A5100763651- Biosensors and Analytical Detection
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Gout, Hyperuricemia, Uric Acid
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Machine Learning in Bioinformatics
- Bioactive Compounds and Antitumor Agents
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- Pharmaceutical Quality and Counterfeiting
- Natural product bioactivities and synthesis
- Pharmacological Effects and Assays
- RNA and protein synthesis mechanisms
- Liver physiology and pathology
- Alcohol Consumption and Health Effects
- Lung Cancer Research Studies
- DNA and Nucleic Acid Chemistry
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Case Reports on Hematomas
- Angiogenesis and VEGF in Cancer
- Protein Structure and Dynamics
- Synthesis and biological activity
Ningbo University
2023-2024
Southern Medical University
2015-2024
Zhujiang Hospital
2024
Affiliated Hospital of Hebei University
2024
Dalian Maritime University
2022
Sun Yat-sen University
2005-2021
National Center for Drug Screening
2012
First Hospital of China Medical University
2011
China Medical University
2011
Tianjin University
2004-2006
Hepatic ischemia/reperfusion injury (HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development injury. Herein, we investigated the potential contribution gut microbes to HIRI. Ischemia/reperfusion surgery was performed establish murine model 16S rRNA gene sequencing metabolomics were used for microbial analysis. Transcriptomics proteomics analysis employed study host cell responses. Our...
In recent years, phosphodiesterase type 5 enzyme inhibitors, including tadalafil, sildenafil, and their analogues have emerged as illegal ingredients in dietary supplements. It can cause serious clinical side effects consumers, resulting diverse symptoms. To rapidly screen drugs supplements, a dual-labeled probe time-resolved fluorescence immunochromatography assay (DL-TRFICA) based on two broad-spectrum antibodies labeled with fluorescent microspheres was established for the simultaneous...
Anti-renal cell carcinoma (RCC) agents with new mechanisms of action are urgently needed. Twenty-seven natural products the piericidin class, including 17 ones, obtained from a marine-derived Streptomyces strain, and several them show strong inhibitory activities against ACHN renal cells. By exploring two representative compounds, A (PA) glucopiericidin (GPA), peroxiredoxin 1 (PRDX1) is detected as potential target by transcriptome data PA-treated cells, well paired RCC tumor versus adjacent...
Florfenicol (FF), with its broad-spectrum antibacterial activity, is frequently abused in the livestock and poultry industries has aroused growing public concern. Owing to structural similarities varying maximum residue limits between florfenicol other chloramphenicol (CAP)-type antibiotics, including thiamphenicol (TAP) (CAP), there an urgent need for a rapid effective immunoassay method distinguish them, order minimize risk of false positives. Fortunately, highly specific monoclonal...
Background: The purpose of this study was to develop folate-poly (PEG-cyanoacrylate-co-cholesteryl cyanoacrylate) (FA-PEG-PCHL)-modified freeze-dried liposomes for targeted chemotherapy using docetaxel as a model drug. Methods: FA-PEG-PCHL synthesized and its cytotoxicity evaluated by CCK-8 assay in L929. Docetaxel-loaded modified were prepared an organic solvent injection method lyophilized obtain FA-PEG-PCHL-docetaxel (FA-PDCT-L). Two carcinoma cell lines (MCF-7 A-549 cells) cultured with...
Mollugin, a kind of naphthohydroquinone, is major constituent isolated from Rubia cordifolia L. and demonstrated to possess anti-inflammatory activity in recent reports. However, the effects mechanism action mollugin inflammation have not been fully defined. The present study was therefore designed investigate whether suppresses inflammatory response lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Mollugin attenuated LPS-induced expression nitric oxide (NO), inducible synthase...
With regular influenza epidemics and the prevalence of drug-resistant virus strains, it is extremely crucial to develop effective low-toxicity anti-influenza A drugs that act on conserved sites novel targets. Here, we found a new compound, 1,3-dihydroxy-6-benzo[c]chromene (D715-2441), from library 8026 small-molecule compounds by cell-based MTT assay explored underlying mechanisms. Our results revealed D715-2441 possessed antiviral activities against multiple subtypes viruses (IAVs)...