A5009310546- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Pharmacology and Obesity Treatment
- Urinary Bladder and Prostate Research
- Muscle metabolism and nutrition
- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Pharmacological Effects and Assays
- Neuropeptides and Animal Physiology
- Menopause: Health Impacts and Treatments
- Receptor Mechanisms and Signaling
- Sexuality, Behavior, and Technology
- Pelvic floor disorders treatments
- Hypothalamic control of reproductive hormones
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Healthcare and Venom Research
- Doping in Sports
- DNA and Nucleic Acid Chemistry
- Menstrual Health and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Nitric Oxide and Endothelin Effects
- Phytoestrogen effects and research
- Effects and risks of endocrine disrupting chemicals
Boston University
2015-2024
University School
2015-2024
Bayer (Germany)
2002-2023
Augenstern
2020
University Medical Center
1991-2019
Boston Medical Center
1991-2019
Klinik und Poliklinik für Urologie
2014
Biostatistical Consulting (United States)
2013
International Society of Nephrology
2011
Brown University
2011
Expression of nuclear factor-kappaB (NF-kappaB)/Rel transcription factors has recently been found to promote cell survival, inhibiting the induction apoptosis. In most cells other than B lymphocytes, NF-kappaB/Rel is inactive, sequestered in cytoplasm. For example, extracts from two human untransformed breast epithelial lines expressed only very low levels NF-kappaB. Unexpectedly, tumor displayed significant NF-kappaB/Rel. Direct inhibition this NF-kappaB/ Rel activity cancer induced High...
Collagen synthesis has been examined in primary cultures of human corpus cavernosum smooth muscle cells (HCCSMC), the major mesenchymal cell type cavernosum. These were grown from surgical specimens and characterized by morphological biochemical characteristics. express mRNA for transforming growth factor-beta 1 (TGF-beta 1), a regulator extracellular matrix synthesis, as well all three subtypes TGF-beta receptors. Human primarily synthesize types I III fibrillar collagen. Treatment HCCSMC...
Aim The goal of this study was to determine if long-term testosterone (T) therapy in men with hypogonadism, henceforth referred as deficiency (TD), ameliorates or improves metabolic syndrome (MetS) components. Methods We performed a cumulative registry 255 men, aged between 33 and 69 years (mean 58.02 ± 6.30) subnormal plasma total T levels (mean: 9.93 1.38; range: 5.89–12.13 nmol/l) well at least mild symptoms TD assessed by the Aging Males' scale. All received treatment parenteral...
Prostatic membranes contain high affinity [dissociation constant (KD) = 1.16 nM], saturable binding sites for [125I]iodo-epidermal growth factor (EGF). The of [125I] iodo-EGF is specific since it displaced by excess EGF but not insulin, fibroblast factor, platelet-derived or multiplication-stimulating activity. Affinity labeling with [125I]iodo-EGF and subsequent cross-linking disuccinimidyl suberate demonstrated the to a macromolecule mol wt 170,000. Castration mature rats resulted in 3-...
This study analyzed the effects of normalization serum testosterone (T) levels on anthropometric parameters in hypogonadal men.Open-label, single-center, cumulative, prospective registry 255 men (aged 33-69 years, mean 58.02 ± 6.30 years), with T below 12.13 nmol/L (mean: 9.93±1.38). 215 for at least 2 182 3 148 4, and 116 5 years were studied. They received parenteral undecanoate 1,000 mg/12 weeks after an initial interval 6 weeks.Body weight (BW) decreased from 106.22 16.93 kg to 90.07...
The objective of this consensus document is to broaden the perspective on clinical management genitourinary syndrome menopause include androgens.A modified Delphi method was used reach among 14 international panelists representing multiple disciplines and societies.Menopause-related symptoms affect over 50% midlife older women. These have a marked impact sexual functioning, daily activities, emotional well-being, body image, interpersonal relations. Tissues in system are both androgen...
Objectives: In the absence of large, prospective, placebo-controlled studies longer duration, substantial evidence regarding safety and risk testosterone (T) therapy (TTh) with regard to cardiovascular (CV) outcomes can only be gleaned from observational studies. To date, there are limited comparing effects long-term TTh in men hypogonadism who were treated or remained untreated T, for obvious reasons. We have established a registry assess effectiveness T urological setting. Here, we sought...