A5031574250- Chemical Synthesis and Reactions
- Organic Chemistry Cycloaddition Reactions
- Natural product bioactivities and synthesis
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Bioactive natural compounds
- Eicosanoids and Hypertension Pharmacology
- Estrogen and related hormone effects
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactive Compounds
- Bioactive Compounds and Antitumor Agents
- Neuroscience and Neuropharmacology Research
- Bioactive Natural Diterpenoids Research
- Receptor Mechanisms and Signaling
- Protein Degradation and Inhibitors
- Sesquiterpenes and Asteraceae Studies
- Fluorine in Organic Chemistry
- Peptidase Inhibition and Analysis
- Insect Pest Control Strategies
- Adenosine and Purinergic Signaling
- Chemical Synthesis and Analysis
- Steroid Chemistry and Biochemistry
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
University of Coimbra
2005-2025
Universidade Nova de Lisboa
1995-2002
Instituto de Biologia Experimental e Tecnológica
1997
University of Lisbon
1995
Abstract Mint species are widely used in traditional and conventional medicine as topical analgesics for osteoarthritic pain disorders of the gastrointestinal respiratory tracts which all associated with chronic inflammation. To identify structural determinants anti-inflammatory activity potency required chemical optimization towards development new drugs, a selected group monoterpenes especially abundant mint was screened by measuring bacterial lipopolysacharide (LPS)-induced nitric oxide...
To explore the molecular mechanisms underlying anti-inflammatory activity of (R)-(-)-carvone, we evaluated its ability to inhibit signaling pathways involving mitogen-activated protein kinases (MAPKs) and transcription factor, nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB). (R)-(-)-carvone significantly decreased c-Jun N-terminal kinase (JNK) 1phosphorylation, but not that other MAPKs, induced by bacterial lipopolysaccharides (LPS) in RAW 264.7 macrophage cell line....
The Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A) held its 32nd annual conference August 2024 at University Coimbra, Portugal. There were 8 keynote presentations, 12 early career researcher oral and 34 poster presentations. Four awards delivered, two best communications
The chemical modification of natural compounds is a promising strategy to improve their frequently poor bioavailability and low potency. This study aimed at synthesizing derivatives carvone, monoterpene with anti-inflammatory properties, which we recently identified, evaluating potential activity. Fourteen carvone were synthesized, purified structures confirmed. Noncytotoxic concentrations the test selected based on resazurin reduction assay. Among tested compounds, four significantly...
The signaling pathways involved in age-related inflammation are increasingly recognized as targets for the development of preventive and therapeutic strategies. Our previous study elucidated structure–activity relationship monoterpene compounds derived from p-menthane potential anti-inflammatory drugs identified (S)-(+)-carvone most potent among tested. This aims at identifying molecular mechanism underlying properties (S)-(+)-carvone. murine macrophage cell line, Raw 264.7, was stimulated...
Cell lines used to study the role of G protein-coupled receptor 30 (GPR30) or estrogen (GPER) as a mediator responses have yielded conflicting results. This work identified simple assay predict cell line competence for pharmacological studies GPR30.The phosphorylation expression levels ERK1/2, Akt, c-Fos and eNOS were evaluated assess GPR30 activation in response known agonists (17β-estradiol G-1) MCF-7 T-47D breast cancer bovine aortic endothelial cells. was analyzed by qRT-PCR Western blot...
The selective formation of optically active 2-acyl-2-alkyl-1,3-dithiolane 1,1-dioxides from the corresponding 1-oxides, by reaction with OsO4 and NMO in acetone, is reported. These compounds underwent stereoselective reactions at carbonyl group acyl organometallic reagents. were completely regioselective, no attack either S-atoms was observed, unlike similar sulfoxides. nature metal atom had a direct effect upon configuration product alcohols.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract For see ChemInform in Full Text.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”