A5078162124- Pulmonary Hypertension Research and Treatments
- Silicon Carbide Semiconductor Technologies
- Aluminum Alloys Composites Properties
- Advanced ceramic materials synthesis
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Silicon and Solar Cell Technologies
- Heat shock proteins research
- Hippo pathway signaling and YAP/TAZ
- Genomics, phytochemicals, and oxidative stress
- Advancements in Battery Materials
- Circular RNAs in diseases
- Advanced Battery Materials and Technologies
- Cardiovascular Disease and Adiposity
- Induction Heating and Inverter Technology
- Mitochondrial Function and Pathology
- Advanced Battery Technologies Research
- Redox biology and oxidative stress
- 14-3-3 protein interactions
- Caveolin-1 and cellular processes
- Hydrogen's biological and therapeutic effects
- Calpain Protease Function and Regulation
- Cardiac Fibrosis and Remodeling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Shandong University
2018-2024
State Key Laboratory of Crystal Materials
2024
Shandong First Medical University
2020-2023
Shandong Provincial Hospital
2018-2023
Hong Kong Polytechnic University
2023
Cardiac ischemia-reperfusion (I/R) injury results mainly from mitochondrial dysfunction and cardiomyocyte death. Mitophagy sustains function exerts a pro-survival effect on the reperfused heart tissue. Mammalian STE20-like kinase 1 (Mst1) regulates chronic cardiac metabolic damage autophagic activity, but its role in acute I/R injury, especially mitophagy, is unknown. The aim of this study to explore whether Mst1 involved reperfusion-mediated death via modulation FUN14 domain containing...
Abstract Equipping thin lithium metal anodes (LMAs) in batteries (LMBs) is essential to realize a high energy density of the battery. However, cycling stability LMAs, especially at depth discharge (DOD), very poor. Here, rapid preparation stable and LMAs through selective wetting molten (Li) on Janus structured conductive textile reported, which yields Li (∼3.0 mg cm −2 ) coating one side framework. This Li‐textile composite anode not only significantly reduces use by 80% comparison...
Context: Yes-associated protein (Yap) has been linked to several cardiovascular disorders, but the role of this in septic cardiomyocytes is not fully understood.Objective: The aim our study was explore influence Yap cardiomyopathy vivo and vitro.Materials methods: In current study, transgenic mice adenovirus-mediated gain-of-function assays were used an LPS-established model. Mitochondrial function mitochondrial fission determined through western blotting, immunofluorescence analysis...
Abstract Background Bone marrow mesenchymal stem cell (BM-MSC) has been shown to treat pulmonary arterial hypertension (PAH). However, excessive reactive oxygen species (ROS) increases the apoptosis of BM-MSCs, leading poor survival and engraft efficiency. Thus, improving ability BM-MSCs scavenge ROS may considerably enhance effectiveness transplantation therapy. Mammalian Ste20-like kinase 1 (Mst1) is a pro-apoptotic molecule which production. The aim this study uncover underlying...
Object: This study analyses the changes of pulmonary arterial elastin expression inhibited by hydrogen sulfide (H2S) in rats with hypoxic hypertension.Method: The research used 30 healthy and randomly divided them into control group, hypoxia + sodium hydrosulfide group. Each group contains 10 samples. right catheterization was selected to measure mean artery pressure (mPAP). RV/LV S ratio calculated through separating ventricle left plus interventricular septum. Optical microscopy observe...
Ferroptosis can induce low retention and engraftment after mesenchymal stem cell (MSC) delivery, which is considered a major challenge to the effectiveness of MSC-based pulmonary arterial hypertension (PAH) therapy. Interestingly, cystathionine γ-lyase (CSE)/hydrogen sulfide (H2S) pathway may contribute mediating ferroptosis. However, influence CSE/H2S on ferroptosis in human umbilical cord MSCs (HUCMSCs) remains unclear.To clarify whether effect HUCMSCs vascular remodelling PAH mice...
Carbonic anhydrase 1 (CA1)/kininogen and selenoprotein W (SelW)/14-3-3η signal transduction orchestrate oxidative stress, which can also be regulated by nitric oxide (NO). The mutated caveolin-1 (Cav-1F92A) gene may enhance NO production. This study explored the effect of Cav-1F92A-modified rat bone marrow mesenchymal stem cells (rBMSC/Cav-1F92A) on stress regulation through CA1/kininogen SelW/14-3-3η in a model monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH). PAH was...
The low survival rate of mesenchymal stem cells (MSCs) caused by anoikis, a form apoptosis, limits the therapeutic efficacy MSCs. As proapoptotic molecule, mammalian Ste20-like kinase 1 (Mst1) can increase production reactive oxygen species (ROS), thereby promoting anoikis. Recently, we found that Mst1 inhibition could protect mouse bone marrow MSCs (mBMSCs) from H2O2-induced cell apoptosis inducing autophagy and reducing ROS production. However, influence on anoikis in mBMSCs remains...
The aim of the present study was to investigate protective role hyperoxia liquid in regulating cardiopulmonary bypass (CPB)‑induced myocardial damage and its possible underlying mechanism. In CPB‑induced rat model, enhanced left ventricular ejection fraction (LVEF), reduced internal dimension systole (LVIDs) level, inhibited malondialdehyde levels, increased superoxide dismutase, glutathione (GSH) GSH peroxidase suppressed heart cell apoptosis, induced nuclear factor erythroid 2‑related 2...
Abstract BACKGROUND: Lost of adhesion the mesenchymal stem cell (MSC) to extracellular matrix (i.e., anoikis) caused poor survival, which limited therapeutic efficacy MSCs. We recently found that suppression mammalian sterile 20-like kinase 1 (Mst1) protected mouse bone marrow MSCs (mBMSCs) from ROS-mediated apoptosis. However, effect Mst1 inhibition on anoikis mBMSCs remains elusive. METHODS: propose use poly-HEMA-induced following silencing in mBMSCs, then were tested by Anoikis Assay Kit...
Abstract BackgroundBone marrow mesenchymal stem cell (BM-MSC) has been shown to treat pulmonary arterial hypertension (PAH). However, excessive reactive oxygen species (ROS) increases the apoptosis of BM-MSCs, leading poor survival and engraft efficiency. Thus, improving ability BM-MSCs scavenge ROS may considerably enhance effectiveness transplantation therapy. Mammalian Ste20-like kinase 1 (Mst1) is a pro-apoptotic molecule which production. The aim this study uncover underlying mechanisms...
Abstract Background: Bone marrow mesenchymal stem cell (BM-MSC) has been shown to treat pulmonary arterial hypertension (PAH). However, excessive reactive oxygen species (ROS) increases the apoptosis of BM-MSCs, leading poor survival and engraft efficiency. Thus, improving ability BM-MSCs scavenge ROS may considerably enhance effectiveness transplantation therapy. Mammalian Ste20-like kinase 1 (Mst1) is a pro-apoptotic molecule which production. The aim this study uncover whether Mst1...
Abstract Background Bone marrow mesenchymal stem cell (BM-MSC) has been shown to treat pulmonary arterial hypertension (PAH). However, excessive reactive oxygen species (ROS) increases the apoptosis of BM-MSCs, leading poor survival and engraft efficiency. Thus, improving ability BM-MSCs scavenge ROS may considerably enhance effectiveness transplantation therapy. Mammalian Ste20-like kinase 1 (Mst1) is a pro-apoptotic molecule which production. The aim this study uncover whether Mst1...