A5023839176- Metabolism and Genetic Disorders
- Gut microbiota and health
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Open Source Software Innovations
- Business Strategy and Innovation
- RNA modifications and cancer
- Birth, Development, and Health
University of North Texas Health Science Center
2020-2023
University of North Texas
2020-2023
Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism primarily treated through a phenylalanine-restrictive diet that frequently supplemented with amino acid formula to maintain proper nutrition. Little known the effects these dietary interventions on gut microbiome PKU patients, particularly in adults. In this study, we sequenced V4 region 16S rRNA gene from stool samples collected adults (n = 11) and non-PKU controls 21). Gut bacterial communities were characterized...
The effects of synthetic, free-amino acid diets, similar to those prescribed as supplements for (phenylketonuria) PKU patients, on gut microbiota and overall health are not well understood. In the current, multidisciplinary study, we examined a synthetically-derived, low-fiber, amino diet behavior, cognition, microbiome composition, inflammatory markers. A cohort 20 male C57BL/6J mice were randomly assigned either standard or synthetic (n = 10) at post-natal day 21 maintained 13 weeks....
Abstract The Pah enu2 mutation in C57BL/6J mice is a well characterized model for studying phenylketonuria (PKU), with homozygotes displaying heightened blood phenylalanine and other characteristics of PKU. homozygous females do not successfully rear young on any conventional diet due to their disease status. most commonly used successful breeding strategy crossing heterozygous mutant males; producing litters 50% animals. In many treatment studies the pups produced are useable, but add...