A5107977712- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Kidney Injury Research
- Cardiovascular Function and Risk Factors
- Macrophage Migration Inhibitory Factor
- Nitric Oxide and Endothelin Effects
- Vasculitis and related conditions
- Infant Nutrition and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Apelin-related biomedical research
- GDF15 and Related Biomarkers
- Clinical Nutrition and Gastroenterology
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Selenium in Biological Systems
The University of Sydney
2021-2025
Liaquat University of Medical & Health Sciences
2024
Universitätsmedizin Göttingen
2012
Selenium (Se) is linked to physiological homeostasis. Male mice (n = 8/group) were fed control (AIN93G) or diets enriched in sodium selenite (NaSe, 5.6 ppm), methylselenocysteine (Met, 4.7 diphenyl diselenide (DPDS, 14.2 nanoselenium (NanoSe, 2.7 ppm); dietary Se ascertained by inductively-coupled plasma mass spectrometry. At 4 weeks testes, sperm, thyroids, blood and stool collected assess histoarchitecture, circulating hormones (thyroxine, T4; triiodothyronine, T3; thyroid stimulating...
Intracellular redox imbalance in endothelial cells (EC) can lead to dysfunction, which underpins cardiovascular diseases (CVD). The acute phase serum amyloid A (SAA) elicits inflammation through stimulating production of reactive oxygen species (ROS). cyclic nitroxide 4-MethoxyTEMPO (4-MetT) is a superoxide dismutase mimetic that suppresses oxidant formation and inflammation. aim this study was investigate whether 4-MetT inhibits SAA-mediated activation cultured primary human aortic EC...
Acute serum amyloid A (SAA) is an apolipoprotein that mediates pro-inflammatory and pro-atherogenic pathways. SAA-mediated signalling diverse includes canonical acute immunoregulatory pathways in a range of cell types organs. This study aimed to further elucidate the roles for SAA pathogenesis vascular renal dysfunction. Two groups male ApoE-deficient mice were administered (100 µL, 120 µg/mL) or vehicle control µL PBS) monitored 4 16 weeks after treatment; tissue was harvested biochemical...
Acute-phase serum amyloid A (SAA) can disrupt vascular homeostasis and is elevated in subjects with diabetes, cardiovascular disease, rheumatoid arthritis. Cyclic nitroxides (e.g., Tempo) are a class of piperidines that inhibit oxidative stress inflammation. This study examined whether 4-methoxy-Tempo (4-MetT) inhibits SAA-mediated renal dysfunction. Acetylcholine-mediated relaxation aortic guanosine-3′,5′-cyclic monophosphate (cGMP) levels both diminished the presence SAA. 4-MetT...
Introduction: Lactoferrin (Ltf) is a monomeric glycoprotein which present in different body fluids including serum. Multifunctional healing abilities of Ltf have been documented huge number publications mainly the last three decades but no single study has conclusively described serum sources this protein particularly during acute phase reaction (APR). In current work role liver as source was investigated an induced APR.