental genomic data. Our Data Coordination Center ( https://danio-code.zfin.org ) combines total of 1,802 sets unpublished reanalysed published genomics data, which used...
DNA accessibility of cis regulatory elements (CREs) dictates transcriptional activity and drives cell differentiation during development. While many the genes that regulate embryonic development have been described, underlying CRE dynamics controlling their expression remain largely unknown. To address this, we applied single-cell combinatorial indexing ATAC-seq (sci-ATAC-seq) to whole 24 hours post fertilization (hpf) stage zebrafish embryos developed a new computational tool, ScregSeg,...