A5067185629- Research on Leishmaniasis Studies
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Trypanosoma species research and implications
- Viral Infections and Outbreaks Research
- Travel-related health issues
- Parasites and Host Interactions
- COVID-19 epidemiological studies
- Synthesis and Biological Evaluation
- Respiratory viral infections research
- Leptospirosis research and findings
- COVID-19 and Mental Health
- Global Health and Surgery
- Synthesis and biological activity
- Zoonotic diseases and public health
- Insect and Pesticide Research
- Global Health Care Issues
- Health Systems, Economic Evaluations, Quality of Life
- Bird parasitology and diseases
- Climate Change and Health Impacts
Institut Pasteur de Tunis
2010-2024
Université du Québec à Trois-Rivières
2023
Institut Pasteur
2021
Tunis University
2018
Tunis El Manar University
2018
There is a need for simple and efficacious treatment cutaneous leishmaniasis with an acceptable side-effect profile.We conducted randomized, vehicle-controlled phase 3 trial of topical treatments containing 15% paromomycin, without 0.5% gentamicin, caused by Leishmania major in Tunisia. We randomly assigned 375 patients one to five ulcerative lesions from receive cream paromomycin-0.5% gentamicin (called WR 279,396), paromomycin alone, or vehicle control (with the same base as other two...
Background Old world Zoonotic Cutaneous Leishmaniasis (ZCL) is a vector-borne human disease caused by Leishmania major, unicellular eukaryotic parasite transmitted pool blood-feeding sand flies mainly to wild rodents, such as Psammomys obesus. The beings who share the rodent and fly habitats can be subverted both blood resource. ZCL endemic in Middle East, Central Asia, Subsaharan North Africa. Like other diseases, incidence of displayed humans varies with environmental climate factors....
A study was undertaken between November 2008 and March 2010, in the focus of cutaneous leishmaniasis Central Tunisia, to evaluate role Psammomys obesus (n=472) Meriones shawi (n=167) as reservoir hosts for Leishmania major infection. Prevalence L. infection 7% versus 5% culture (p=not signifiant [NS]), 19% 16% direct examination smears (p=NS), 20% 33% (p=NS) Indirect Fluorescent Antibody Test among P. M. shawi, respectively. The peak this winter autumn increased steadily with age both...
Zoonotic Cutaneous Leishmaniasis (ZCL) due to Leishmania major (L. major) is still a serious public health problem in Tunisia. This study aimed compare the prevalence and risk factors associated with L. infection old new foci using leishmanin skin test (LST) central Tunisia.A cross sectional household survey was carried out between January May 2009 on sample of 2686 healthy individuals aged 5 65 years. We determined LST. Risk LST positivity were assessed logistic regression model.The overall...
Although non-fatal and mostly self-healing in the case of Leishmania (L.) major, cutaneous leishmaniasis (CL) is mainly treated to reduce lesion healing time. Less attention paid improvement scars, especially aesthetically relevant areas body, which can dramatically affect patients' wellbeing. We explored perspectives about treatment options social psychological burden disease (lesion scar). Individual in-depth interviews were conducted with ten confirmed CL patients at two L. major endemic...
Abstract Background Generally, seasonal influenza does not cause severe infection in healthy adults, but for the elderly, an can pose a serious health concern. Although several measures help prevent influenza, vaccination is considered most effective. This study aimed to assess vaccine uptake among elderly with chronic diseases Tunisia during 2018–2019 season, and identify knowledge, attitudes barriers associated uptake. Methods During season of 2018–2019, we conducted national...
Cutaneous leishmaniasis (CL) is a disease that often affects exposed skin areas and may heal leaving lifelong scars. Patients' expectations from treatment are rarely considered in drug development for CL. An initiative aiming to address shortcomings clinical trial design conduct CL treatments involving the researchers' community on-going. This manuscript presents patient-preferred outcomes an assessment on how consider these of future trials.We report preferred by 74 patients with confirmed...
The influenza vaccine (IV) is considered the most effective strategy to prevent seasonal infection and annual vaccination of healthcare workers (HCWs) recommended by World Health Organization given their high mixing with patients. We assessed IV uptake among HCWs in 2018-2019 season explored knowledge attitudes regarding immunization.
Zoonotic cutaneous leishmaniasis, caused by Leishmania major (L. major), is endemic in Tunisia. Several rodents have been identified as reservoir hosts of parasites. This study reports, for the first time, natural infection with L. zymodeme MON-25 a specimen least weasel: Mustela nivalis Linnaeus, 1776 (M. nivalis) collected Sidi Bouzid. finding justifies further research on larger samples this animal to verify its role potential host leishmaniasis
Lack of investments in drug development, lack standardisation clinical trials and the complexity disease presentations contribute to current effective, safe adapted treatments for cutaneous leishmaniasis (CL). One aspect concerns outcomes affecting patients' quality life (QoL): these are hardly assessed trials, despite potential functional and/or aesthetic impairment caused by CL, which typically affects disadvantaged vulnerable people living rural areas. Here, we describe approach used...
