Shigeo Sato

ORCID: 0000-0003-3912-357X
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About
Contact & Profiles
Research Areas
  • Neural Networks and Applications
  • Advanced Memory and Neural Computing
  • Neural dynamics and brain function
  • Neural Networks and Reservoir Computing
  • Semiconductor materials and devices
  • Quantum Computing Algorithms and Architecture
  • Neuroscience and Neural Engineering
  • Quantum Information and Cryptography
  • Quantum and electron transport phenomena
  • Cancer Mechanisms and Therapy
  • Advancements in Semiconductor Devices and Circuit Design
  • Synthesis and biological activity
  • Cancer therapeutics and mechanisms
  • stochastic dynamics and bifurcation
  • Electron and X-Ray Spectroscopy Techniques
  • Thin-Film Transistor Technologies
  • X-ray Spectroscopy and Fluorescence Analysis
  • Physics of Superconductivity and Magnetism
  • Fusion materials and technologies
  • Metal and Thin Film Mechanics
  • Nuclear Physics and Applications
  • Semiconductor Quantum Structures and Devices
  • Silicon and Solar Cell Technologies
  • Low-power high-performance VLSI design
  • Nuclear reactor physics and engineering

Tohoku University
2016-2025

Ibaraki University
2014-2024

Hitachi (Japan)
2014-2024

Hirosaki University
2024

Japanese Foundation For Cancer Research
1996-2023

Spintronics Research Network of Japan
2005-2021

National Institutes for Quantum Science and Technology
2021

Ono Pharmaceutical (Japan)
2019

Physical Devices (United States)
1995-2017

Sendai University
2016

Abstract We demonstrate associative memory operations reminiscent of the brain using nonvolatile spintronics devices. Antiferromagnet–ferromagnet bilayer-based Hall devices, which show analogue-like spin–orbit torque switching under zero magnetic fields and behave as artificial synapses, are used. An neural network is used to associate memorized patterns from their noisy versions. develop a consisting field-programmable gate array 36 effect learning on successfully confirmed for several 3 ×...

10.7567/apex.10.013007 article EN Applied Physics Express 2016-12-20

Background: Glucose deprivation, a feature of poorly vascularized solid tumors, activates the unfolded protein response (UPR), stress-signaling pathway, in tumor cells. We recently isolated novel macrocyclic compound, versipelostatin (VST), that inhibits transcription from promoter GRP78, gene is activated as part UPR. examined effect VST on UPR induced by glucose deprivation or other stressors and growth vivo. Methods: Human colon cancer HT-29, fibrosarcoma HT1080, stomach MKN74 cells were...

10.1093/jnci/djh243 article EN JNCI Journal of the National Cancer Institute 2004-08-31

Endoscopic sphincterotomy is a widely accepted technique for the treatment of patients with common bile duct stones. However, it still associated occasional complications. The recently developed endoscopic papillary balloon dilation seems to be safe and effective procedure, have great potential replacing sphincterotomy. few reports been published on use this present study was undertaken evaluate its safety efficacy.Endoscopic used remove stones in 226 consecutive including 41 ASA...

10.1055/s-2007-993721 article EN Endoscopy 1998-01-01

There is a wide recognition that Josephson-junction-like structures intrinsic to the layered cuprate high temperature superconductors offer an attractive stage for exploiting possible applications new quantum technologies. On other hand low energy quasiparticle excitations characteristically present in these d-wave may easily destruct coherence required. Here we demonstrate first time feasibility of macroscopic tunneling Josephson junctions superconductor, and find it be characterized by...

10.1103/physrevlett.95.107005 article EN Physical Review Letters 2005-09-02

Thulium imparts BaZrO<sub>3</sub> with the highest proton conductivity. A good correlation exists between conductivity and chemical expansion effect as a result of incorporation protons.

10.1039/c4ta05701e article EN Journal of Materials Chemistry A 2014-11-19

Balance of functional integrability and spatial segregation mediates dynamical richness in modular cortical networks.

10.1126/sciadv.aau4914 article EN cc-by-nc Science Advances 2018-11-02

Reservoir computing is a machine learning paradigm that transforms the transient dynamics of high-dimensional nonlinear systems for processing time-series data. Although was initially proposed to model information in mammalian cortex, it remains unclear how nonrandom network architecture, such as modular cortex integrates with biophysics living neurons characterize function biological neuronal networks (BNNs). Here, we used optogenetics and calcium imaging record multicellular responses...

