A5016175058- Fluid Dynamics and Heat Transfer
- Inhalation and Respiratory Drug Delivery
- Electrohydrodynamics and Fluid Dynamics
- Combustion and flame dynamics
- Particle Dynamics in Fluid Flows
- Aerosol Filtration and Electrostatic Precipitation
- Plant Surface Properties and Treatments
- Granular flow and fluidized beds
- Advanced Combustion Engine Technologies
- Power Transformer Diagnostics and Insulation
- Biodiesel Production and Applications
- Advanced Drug Delivery Systems
- Optical Coherence Tomography Applications
- Cyclone Separators and Fluid Dynamics
- Fire dynamics and safety research
- Microencapsulation and Drying Processes
- Innovative Microfluidic and Catalytic Techniques Innovation
- Aerodynamics and Fluid Dynamics Research
- Combustion and Detonation Processes
- Catalytic Processes in Materials Science
- Fluid Dynamics and Mixing
- Microfluidic and Bio-sensing Technologies
- Lattice Boltzmann Simulation Studies
- Photoacoustic and Ultrasonic Imaging
- Infection Control and Ventilation
The University of Sydney
2015-2025
Macquarie University
2015-2023
University of Southampton
2009-2011
The in-situ gelation of thermosensitive nasal formulations with desirable spray characteristics at room temperature and ability to undergo a phase change semi-solid state mucoadhesive behavior physiological has the potential efficiently deliver therapeutics brain. However, their application in generation favorable not been investigated.Thermosensitive chitosan (CS)-based different viscosities were prepared for intranasal delivery ibuprofen using CS various molecular weights. formulation...
Abstract Air-assisted primary atomization is investigated in a configuration where liquid injected turbulent gaseous jet flow both within as well outside of the potential core. Cases are studied injection point moved to maintain range constant mean velocities but changing local fluctuating velocity root-mean-square (r.m.s.) levels. Over conditions, this allows for systematic understanding effects gas-phase turbulence and shear on break-up independently. Extensive data obtained analysed from...
Abstract The fundamental mechanisms responsible for the creation of electrohydrodynamically driven roll structures in free electroconvection between two plates are analysed with reference to traditional Rayleigh–Bénard convection (RBC). Previously available knowledge limited dimensions is extended three-dimensions, and a wide range electric Reynolds numbers analysed, extending into fully inherently three-dimensional turbulent regime. Results reveal that appearing electrohydrodynamics (EHD)...
Aerosol drug delivery in the human airway is significantly affected by morphology and size of airway. This work developed a CFD-DEM model to simulate analyze air flow powder dynamics combined inhaler-airway systems with different degrees deformation (non-deformed, 50%, 75% deformed) sizes (adult, 0.80, 0.62 scaled). The airways were generated based on regular constructed from MRI images through finite element method (for deformed airways) or scaling-down smaller airways). connected...
Backlight imaging is frequently used for the visualization of multiphase flows, where with appropriate microscope lenses, quantitative information on spray structure can be attained. However, a key issue resides in nature measurement which relies single viewing angle, hence preventing all liquid structures and features, such as those located behind other fragments. This paper presents results from an extensive experimental study aimed step forward towards resolving this problem by using pair...
Direct visualization of atomizing sprays using backlight imaging is commonly used to obtain both qualitative and quantitative information on spray morphology. Recently, the standard technique was extended 'dual-angle' by authors (Kourmatzis et al 2017 Meas. Sci. Technol. 28 035302), enable quantification volume arbitrarily shaped fragments accuracies order 10. In this contribution, dual-angle particle-tracking velocimetry (PTV) has been developed, hence extending our capability measure...
This study investigated a capsule's powder evacuation behavior when rotating about its minor axis in cross flow and considering the effects of rotation speed rate on emission. The experimental platform, an optically accessible capsule chamber, was designed to uncover independent these variables by enabling high-speed imaging evacuation. capsules were rotated at three speeds (1500, 2500, 3650 RPM) two constant rates, 30 SLPM 60 (inlet velocity: 16.67 m/s 33.33 m/s, respectively). Two powders...
Background: Understanding the geometries of human upper airway and their impact on drug particle transport is important. This study investigates inhaler mouthpiece size extrathoracic geometry across a diverse body mass index (BMI) range. Methods Materials: Magnetic resonance imaging (MRI) was performed 28 participants. Subjects were asked to bite replicas mouthpieces with incisal openings 13.5 mm 27 mm, effects analysed. Results: Mouthpiece affects oral space, results show significant linear...
A human nasal epithelial mucosa (NEM) on-a-chip is developed integrated with a novel carbon nanofibers-modified electrode for real-time quantitative monitoring of in vitro drug delivery. The integration platinum electrodes the chip also enables measurement transepithelial electrical resistance (TEER).The air-liquid interface culture RPMI 2650 cells NEM-on-a-chip was optimized to mimic key functional characteristics mucosa. transport ibuprofen electrochemically monitored under static and...
Powder dispersion in dry powder inhalers (DPIs) is affected by formulations as well the design of a device. This paper conducted numerical investigation based on coupled computational fluid dynamics (CFD) and discrete element method (DEM) to evaluate changes commercial DPI device Turbuhaler® aerosolization an API-only formulation. Six different designs were proposed modifying mouthpiece chamber original geometry which was reconstructed from CT-scan Turbuhaler, their performances terms...