A5034425497- Computational Drug Discovery Methods
- Molecular Sensors and Ion Detection
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Trace Elements in Health
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antifungal resistance and susceptibility
- Malaria Research and Control
- Protein Structure and Dynamics
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Plant Disease Resistance and Genetics
- Electrochemical Analysis and Applications
- Pharmacological Effects of Natural Compounds
- HIV/AIDS drug development and treatment
National University of Malaysia
2020-2021
University of Mataram
2020
Widespread resistance of Plasmodium falciparum to current artemisinin-based combination therapies necessitate the discovery new medicines. Pharmacophoric hybridization has become an alternative for drug that lowers risk drug-drug adverse interactions. In this study, we synthesized a series hybrids by covalently linking scaffolds pyrano[2,3-c]pyrazole with 4-aminoquinoline via ethyl linker. All hybrid molecules were evaluated through in vitro screenings against chloroquine-resistant (K1) and...
Malaria is a potentially deadly disease with many anti-malarial drugs have been rendered ineffective due to Plasmodium falciparum resistance concern.Plasmodium lactate dehydrogenase (PfLDH) enzyme crucial malaria parasite involved in the glycolytic pathway, thus, has considered as potential molecular target.Initially, docking was performed using AutoDock Vina, Molegro Virtual Docker, and CDOCKER software investigate interactions of 4-aminoquinoline antimalarial hybrids compounds PfLDH...
Aminoalkylated chalcone compounds (4a-4c) have been designed using Quantitative Structure-Activity Relationship (QSAR) analysis, synthesized and evaluated for their in vitro antimalarial activity.The best QSAR model obtained was log IC 50 = 705.132(qC7) -65.573 (qC3) -24.845 (qC4) -4.634 (qC13) -220.479 statistical analysis showed R 2 of 0.937, suggesting that the able to predict actual activity by 93.7% accuracy.The addition secondary amines successfully carried out Mannich reaction, which...
Abundant of preparatory works have recognized that fluorescent sensors based on 8-aminoquinoline are popular tools to detect Zn2+ ions in environmental and biological applications. Along with these studies, researchers started introduce a variety carboxamido group into an molecule forming 8-amidoquinoline derivatives. Therefore, this systematic review aims general overview the fluorophore as receptors provide comparisons collected studies related derivatives probe sensor. According PRISMA...
Six pyrano [2,3-c]pyrazole-3-carboxylate and quinoline derivatives (ACP 1A, ACP 1B, 1C, 1D, 2A 4A) synthesized screened for antimicrobial activity against two selected Gram-positive bacteria (Staphylococcus aureus Bacillus subtilis), three Gram-negative (Klebsiella pneumonia, Pseudomonas aeruginosa, Escherichia coli), yeast strains (Candida albicans Candida glabrata) filamentous fungi (Aspergillus niger Aspergillus fumigatus) using agar well diffusion method.Minimum inhibitory concentration...