A5080623461- Neuroscience of respiration and sleep
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
Florey Institute of Neuroscience and Mental Health
2016-2024
Integration and modulation of primary afferent sensory information begins at the first terminating sites within CNS, where central inhibitory circuits play an integral role. Viscerosensory is conveyed to nucleus solitary tract (NTS) it initiates neuroendocrine, behavioral, autonomic reflex responses that ensure optimal internal organ function. This excitatory input modulated by diverse, local interneurons, whose functions are not clearly understood. Here we show that, in male rats, 65%...
Abstract The nucleus of the solitary tract (NTS) receives direct viscerosensory vagal afferent input that drives autonomic reflexes, neuroendocrine function and modulates behaviour. A subpopulation NTS neurons project to accumbens (NAc); however, this NTS‐NAc pathway remains unknown. combination neuroanatomical tracing, slice electrophysiology fibre photometry was used in mice and/or rats determine how fit within network. projection are predominantly located medial caudal portions with 54 ±...
Inhibitory input at the solitary tract nucleus (NTS) is thought to alter autonomic reflex performance. Somatostatin (SOM) neurons are a class of inhibitory interneuron within central nervous system and present NTS. Here we aimed quantify impact inhibition had on vicerosensory signal throughput Using SOM‐Channel rhodopsin 2‐YFP mouse model, took whole cell recordings from NTS in horizontal brain stem slices that contained both (ST). This model allowed specific activation SOM network via ChR2....