A5074321738- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Fetal and Pediatric Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Epigenetics and DNA Methylation
- Cervical and Thoracic Myelopathy
- Histone Deacetylase Inhibitors Research
- Craniofacial Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Pelvic and Acetabular Injuries
- Radiopharmaceutical Chemistry and Applications
- Cerebral Venous Sinus Thrombosis
- Olfactory and Sensory Function Studies
- Cancer-related molecular mechanisms research
- Ophthalmology and Eye Disorders
- Neuroblastoma Research and Treatments
- Epilepsy research and treatment
- Hedgehog Signaling Pathway Studies
- Anesthesia and Neurotoxicity Research
- Protein Degradation and Inhibitors
- Ocular Oncology and Treatments
- Immune Cell Function and Interaction
- Forensic Anthropology and Bioarchaeology Studies
- Autopsy Techniques and Outcomes
Children's Memorial Health Institute
2014-2024
Medical University of Warsaw
2004-2024
Academic Center of Medicine
2006
Diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain tumors, non-resectable due to brainstem localization and diffusive growth. Over 80% of DIPGs harbor a mutation in histone 3 (H3.3 or H3.1) resulting lysine-to-methionine substitution (H3K27M). Patients with DIPG have dismal prognosis no effective therapy. We show that deacetylase (HDAC) inhibitors lead significant reduction the H3.3K27M protein (up 80%) multiple glioma cell lines. discover SB939-mediated loss is partially...
The authors report a case of germinoma the brain in child with symptoms restricted to central nervous system. Ten-year-old girl presented initially sight deterioration, learning difficulties, abnormal behavior, polydipsia, and polyuria. Brain magnetic resonance examination revealed T2 hyperintensity corpus callosum, anterior commissure, caudate nuclei. biopsy extensive macrophage infiltration. Given these results positive antinuclear antibodies blood, immunosuppressive immunomodulatory...
To assess whether the middle temporal gyrus (MTG) approach to mesial lobe (MTL) tumours is an effective procedure for treatment of epilepsy in children.
A case of atlas assimilation revealed during serial study suboccipital region is presented. The specimen was harvested from the body 31-year-old woman. Images computed tomography scans are correlated with classic dissection. Asymmetrical bony accompanied by asymmetrical development musculature. In presented case, atlantic segments both vertebral arteries preserved their usual course between elements derived and proatlas. Development soft tissues must be influenced similar factors as...
Examination of copy number changes in a group intracranial germ cell tumors (GCTs) with particular focus on putative aberrations the main genes coding SHh pathway proteins.The study was performed DNA isolated from fresh-frozen tumor tissue samples eight GCTs, including six GCTs. The consisted three germinomas, two mature teratomas and one mixed tumor. Comparative genomic profiling analysis carried out using microarray-CGH method (Cytosure ISCA UPD 4×180k, OGT). results were analyzed Feature...
To present case of vertebral artery duplication surrounding the posterior arch atlas.The variation was encountered during dissection specimen from body a 62-year-old man.The formed circle located extraduraly, atlas vertebra. Topography and morphometry finding is described. Embryology clinical significance based on literature review are discussed.Precise diagnostic imaging necessary before surgical interventions at level cranio-spinal junction in order to avoid conflict with rare vascular variations.
The atlantic segment of vertebral artery (V3) located at the centre cranio-vertebral junction is known for its variability and asymmetry, either target or on way numerous procedures in this region. aim study was to visualise V3 segment.The studied 49 specimens suboccipital region injected with coloured gelatine. Direct measurements were performed probabilistic maps created using digital photography.The has wavy course possible lateral significant postero-inferior expansions. In relation...
Abstract INTRODUCTION Infants constitute approximately 5% of all pediatric LGG. This group is identified as having aggressive course and worse prognosis compared to older children. No specific therapeutic guidelines are yet available for this age group. AIM: Retrospective analysis infants diagnosed treated METHODOLOGY: 25 patients between 2001-2023 were analyzed for: sex, age, tumor location, pathology, treatment outcome. NF1 excluded. RESULTS There 13 boys 12 girls, aged 3 months-11 months,...
ABSTRACT Diffuse intrinsic pontine gliomas (DIPG) are deadly paediatric brain tumours, non-resectable due to brainstem localisation and diffusive growth. Patients with DIPG have a dismal prognosis of 9-12 months survival no effective therapy. Over 80% DIPGs harbour mutation in histone 3 (H3.3 or H3.1) resulting lysine methionine substitution (H3K27M). H3K27M causes global epigenetic alterations (a loss H3K27 trimethylation an increase acetylation) aberrant gene expression. To date,...
Abstract BACKGROUND The optimal management for children with recurrent choroid plexus carcinoma (CPC), is not established. We report two germline TP53 mutations, whose CPC relapses were managed marrow-ablative chemotherapy and oral biologically-targeted therapies. PATIENTS: Patient A: A 17 months old male presented non-metastatic bilateral CPC. de novo mosaic mutation was identified. After near-total resections, 16 of standard administered; 18 later, localized tumor growth developed, again...
Abstract INTRODUCTION: Diffuse pediatric-type high-grade gliomas are diffuse with histological features of malignancy, typically occurring in children, and infants. For these tumors, precise classification, identification prognostic predictive factors requires molecular analysis. The ROS proto-oncogene 1 (ROS1) gene encodes a receptor tyrosine kinase that is involved chromosomal rearrangements numerous malignancies, may be an attractive therapeutic target, since specific inhibitors have been...