Les problèmes complexes de la santé publique nécessitent des stratégies recherche intégratrices qui transcendent le cadre inter et multidisciplinaire. Ces s’appuient sur l’approche transdisciplinaire parce que celle-ci permet, d’une part, dialogue entre les sciences humaines et, d’autre comprendre phénomènes tout en engageant parties prenantes dans voies solutions. Le but ultime est une co-construction savoirs, à partir savoirs académiques populaires, associant différentes disciplines...
Background Pregnant women (PW) and older adult with chronic diseases (ECD) are priority groups for the influenza vaccination. This study was designed to have a better insight into perceptions barriers of vaccine uptake from these groups’ perspectives. Methods qualitative consisted 20 focus group discussions (FGDs) enrolled five governorates across country (north, center, south) between March 18 July 10, 2019, in urban rural areas. FGDs were conducted Arabic (Tunisian dialect) following topic...
Background: The influenza vaccine (IV) is considered the most effective strategy to prevent seasonal infection and annual vaccination of healthcare workers (HCWs) recommended by World Health Organization given their high mixing with patients. We assessed IV uptake among HCWs in 2018–2019 season explored knowledge attitudes regarding immunization. Methods: A cross-sectional study was conducted 150 representative Tunisian health facilities from March May 2019. recruited 1,231 direct patient...
In Tunisia, 17 phlebotomine sand fly species are reported, belonging to genera Phlebotomus and Sergentomyia. However, subsequent faunal studies outbreaks of leishmaniasis in different regions the country, unrecognized could exist. Indeed, we report this study presence Sergentomyia (Parrotomyia) lewisiParrot 1948. A brief collection flies was undertaken August 2016 Khbina locality, Sidi Bouzid governorate situated Central which constitutes an old focus Zoonotic Cutaneous Leishmaniasis. Sand...
Abstract Background Most countries of the Eastern Mediterranean Region have low influenza vaccination coverage mainly among high risk groups. Advice to receive vaccine by healthcare workers (hcws) seems be an important motivator for acceptance patients. In this study, we aimed describe willingness Tunisian hcws recommend seasonal patients and assess its determinants. Methods A cross-sectional questionnaire-based study was conducted in primary secondary facilities during 2018-2019 season....
Abstract Background Given the nature of their activities, health care workers (hcws) are at higher risk contracting influenza and transmitting disease to patients. Influenza vaccine (IV) remains most effective way prevent its complications. To best our knowledge, no national data on IV coverage among hcws is available in Tunisia. The present study aimed assess flu vaccination Tunisian 2018-2019 season factors associated with uptake through a knowledge attitudes related vaccination. Methods A...
Abstract Background Influenza vaccination coverage among elderly remains unsatisfactory even in developed countries. Since attitudes are predictors of behavior, understanding factors influencing the intention to receive influenza vaccine (IV) may orientate interventions increase rate. The aim current study was identify associated willingness IV next season Tunisian elderly. Methods During 2018 -2019 flu a cross-sectional conducted older persons aged 60 years and over with chronic disease...
Abstract Background Surveys to determine the uptake of influenza vaccine (IV) among at-risk groups are required evaluate advancement national vaccination strategies and level awareness in surveyed population. In this context, present study aimed estimate elderly Tunisia during 2018-2019 season assess their perceptions toward IV. Methods It was a cross-sectional conducted 2019 primary secondary health care facilities, persons aged 60 years over with chronic disease. Data were collected using...
Abstract Background: The influenza vaccine (IV) is considered the most effective strategy to prevent seasonal infection and annual vaccination of healthcare workers (HCWs) recommended by World Health Organization given their high mixing with patients. We assessed IV uptake among HCWs in 2018-2019 season explored knowledge attitudes regarding immunization. Methods: A cross-sectional study was conducted 150 representative Tunisian health facilities from March May 2019. recruited 1,231 direct...
Abstract Background Influenza is a contagious respiratory disease that may lead to severe illness. Given their frequent contact with ill individuals, healthcare workers (HCWs) are at elevated risk of developing influenza and transmitting the patients. We aimed in this study assess flu vaccination intention among Tunisian HCWs identify its determinants. Methods A cross sectional was conducted direct patient during 2018-2019 season. Participants were recruited primary secondary facilities...