A5003865674- HIV/AIDS Research and Interventions
- HIV/AIDS Impact and Responses
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Food Safety and Hygiene
- HIV Research and Treatment
- Pharmacogenetics and Drug Metabolism
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Bacillus and Francisella bacterial research
- Diagnosis and treatment of tuberculosis
- HIV-related health complications and treatments
- Toxin Mechanisms and Immunotoxins
- Bacteriophages and microbial interactions
- Steroid Chemistry and Biochemistry
- Influenza Virus Research Studies
- Chronic Myeloid Leukemia Treatments
- Microbial Natural Products and Biosynthesis
- Biological Stains and Phytochemicals
- HIV, Drug Use, Sexual Risk
- Global Maternal and Child Health
- Milk Quality and Mastitis in Dairy Cows
- Signaling Pathways in Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
Central University of Technology
2012-2023
Abstract Since the initial identification of cytochrome P450 monooxygenases (CYPs/P450s), great progress has been made in understanding their structure-function relationship, diversity and application producing compounds beneficial to humans. However, molecular evolution P450s terms dynamics both at protein DNA levels functional conservation across kingdoms still needs investigation. In this study, we analyzed 17 598 belonging 113 families (bacteria −42; fungi −19; plant −28; animal −22; −1...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Mugomeri E, Olivier D, van den Heever W. Health system challenges affecting the implementation of isoniazid preventive therapy in people living with HIV Lesotho. & AIDS Review. International Journal HIV-Related Problems. 2018;17(4):299-307. doi:10.5114/hivar.2018.80263. APA Mugomeri, E., Olivier, D., Heever, (2018). Problems, 17(4), 299-307. https://doi.org/10.5114/hivar.2018.80263 Chicago Eltony, Dedré and...
Background: The South African Expanded Programme on Immunisation (EPI-SA) currently vaccinates against 10 childhood vaccine preventable diseases. Six injections are required for primary vaccination diphtheria, tetanus, pertussis, polio, Haemophilus influenza type b and hepatitis B: three DTaP-IPV//Hib [Pentaxim®] doses monovalent Hep B vaccines to children under 12 months of age, with a seventh injection (Pentaxim® booster) at 18 months. Madhi et al (PIDJ 30:e68 2011) demonstrated no...
The presence of pathogenic bacteria in milk is a possible source food-borne diseases. One hundred and sixty non-pasteurised forty pasteurised samples from the Maseru area were analysed for bacteria. It recommended by legislation that be free bacteria, microbial counts must within ranges as stipulated Regulation 1555 21 November 1997. Eighty seven had high total aerobic bacterial not range outlined 1555, whereas twenty unacceptably counts. Unacceptably E. coli detected thirty five samples....
Lesotho introduced tenofovir disoproxil fumarate (TDF) for first-line antiretroviral treatment (ART) in 2008. The use of TDF has been associated with renal toxicity. study utilised an analytical design to compare retrospective creatinine clearance (CrCl) data 312 naive adults exposed and 173 unexposed patients. Impaired function was defined as CrCl 60 (p=0.004) were significantly CrCl<50 ml/min outcome. is a weak contributing factor impairment. Routine baseline screening should be adopted...
The government of Lesotho introduced tenofovir disoproxil fumarate (TDF) for first-line antiretroviral treatment (ART), as recommended by the World Health Organization (1), in 2008. use TDF has been associated with renal toxicity (2); furthermore, function outcomes following not studied at Roma Service Area (RHSA) Lesotho. is a small landlocked country surrounded South Africa. study used an analytical design to compare retrospective creatinine clearance (CrCl) data 312 (64%) naïve adults...
Background HIV recency assays are used to distinguish recently acquired infection from long-term among individuals newly diagnosed with HIV. Since 2015, the World Health Organisation recommends use of an algorithm assess infections which is based on assay and viral load (VL) quantification. We determined proportion recent participants VIBRA (Village-Based Refill Antiretroviral therapy) cluster-randomized trial in Lesotho assessed risk factors for these infections. Methods The recruited...
Tuberculosis (TB) remains a public health problem, particularly in people living with human immunodeficiency virus (PLHIV). Yet, efforts to reduce TB incidence using isoniazid preventive therapy (IPT) have been curtailed by poor uptake of this intervention. This study reviewed the rate IPT initiation sub-Saharan country Lesotho, which has one highest incidences world.Time randomly sampled medical records PLHIV was analysed Cox's proportional hazards regression. Differences periods enrolment...
Background: The current review article outlines findings in literature from undertaken studies and articles on the plant Elephantorrhiza elephantine past 20 years to date. information presented this will include following aspects of plant. description taxomony, ethnomedical uses, phytochemistry pharmacology elephantine. looks discuss existing hurdles research found how integrate any previous with what is currently done It aims guiding path future direction Methods: A total 40 were selected...
Lesotho faces a catastrophic syndemic of HIV and tuberculosis (TB). In 2011, the government launched isoniazid preventive therapy (IPT) as once-off intervention to reduce occurrence TB in HIV-positive people. This study evaluated effectiveness IPT durability its based on Cox’s proportional hazards regression analysis 2 955 records randomly sampled from six districts Lesotho. The overall incidence rate was 2.0 per 100 person-years 12 208 person-years. Thirty-nine (15.9%, n=246) patients...