A5043026037- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Musculoskeletal pain and rehabilitation
- Pain Management and Opioid Use
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Botulinum Toxin and Related Neurological Disorders
- Epilepsy research and treatment
- Spine and Intervertebral Disc Pathology
- Pharmacological Receptor Mechanisms and Effects
- Pain Management and Treatment
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Pediatric Pain Management Techniques
- Cannabis and Cannabinoid Research
- Adenosine and Purinergic Signaling
- Cardiac, Anesthesia and Surgical Outcomes
- Treatment of Major Depression
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Respiratory Support and Mechanisms
- Cancer Treatment and Pharmacology
- Traumatic Brain Injury Research
- Osteoarthritis Treatment and Mechanisms
Uppsala University
2011-2024
Uppsala University Hospital
2004-2023
AstraZeneca (United Kingdom)
2014
AstraZeneca (Sweden)
2009-2013
Swedish Research Council
1992-1996
Medical Research Council
1992-1996
Institute of Cytology
1995
A strategy using mechanical chest compressions might improve the poor outcome in out-of-hospital cardiac arrest, but such a has not been tested large clinical trials.To determine whether administering with defibrillation during ongoing (mechanical CPR), compared manual cardiopulmonary resuscitation (manual according to guidelines, would 4-hour survival.Multicenter randomized trial of 2589 patients arrest conducted between January 2008 and February 2013 4 Swedish, 1 British, Dutch ambulance...
Post-sternotomy pain is sometimes a sequela of cardiac surgery. The incidence, characteristics and clinical course post-sternotomy are not well known. aim our study was to determine the incidence chronic in patients undergoing sternotomy for surgery general according specific surgical procedure.In prospective manner, group 349 consecutive were evaluated one year after asked postal questionnaire describe score any persistent following procedure. classified into 3 sub-groups first consisted...
Background: Pain following spinal cord injury (SCI) is a therapeutic challenge. Only few treatments have been assessed in randomized, controlled trials. The primary objective of the present study was to examine analgesic effect ketamine and lidocaine group patients with neuropathic pain below level injury. We also wanted assess sensory abnormalities see if this could help us identify responders resulted changes sensibility. Methods: Ten were included. 0.4 mg kg −1 2.5 investigated. Saline...
The effects of a TRPV1 antagonist (AZD1386) were investigated in patients with acute pain. After removal mandibular third molar and at request analgesia 103 randomly received 95 mg AZD1386 (n = 40), placebo 40) or 500 naproxen 23) double-blind manner. Plasma samples drawn, pain intensity body temperature measured during 8 h after drug administration. difference from intake was calculated as percentage (PID%) weighted sum over the (SPID%0-8 h). time to first perceptible meaningful relief...
Little is known about local and systemic biomarkers in relation to synovitis pain end-stage osteoarthritis (OA) patients. We investigated the associations between novel extracellular matrix biomarker, C1M, interleukin 6 (IL-6) with pain. Serum plasma, synovial fluid IL-6 (p-IL-6, sf-IL-6) were measured 104 knee OA Contrast-enhanced magnetic resonance imaging was used semiquantitatively assess an 11-point score; assessed by Western Ontario McMaster Universities Osteoarthritis Index (WOMAC)...
Plasma concentrations, maximum regional brain and specific binding in the after administration of 0, 0.1, 0.2 mg/kg doses (S)-ketamine were measured a randomized, double-blind, crossover study five volunteers related to induced effects such as analgesia, amnesia, mood changes. Specific was assessed by simultaneous (S)-[N-methyl-11C]ketamine quantified positron emission tomography. High radioactivities corresponded distribution N-methyl-D-aspartate receptor complexes. A significant...
Abstract: Adenosine administered to humans has been reported induce pain after intravenous administration. On the other hand adenosine analogues have shown possess antinociceptive effects peripheral and intrathecal administration in animals. The aim of present study was investigate effect agonists with different affinities for A1 A2 receptors on a persistent stimulus using formalin test. drugs chosen were, R‐phenylisopropyl‐adenosine (R‐PIA) high affinity receptor,...
R-phenylisopropyl-adenosine, which has an affinity for the adenosine A1 receptor higher than that A2 receptor, and N-ethylcarboxamide-adenosine, near equal receptors, were injected intrathecally into rats to evaluate differences in antinociceptive effect motor impairment. Using tail-immersion test, both compounds had effects. Motor function was evaluated during spontaneous movement a free space. N-ethylcarboxamide-adenosine rapidly impaired even after low intrathecal doses....
Background: Neuropathic pain is often severe and resistant to pharmacological treatment. The aims of the present study were assess analgesic effect ketamine lidocaine investigate if measurement different variables sensibility could be used identify responders. We also wanted treatment resulted in changes sensibility. Methods: Twelve patients with long‐lasting peripheral neuropathic traumatic origin included. effects hydrochloride (Ketalar ® , Parke Davis) 0.4 mg/kg (Xylocain Astra) 2.5...
Adenosine analogs injected intrathecally (IT) in rodents induce antinociceptive effects a variety of nociceptive tests [1-4]. Together with findings biochemical markers for adenosine formation, release and metabolism the dorsal horn, existence spinal receptors, this indicates role modulation nociception at level [5]. Of special interest are reports on effect IT mimicking neurogenic pain states [2-4]. Using strychnine, Sosnowski Yaksh [2] have demonstrated that inhibit behavior induced by...
Summary The aim of the present study was to investigate effects AZD 1940, a novel peripherally acting cannabinoid CB 1 / 2 receptor agonist, on capsaicin‐induced pain and hyperalgesia, as well biomarkers central nervous system ( CNS ) effects. randomized, double‐blind, placebo‐controlled, four‐sequence, two‐period, cross‐over in 44 male healthy volunteers aged 20–45 years. two single oral doses 1940 (400 800 μg) were compared with placebo. Pain intensity after intradermal capsaicin...
This behavioral study was performed in order to delineate the antinociceptive effects of and influence on motor function a highly potent, competitive NMDA receptor antagonist 3-(2-carboxypiperazin-4yl) propyl-1-phosphonic acid (CPP). After intrathecal (i.t.) administration CPP chronically catheterized rats, antinociception studied 3 different nociceptive tests: tail-flick test, hot-plate formalin test. The lowest dose producing visible dysfunction 1 nmol, with 2 8 animals showing slight...
The LUCAS™ device delivers mechanical chest compressions that have been shown in experimental studies to improve perfusion pressures the brain and heart as well augmenting cerebral blood flow end tidal CO2, compared with results from standard manual cardiopulmonary resuscitation (CPR). Two randomised pilot out-of-hospital cardiac arrest patients not improved outcome when CPR. There remains evidence small case series can be potentially beneficial specific situations. This multicentre study is...
In Sweden, as in many other countries, paramedics or nurses constitute the majority of prehospital personnel. If tasks usually performed by doctors are to be these personnel, there is a need for guidelines and triage handling medical emergencies. We describe an information management system used ambulances data communication, documentation, triaging presentation checklists. most cases, input while patient being cared for. The collected stored together with automatically received from...
Ropivacaine is a new local anaesthetic available for spinal and epidural anaesthesia. When drugs are being introduced application, their effect on cord blood flow (SCBF) should be studied safety toxicological aspects. In the present study, SCBF was after intrathecal (i.t.) application of ropivacaine bupivacaine with without epinephrine.SCBF measured continuously in spontaneously breathing, enflurane/N2O anaesthetized rats, using laser-Doppler flowmetry technique. The exposed by laminectomy...