A5101624079- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Nitric Oxide and Endothelin Effects
- Coronary Interventions and Diagnostics
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Hormonal Regulation and Hypertension
- Acute Myocardial Infarction Research
- Chronic Myeloid Leukemia Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- HER2/EGFR in Cancer Research
- Vitamin K Research Studies
- Cardiac tumors and thrombi
- Renin-Angiotensin System Studies
- Lipoproteins and Cardiovascular Health
- Health Promotion and Cardiovascular Prevention
- Health Policy Implementation Science
- Vascular Procedures and Complications
Montreal Heart Institute
1996-2023
Université de Montréal
1987-2015
Universität Ulm
2014
Division of Chemistry
2009
Hôpital Maison Blanche
2005
Royal Victoria Hospital
1998
Royal Victoria Regional Health Centre
1998
Centre National de la Recherche Scientifique
1996
Baylor College of Medicine
1995
University of California San Francisco Medical Center
1987
High-density lipoproteins (HDLs) have several potentially protective vascular effects. Most clinical studies of therapies targeting HDL failed to show benefits vs. placebo. To investigate the effects an HDL-mimetic agent on atherosclerosis by intravascular ultrasonography (IVUS) and quantitative coronary angiography (QCA). A prospective, double-blinded, randomized trial was conducted at 51 centres in USA, Netherlands, Canada, France. Intravascular QCA were performed assess baseline 3 (2–5)...
In the Studies of Left Ventricular Dysfunction (LVD), enalapril or placebo was administered in a double-blind fashion to 6797 participants with ejection fraction < = 0.35. During 40 months' average follow-up, 28.1% randomized reported side effects compared 16.0% group (p 0.0001). Enalapril use associated higher rate symptoms related hypotension (14.8% vs 7.1%, p 0.0001), azotemia (3.8% 1.6%, cough (5.0% 2.0%, fatigue (5.8% 3.5%, hyperkalemia (1.2% 0.4%, 0.0002), and angioedema (0.4% 0.1%,...
We have shown that probucol reduces restenosis after balloon angioplasty. Whether acted via prevention of neointimal formation or improvement in vascular remodeling could not be addressed by angiography and required the use intravascular ultrasound (IVUS).Beginning 30 days before angioplasty, 317 patients were randomly assigned to receive probucol, multivitamins, combined treatment, placebo. Patients then treated for 6 months IVUS examination was performed immediately angioplasty at...
Although transvenous pacemakers and implantable cardioverter-defibrillators (ICD) have long been the standard of care, they are not without significant drawbacks. In recent years, major advances achieved in leadless pacemaker technology1 entirely subcutaneous ICD (S-ICD) systems2 that obviate intracardiac leads hence carry potential to reduce associated complications. Unlike ICDs, S-ICD is devoid antibradycardia pacing capabilities. Nevertheless, certain patients, such as those lacking...
Although converting-enzyme inhibitors are useful for the treatment of congestive heart failure (CHF), there concems about adverse reactions especially on initiation therapy. In Studies Left Ventricular Dysfunction, enalapril, 2.5 mg twice per day was given an open-label outpatient basis 7 days (mean 6.1, range 2 to 7, and median 7) as a prerandomization drug challenge 7487 patients with left ventricular dysfunction (ejection fraction ≤0.35). Four hundred forty-four (5.93%) reported side...
Management of patients (pts) presenting syncope diverges markedly from the guidelines European Society Cardiology (ESC). To improve this management, easiest option seemed to be educate physicians. The aim study was evaluate impact an educational process on use unnecessary neurological investigations.Charts pts during two 12-month periods (1999-2000 and 2002-2003) emergency department were systematically reviewed. Between periods, all physicians in charge with attended meetings. During these...
Acute anterior wall myocardial infarction is a rare but often catastrophic presentation of ascending aortic dissection. We report the case patient who was successfully treated by direct stenting left main coronary artery, allowing for definitive surgical correction. Cathet. Cardiovasc. Intervent. 51:74–77, 2000. © 2000 Wiley-Liss, Inc.
BACKGROUND: Despite chronic therapies, atrial fibrillation (AF) leads to rapid ventricular rates (RVR) often requiring intravenous treatments. Etripamil is a fast-acting, calcium-channel blocker administered intranasally affecting the atrioventricular node within minutes. METHODS: Reduction of Ventricular Rate in Patients with Atrial Fibrillation evaluated efficacy and safety etripamil for reduction rate (VR) patients presenting urgently AF-RVR (VR ≥110 beats per minute [bpm]), was...
Shone’s anomaly, a congenital cardiac malformation complex, consists of multiple levels
 left heart obstruction. A rare case an incomplete form this anomaly discovered incidentally
 during catheterization for unrelated event is described.
Introduction: It was hypothesized that after a continuing medical education (CME) event, practice enablers and reinforcers addressing main clinical barriers to preventive care would be more effective in improving general practitioners' (GPs) adherence cardiovascular guidelines than CME event only. Methods: A cluster-randomized trial conducted on convenience sample of 122 GPs who were randomly assigned either only (control group) or with (PER group). In the PER group, nurses visited GPs'...
Angiotensin-converting enzyme (ACE) is present on the luminal surface of coronary vessels, mostly capillary endothelium. ACE also expressed smooth muscle cells and plaque lipid-laden macrophages. Excessive circulation (CC)-ACE activity might be linked to progression. Here we used biologically inactive substrate (3)H-labeled benzoyl-Phe-Ala-Pro ([(3)H]BPAP) quantify CC-ACE in 10 patients by means indicator-dilution technique. The results were compared with atherosclerotic burden determined...