A5032572523- Antibiotics Pharmacokinetics and Efficacy
- Statistical Methods in Clinical Trials
- Veterinary Medicine and Surgery
- Cardiovascular Conditions and Treatments
- Clinical Laboratory Practices and Quality Control
- Veterinary Equine Medical Research
- Cardiovascular Function and Risk Factors
- Genetic and phenotypic traits in livestock
- Pharmacogenetics and Drug Metabolism
- Statistical Methods and Inference
- Antibiotic Resistance in Bacteria
- Chronic Kidney Disease and Diabetes
- Pharmaceutical studies and practices
- Statistical Methods and Bayesian Inference
- Meta-analysis and systematic reviews
- Veterinary Pharmacology and Anesthesia
- Pharmaceutical Economics and Policy
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Muscle metabolism and nutrition
- Congenital Heart Disease Studies
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Microbial infections and disease research
- Renal function and acid-base balance
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2012-2025
École Nationale Vétérinaire de Toulouse
2016-2025
Innovations thérapeutiques et résistances
2018-2024
CNR de la Résistance aux Antibiotiques
2018-2024
Université de Toulouse
2015-2024
Université Toulouse III - Paul Sabatier
1997-2022
Institut National Polytechnique de Toulouse
2000-2019
Toxalim Research Centre in Food Toxicology
2011-2018
École Normale Supérieure - PSL
1999-2012
Institut Claudius Regaud
2010-2012
International recommendations for determination of reference intervals have been recently updated, especially small sample groups, and use the robust method Box-Cox transformation is now recommended. Unfortunately, these methods are not included in most software programs used data analysis by clinical laboratories. We created a set macroinstructions, named Reference Value Advisor, Microsoft Excel to calculate limits applying different methods. For any series data, Advisor calculates (with...
The objective of this study was to determine the intra‐ and inter‐observer variability echocardiographic measurements in dogs. Four observers with different levels experience echocardiography performed 192 examinations six dogs on four days. lowest within‐ between‐day coefficients variation (CV) (%) were 13.8 5.2 for right ventricle diastole, 8.9 4.5 interventricular septal thickness diastole (6.3 7.0 systole), 7.7 9.4 left ventricular free‐wall (8.1 3.1 5.0 end‐diastolic diameter (6.2...
Abstract Objective —To determine left ventricular free wall (LVFW) radial and longitudinal myocardial contraction velocities in healthy dogs via quantitative 2-dimensional color tissue Doppler imaging (TDI). Animals —100 dogs. Procedure —TDI was used by a single trained observer to measure movement the LVFW. Radial were recorded segments endocardial epicardial layers of LVFW, at 3 levels (basal, middle, apical) Results —LVFW higher than layers. Left basal middle apical segments. velocity...
Plasma clearance of creatinine was evaluated for assessment glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24-hour urine endogenous creatinine, plasma, and clearances exogenous administered at 40, 80, 160 mg/kg a crossover design (linearity study), plasma iothalamate clearance, 14C-inulin. Experiment 2, were compared, linearity study performed as 1 with surgically induced renal impairment. 3 compared before weeks after induction moderate impairment...
Summary The objective of this study was to determine intra‐ and inter‐observer variability echocardiographic measurements in awake cats. Four observers with different levels experience echocardiography performed 96 examinations four cats on days over a 3‐week period. were randomized blinded. maximum within‐day between‐day CV values 17.4 18.5% for inter‐ventricular septal thickness diastole, 18.7 22.6% left ventricular free‐wall 9.8 14.9% end‐diastolic diameter, 20.8 15.2% end‐systolic 21.2...
Plasma clearance of creatinine was evaluated for assessment glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine endogenous creatinine, plasma, and clearances exogenous administered at 40, 80, 160 mg/kg a crossover design (linearity study), plasma iothalamate clearance, 14 C‐inulin. Experiment 2, were compared, linearity study performed as 1 with surgically induced renal impairment. 3 compared before weeks after induction moderate impairment...
In France, more than 2.5 million patients are currently treated with levothyroxine, mainly as the marketed product Levothyrox®. March 2017, at request of French authorities, a new formulation Levothyrox® was licensed, objective avoiding stability deficiencies old formulation. Before launching this formulation, an average bioequivalence trial, based on European Union recommended guidelines, performed. The implicit rationale assumption that two products, being bioequivalent, would also be...
Abstract Objective —To measure the radial and longitudinal velocities of several myocardial segments left ventricular wall by use tissue Doppler imaging (TDI) in healthy cats determine repeatability reproducibility technique. Animals —6 cats. Procedure —72 TDI examinations were performed on 4 days same trained observer. Radial parameters included endocardial epicardial velocities. Longitudinal basal, middle, apical Results —All velocity profiles had 1 positive systolic wave (S) 2 negative...
Abstract Objective —To determine left ventricular free wall (LVFW) motions and assess their intra- interday variability via tissue Doppler imaging (TDI) in healthy awake anesthetized dogs. Animals —6 adult Beagles. Procedure —In the first part of study, 72 TDI examinations (36 radial 36 longitudinal) were performed by same observer on 4 days during a 2-week period all In second part, 3 dogs with isoflurane vecuronium. Two measurements each parameter made 2 consecutive cardiac cycles when...
According to international recommendations, reference intervals should be determined from at least 120 individuals, which often are impossible achieve in veterinary clinical pathology, especially for wild animals. When only a small number of subjects is available, the possible bias cannot known and normality distribution evaluated. A comparison estimated by different methods could helpful.The purpose this study was compare limits large set canine plasma creatinine values, subsets data, with...
Purpose Area under the curve (AUC) dosing is routinely carried out for carboplatin, but chosen target AUC values remain largely empirical. This multicenter pharmacokinetic-pharmacodynamic (PK-PD) study was performed to determine covariates involved in interindividual variability of carboplatin hematotoxicity that should be considered when choosing individual AUCs. Patients and Methods Three hundred eighty-three patients received as part established regimens. A semi-physiologic population...
The laser-based Sysmex XT-2000iV hematology analyzer is increasingly used in veterinary clinical pathology laboratories, and instrument-specific reference intervals for dogs are not available.The purpose of this study was to establish canine hematologic according International Federation Clinical Chemistry Laboratory Standards Institute guidelines using the analyzer.Blood samples from 132 healthy purebred France, selected represent most prevalent breeds were analyzed. Blood smears scored...
Background Increasing salt intake to promote diuresis has been suggested in the management of feline lower urinary tract disease. However, high dietary might adversely affect blood pressure and renal function. Objectives The objective this study was assess long‐term effects increased on function healthy aged cats. Methods This controlled, randomized, blinded. Twenty neutered cats (10.1 ± 2.4 years) were randomly allocated into 2 matched groups. One group fed a diet (3.1 g/Mcal sodium, 5.5...
Right ventricular myocardial (RVM) motion is poorly documented. The objective of this study was to determine the variability RVM velocities by tissue Doppler imaging (TDI) in healthy dogs (study 1), analyze a large canine population 2), and compare results with those obtained for left free wall. Six Beagle Dogs were monitored 1, 64 14 different breeds 2. Velocities recorded 2 segments (basal apical) right walls. In 36 TDI examinations performed 4 days, whereas single examination on each dog...
To evaluate the effects of positioning and number repeated measurements on intra- interobserver variability echocardiographic in dogs.Prospective study.4 healthy dogs.Each observer performed 24 examinations, separately assessing each dog 6 nonconsecutive times (3 with lateral recumbency 3 a standing position). Variables evaluated included M-mode left ventricular end-diastolic end-systolic diameters, free-wall thickness diastole systole, interventricular septal shortening fraction,...