A5029957453- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Immune Cell Function and Interaction
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Oral and Maxillofacial Pathology
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Dental Implant Techniques and Outcomes
- Head and Neck Surgical Oncology
- Bone fractures and treatments
- Facial Nerve Paralysis Treatment and Research
- Skin Diseases and Diabetes
- Cancer and Skin Lesions
- Autoimmune Bullous Skin Diseases
- Trauma Management and Diagnosis
- Heat shock proteins research
- Facial Trauma and Fracture Management
- DNA Repair Mechanisms
- Effects of Radiation Exposure
Klinikum rechts der Isar
2017-2023
Technical University of Munich
2017-2023
München Klinik
2020
Tumor cells frequently overexpress heat shock protein 70 (Hsp70) and present it on their cell surface, where can be recognized by pre‐activated NK cells. In our retrospective study the expression of Hsp70 was determined in relation to tumor‐infiltrating CD56 + formalin‐fixed paraffin embedded (FFPE) tumor specimens patients with SCCHN ( N = 145) as potential indicators for survival disease recurrence. All received radical surgery postoperative cisplatin‐based radiochemotherapy (RCT)....
Mandibular reconstruction with the fibula free flap (FFF) is performed freehand, CAD/CAM-assisted, or by using partially adjustable resection/reconstruction aids. The two latter options represent contemporary reconstructive solutions of recent decade. purpose this study was to compare both auxiliary techniques regard feasibility, accuracy, and operative parameters.The first twenty consecutively operated patients requiring a mandibular (within angle-to-angle) FFF resection aids between...
Abstract Background Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor responses. In the present study, we aimed compare composition and kinetics of major lymphocyte subsets periphery patients with non-locoregional recurrent (n = 23) locoregional 9) squamous carcinoma head neck (SCCHN) upon primary RCT. Methods EDTA-blood SCCHN was collected before (t0), after application 20–30 Gy (t1), follow-up period 3 (t2) 6 months (t3)...
Microvascular reconstruction remains challenging in previously operated and irradiated patients, especially when double flaps seem to be the only solution due osteoradionecrosis. An alternative reconstructive option could microvascular anastomosis temporal vessels avoid obligatory cervical incision.All consecutive cases between January 2013 2020 that underwent either mandibular resection with a free fibula flap (FFF) another soft tissue (group I) or pure intraoral an FFF radial forearm (RFF)...
Oral squamous cell carcinomas (OSCCs) adjacent to the mandible or with clinically suspected bone infiltration are surgically treated either marginal segmental resections. This retrospective study compared both resections regarding local recurrence and lymph node secondary metastases.All consecutive primary OSCC cases between January 2007 December 2015 that underwent mandibular resection were included. Rates of recurrences metastases possible risk factors such as tumor localization according...
The behavior of blood flow changes within free flaps following microvascular anastomosis is not well described in the literature. aim this study was to determine immediate different as reference values for various clinical applications.Intraoperative transit-time measurements were performed on patients receiving flap transfer head and neck area comprising radial forearm (RFF), peroneal artery perforator (PAP), anterolateral thigh (ALT), vastus lateralis (VLF), parascapular (PSF), latissimus...
Abstract Purpose Oral squamous cell carcinomas (OSCC) adjacent to the mandible or with clinically suspected bone infiltration are surgically treated either marginal segmental resections. This retrospective study compared both resections regarding local recurrence and lymph node secondary metastases. Methods All consecutive primary OSCC cases between January 2007 December 2015 that underwent mandibular resection were included. Rates of recurrences metastases possible risk factors such as...
Abstract Background The aim of this study was to investigate the clinical course and redefine an optimized algorithm for OE cases until epithetic restoration. Methods Indication, defect type according Kesting, reconstructive technique, incidence postoperative complications peri‐implantitis, patients' quality life, timing periorbital implant insertion, interval loss, time restoration were analyzed in 43 patients. Results A significant correlation detected between wound dehiscence type. Out 24...
Abstract Background: Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor responses. In the present study, we aimed compare composition and kinetics of major lymphocyte subsets periphery patients with non-locoregional recurrent (n=23) locoregional (n=9) squamous carcinoma head neck (SCCHN) upon primary RCT. Methods: EDTA-blood SCCHN was collected before (t0), after application 20 30 Gy (t1), follow-up period 3 (t2) 6 months (t3)...