A5086729299- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Blood properties and coagulation
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Platelet Disorders and Treatments
- Neurological Disorders and Treatments
- Immune cells in cancer
- Extracellular vesicles in disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Chromatin Remodeling and Cancer
- Organ Transplantation Techniques and Outcomes
- Alzheimer's disease research and treatments
- Cardiovascular Function and Risk Factors
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Ischemia and Reperfusion
- Phosphodiesterase function and regulation
- Anesthesia and Neurotoxicity Research
- Blood Coagulation and Thrombosis Mechanisms
University Hospital Münster
2016-2024
University Hospital Schleswig-Holstein
2020-2024
University of Lübeck
2020-2024
Fraunhofer Institute for High-Speed Dynamics, Ernst-Mach-Institut
2021-2023
Amsterdam Neuroscience
2021
Amsterdam University Medical Centers
2021
Netherlands Institute for Neuroscience
2021
University of Amsterdam
2021
Children's Hospital of Richmond at VCU
2020
Institute of Neuroimmunology of the Slovak Academy of Sciences
2018
Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined lymphocytes adipose and IR.In mouse model obesity-mediated IR, high-fat diet (HFD) induced IR already after 5 weeks, which was associated with marked T-lymphocyte infiltration visceral tissue. In contrast, recruitment macrophages delayed an increase MAC3-positive staining F4/80 mRNA expression 10 weeks HFD, suggesting dissociation macrophage invasion into...
Abstract Anti-glial fibrillary acidic protein (GFAP) meningoencephalomyelitis (autoimmune GFAP astrocytopathy) is a new autoimmune central nervous system (CNS) disease diagnosable by the presence of anti-GFAP autoantibodies in cerebrospinal fluid and presents as majority patients. Only few neuropathological reports are available little known about pathogenic mechanisms. We performed histopathological study two autopsies nine CNS biopsies patients with found predominantly lymphocytic one...
There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating resection cavity wall superparamagnetic iron oxide nanoparticles (“NanoPaste” technique). Patients underwent 1-h hyperthermia sessions alternating magnetic field and, if possible, received concurrent fractionated...
Summary Patients with diabetes mellitus are at increased risk of cardiovascular morbidity and mortality. Atherothrombosis, defined as atherosclerotic lesion disruption superimposed thrombus formation, is the most common cause death among these patients. Following plaque rupture, adherence platelets followed by local activation coagulation, formation a cross-linked fibrin clot development an occlusive platelet rich mesh. exhibit thrombotic clustering which composed hyper-reactive platelets,...
Background Numerous interactions between the coagulation and complement systems have been shown. Recently, links mannan-binding lectin-associated serine protease-1 (MASP-1) of lectin pathway proposed. Our aim was to investigate MASP-1 activation factor XIII (FXIII), fibrinogen, prothrombin, thrombin-activatable fibrinolysis inhibitor (TAFI) in plasma-based systems, analyse effects on plasma clot formation, structure lysis. Methodology/Principal Findings We used a FXIII incorporation assay...
Abstract Multiple sclerosis (MS) is the most frequent demyelinating disease and a leading cause for disability in young adults. Despite significant advances immunotherapies recent years, progression still cannot be prevented. Remyelination, meaning formation of new myelin sheaths after event, can fail MS lesions. Impaired differentiation progenitor cells into myelinating oligodendrocytes may contribute to remyelination failure and, therefore, development pharmacological approaches which...
Abstract Multiple sclerosis (MS) is the most frequent demyelinating disease in young adults and despite significant advances immunotherapy, progression still cannot be prevented. Promotion of remyelination, an endogenous repair mechanism resulting formation new myelin sheaths around demyelinated axons, represents a promising treatment approach. However, remyelination frequently fails MS lesions, which can part attributed to impaired differentiation oligodendroglial progenitor cells into...
Background and method: Increased plasma clot density prolonged lysis times are associated with cardiovascular disease. In this study, we employed a functional proteomics approach to identify novel components which may influence phenotypes. Results: Analysis of perfused, solubilised clots identified inflammatory proteins, including complement C3, as components. paired serum samples confirmed concentration-dependent incorporation C3 into clots. Surface plasmon resonance indicated high-affinity...
Identification of risk factors for perioperative epilepsy remains crucial in the care patients with meningioma. Moreover, associations brain invasion clinical and radiological variables have been largely unexplored. The authors hypothesized that cortex subsequent increased edema facilitate seizures, they compared data seizures brain-invasive or noninvasive
Abstract Rhabdoid phenotype and loss of SMARCB1 expression in a brain tumor are characteristic features atypical teratoid/rhabdoid tumors (ATRT). Rare non‐rhabdoid showing cribriform growth pattern have been designated neuroepithelial (CRINET). Small case series suggest that CRINETs may relatively favorable prognosis. However, the long‐term outcome is unclear it remains uncertain whether CRINET represents distinct entity or variant ATRT. Therefore, 10 were clinically molecularly...
Diabetes is associated with increased incidence of atherothrombotic disease. The fibrin network forms the backbone arterial thrombus, and clot structure determines predisposition to cardiovascular events.The aim study was investigate structure/fibrinolysis in largest type 2 diabetes cohort analyze associations cardiometabolic risk factors vascular pathology.Clot assessed 875 participants Edinburgh Type Study [age, 68 (range, 60-75) yr; 450 males] by turbidimetric assays, clots were...
Brain invasion (BI) in meningiomas impacts WHO grading and therefore adjuvant treatment. However, BI is rare neurosurgical sampling neuropathological analyses are not standardised. Moreover, associations with imaging findings sparsely known. Associations between on preoperative MRI were investigated 617 meningioma patients. was strongly correlated other high-grade criteria (p<.001). Presence of a contrast enhancing tumour capsule, disruption the arachnoid layer, intratumoural calcifications...
Abstract In this multi-institutional study we compiled a retrospective cohort of 86 posterior fossa tumors having received the diagnosis cerebellar glioblastoma (cGBM). All were reviewed histologically and subjected to array-based methylation analysis followed by algorithm-based classification into distinct classes (MCs). The single MC containing largest proportion 25 diagnosed as cGBM was anaplastic astrocytoma with piloid features representing recently-described molecular tumor entity not...
Abstract Background Inflammation of adipose tissue (AT) has been recently accepted as a first step towards obesity-mediated insulin resistance. We could previously show that mice fed with high fat diet (HFD) develop systemic resistance (IR) and glucose intolerance (GI) associated CD4-positive T-lymphocyte infiltration into visceral AT. These T-lymphocytes, when enriched in AT, participate the development inflammation subsequent recruitment proinflammatory macrophages. The aim this work was...
Hyperthyroidism is associated with increased thrombosis risk, and fibrin clot structure determines susceptibility to vascular thrombotic events.Our objective was investigate formation lysis in hyperthyroidism using observational interventional studies.Ex vivo structure/fibrinolysis plasma levels of thrombotic/inflammatory markers were investigated hyperthyroid individuals (n = 24) matched controls 19), turbidimetric assays, ELISA, confocal electron microscopy. The effects normalizing thyroid...