10.1073/pnas.2217008120 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2023-06-12

High-level information processing in the mammalian cortex requires both segregated specialized circuits and integration across multiple circuits. One possible way to implement these seemingly opposing demands is by flexibly switching between states with different levels of synchrony. However, mechanisms behind control complex synchronization patterns neuronal networks remain elusive. Here, we use precision neuroengineering manipulate stimulate cortical neurons vitro, combination an silico...

10.1126/sciadv.ade1755 article EN cc-by-nc Science Advances 2023-08-25

This paper presents results of conceptual design activities and associated R&D a solid breeder blanket system for demonstration power generation fusion reactors (DEMO blanket) cooled by supercritical water. The Fusion Council Japan developed the long-term research development programme in 1999. To make DEMO reactor more attractive, higher thermal efficiency than 40% was strongly recommended. meet this requirement, carried out. In conjunction with design, new concept water proposed technology...

10.1088/0029-5515/43/12/026 article EN Nuclear Fusion 2003-12-01

Single-walled carbon nanohorns (SWNHs) are single-graphene tubules that have shown high potential for drug delivery systems. In delivery, it is essential to quantitatively determine biodistribution and ultrastructural localization. However, date, these determinations not been successfully achieved. this report, we describe the first time a method can achieve determinations. We embedded Gd(2)O(3) nanoparticles within SWNH aggregates (Gd(2)O(3)@SWNHag) facilitate detection quantification....

10.1021/nn9004846 article EN ACS Nano 2009-05-29

The concept for a compact DEMO reactor named 'SlimCS' is presented. Distinctive features of the are low aspect ratio (A = 2.6) and use reduced-size centre solenoid (CS) which has function plasma shaping rather than poloidal flux supply. CS enables us to introduce thin toroidal field coil system contributes reducing weight perhaps lessening construction cost. Low-A merits vertical stability high elongation (κ) normalized beta (βN), leads power density with reasonable physics requirements....

10.1088/0029-5515/47/8/022 article EN Nuclear Fusion 2007-07-24

Assured dispersibility is a prerequisite for clinical application of nanomaterials. Carbon nanomaterials have hydrophobic surfaces and thus readily agglomerate under aqueous conditions. Various conjugates composed carbon surface-binding moiety polyethylene glycol (PEG) been examined as dispersants Here we synthesized conjugate comb-shaped PEG (cPEG) nanomaterial-binding peptide (NHBP-1). The resultant cPEG-NHBP3 displayed multiple units (2.4 on average) NHBP-1 single cPEG molecule whose...

10.1021/mp800141v article EN Molecular Pharmaceutics 2009-01-27

Pendellösung intensity beats of white radiation diffracted from parallel-sided single-crystal wafers silicon were measured by a solid-state detector. After few corrections, the extremum positions in beat to evaluate atomic scattering factors for various reflections. The factor shows dependence on wavelength, λ, which can be interpreted anomalous dispersion term, f', as calculated Cromer [Acta Cryst. (1965), 18, 17-23]. obtained values expressed linear functions wavelength are listed with...

10.1107/s0567739480002070 article EN Acta Crystallographica Section A 1980-11-01

We study the effect of network size on synchronized activity in living neuronal networks. Dissociated cortical neurons form synaptic connections culture and generate spontaneous within 10 days vitro. Using micropatterned surfaces to extrinsically control networks, we show that can emerge a as small 12 cells. Furthermore, detailed comparison (∼20 cells), medium (∼100 large (∼400 cells) networks reveal becomes destabilized A computational modeling neural is then employed explore underlying...

10.1103/physreve.94.012407 article EN publisher-specific-oa Physical review. E 2016-07-13

The widely used solvent for perovskite materials, dimethylformamide (DMF), is readily adsorbed on the TiO<sub>2</sub> surface and hinders charge transfer at interface.

10.1039/c5ta08098c article EN Journal of Materials Chemistry A 2016-01-01

Neuronal networks in dissociated culture combined with cell engineering technology offer a pivotal platform to constructively explore the relationship between structure and function living neuronal networks. Here, we fabricated defined possessing modular architecture on high-density microelectrode arrays (HD-MEAs), state-of-the-art electrophysiological tool for recording neural activity high spatial temporal resolutions. We first established surface coating protocol using cell-permissive...

10.3389/fnins.2022.943310 article EN cc-by Frontiers in Neuroscience 2023-01-09

Even though many neurochips have been developed and investigated, the best suitable way for implementation has not known clearly. Our approach is to exploit stochastic logic various operations required neural functions. The advantage of that complex can be implemented with a few ordinary gates. On other hand, operation speed so fast since requires certain accumulation time averaging. However, huge integration achieved its reliability high because all are done on digital circuits....

10.1109/tnn.2003.816341 article EN IEEE Transactions on Neural Networks 2003-09-01
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