A5089786247- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Pharmacogenetics and Drug Metabolism
- Pharmacology and Obesity Treatment
- Health, Medicine and Society
- Diabetes Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Pain Management and Opioid Use
- Epilepsy research and treatment
- Central Venous Catheters and Hemodialysis
- Anesthesia and Pain Management
- Cardiovascular Syncope and Autonomic Disorders
- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Pneumocystis jirovecii pneumonia detection and treatment
- Healthcare Systems and Practices
- Pain Mechanisms and Treatments
- Diagnosis and Treatment of Venous Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Enhanced Recovery After Surgery
- Treatment of Major Depression
- Drug Transport and Resistance Mechanisms
- Sleep and related disorders
Générale de Santé
2019-2022
Université Paris Cité
2011-2021
Inserm
2011-2021
Hôpital Lariboisière
2011-2020
Hôpital Fernand-Widal
2017-2019
Hôpital Privé Jacques Cartier
2019
University Hospital of Geneva
2015-2018
Hôpital Beau-Séjour
2018
Assistance Publique – Hôpitaux de Paris
2008-2017
Délégation Paris 7
2013-2017
Little is known on patterns of change over time in body composition, especially lean mass (LBM), during massive weight loss after Roux-en-Y gastric bypass (RYGB) obese patients. We performed sequential measurements total and regional composition patients RYGB, we compared a subsample surgery to nonsurgical control group similar age fatness. used dual-energy X-ray absorptiometry (DXA) before at 3, 6, 12 months RYGB 42 women (before surgery: 39.5 +/- 11.6 years; BMI 44.6 6.1 kg/m(2); mean...
The frequency of chronic postsurgical pain (CPSP) after knee replacement remains high, but might be decreased by improvements to prevention.To identify pre- and factors predictive CPSP 6 months replacement.Single-center prospective observational study.An orthopedic unit in a French hospital.Consecutive patients referred for total or unicompartmental arthroplasty from March July 2013 were prospectively invited participate this study. For each patient, we recorded preoperative intensity,...
Abstract Background Despite the development of multimodal analgesia for postoperative pain management, opioids are still required effective relief after knee arthroplasty. We aimed to identify determinants post‐operative intensity and opioid requirement in this context. Methods In observational prospective study, we recorded patient characteristics, pre‐operative intensity, anxiety depression levels, sensitivity thresholds response an electrical stimulus, mu‐opioid receptor ( OPRM 1)...
Several studies have focused on the clinical and biological characteristics of meningitis in order to distinguish between bacterial viral emergency setting. However, little is known about etiologies outcomes aseptic patients admitted Internal Medicine. The aim study describe etiologies, characteristics, with or without encephalitis adults an Medicine Department. A retrospective cohort was conducted Department Lariboisière Hospital Paris, France, from January 2009 December 2011. Clinical were...
Protein expression levels of drug-metabolizing enzymes and transporters in human jejunal tissues excised from morbidly obese subjects during gastric bypass surgery were evaluated using quantitative targeted absolute proteomics. 15 cytochrome P450 (CYP) enzymes, 10 UDP-glucuronosyltransferase (UGT) NADPH-P450 reductase (P450R) microsomal fractions 28 49 plasma membrane 24 the same determined liquid chromatography-tandem mass spectrometry. Based on average values, UGT1A1, UGT2B15, UGT2B17,...
Children with Prader-Willi syndrome (PWS) who receive GH treatment have improved growth and body composition; however, data are lacking for adults when is discontinued after completion of growth.Our aim was to compare composition metabolic status in PWS according childhood adolescence.64 (mean age: 25.4 years) a genetic diagnosis were evaluated: 20 received (T), which had been at the time this study, 44 did not (C). Mean duration T group 4.4 ± 2.7 years, age baseline 11.8 mean between end...
Obese patients have a high prevalence of painful musculoskeletal disorders that may decrease after massive weight loss. Pain thresholds be different in obese participants.To assess the sensitivity and pain detection thresholds, through application an electrical sensitivity, before loss, to compare obtained with those control population.The participants subjected stimulation were determined 31 individuals (age: 40.3 ± 10.5 y) (body mass index: 45.7 6.8 kg/m) 6 months mean loss 32 kg induced...
Cytochromes from the P450 family (CYP) play a central role in primary metabolism of frequently prescribed antidepressants, potentially affecting their efficacy and tolerance. There are however important differences drug metabolic capacities each individual resulting combination intrinsic environmental factors. This variability can present an risk for patients increases difficulty prescription clinical practice. Pharmacogenetic studies have uncovered number alleles defining metabolizer...
Abstract Rationale, aims and objectives The objective was to compare the extent of pain interference medication among persons who were classified as obese [body mass index ( BMI ) ≥30 kg m −2 ] normal weighted ≤25 ), before a hip or knee replacement surgery. Methods Patients candidate for an orthopaedic surgery successively enrolled, over 6‐month period, in either weight categories. Data collected using self‐administered questionnaires with items concerning characteristics, interference. Two...
The objective of our work was to study the association between jejunal expression levels P-gp, MRP2, MRP3, UGT2B7, CYP3A4, ABCB1 c.3435C > T polymorphism, and several obesity-associated biomarkers, as well oral morphine glucuronides pharmacokinetics in a population morbidly obese subjects. (30 mg) its performed patients candidate bariatric surgery. A fragment mucosa preserved during Subjects were genotyped for single nucleotide polymorphism (SNP) T. subjects 6 males 23 females, with mean...
Drug-metabolizing enzymes and drug transporters are key determinants of pharmacokinetics response. The cocktail-based cytochrome P450 (CYP) transporter phenotyping approach consists in the administration multiple CYP or transporter-specific probe drugs to determine their activities simultaneously. Several cocktails have been developed over past two decades order assess CYP450 activity human subjects. However, indices were mostly established for healthy volunteers. In this study, we first...