A5061538620- Lysosomal Storage Disorders Research
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Parathyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiomyopathy and Myosin Studies
- Metabolism and Genetic Disorders
- Pluripotent Stem Cells Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Amino Acid Enzymes and Metabolism
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Peroxisome Proliferator-Activated Receptors
- Hormonal Regulation and Hypertension
- Renal and related cancers
- Cardiac electrophysiology and arrhythmias
- Reproductive Biology and Fertility
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Trypanosoma species research and implications
- Glycogen Storage Diseases and Myoclonus
- Cardiovascular Effects of Exercise
- Studies on Chitinases and Chitosanases
The University of Sydney
2020-2025
Westmead Hospital
2019-2025
Robert Bosch (Australia)
2020
Christ University
2020
Groups of amino acids, and some selected added to media used for culture pre-implantation embryos have previously been shown improve development in various ways including survival the blastocyst stage, increased cell number improved hatching. In this study, we cultured 1-cell mouse 5 days hatching stage isosmotic medium (270 mOsm/kg) at high density (10 embryos/10 μL), where autocrine/paracrine support occurs, low (1 embryo/100 is minimized compromised. When 400 μM L-Pro or 1 mM L-Gln was...
Abstract Aims Anderson–Fabry disease (AFD) is an X-linked disease, with cardiac involvement resulting in increased left ventricular (LV) wall thickness. Speckle tracking echocardiography analysis may be more sensitive the assessment of myocardial impairment AFD patients and have prognostic value. Our aim was to evaluate LV atrial (LA) dysfunction by traditional strain parameters utility. Methods results Fifty-six were age- sex-matched 56 healthy controls. global longitudinal (GLS) LA...
The prognosis of light-chain (AL) amyloidosis, a plasma cell dyscrasia, is largely determined by the presence cardiac involvement. Conventional staging achieved using biomarkers (high-sensitivity troponin, N-terminal pro-beta natriuretic peptide) and free difference (Mayo staging). We sought to evaluate role echocardiographic parameters as prognostic markers in AL amyloidosis examine their utility compared with conventional staging.Seventy-five consecutive patients reviewed at referral...
Fabry disease (FD) is an X-linked disorder with α-galactosidase A deficiency. Males (>30 years) and females (>40 often present cardiac manifestations, predominantly left ventricular hypertrophy (LVH). The aim of this study was to evaluate electrocardiographic (ECG) characteristics within FD patients identify gender related differences, additionally explore the association ECG parameters structural functional alterations on transthoracic echocardiography (TTE). Retrospective cross-sectional...
Ischaemic stroke frequently has a cardioembolic (CE) source. Clinical and echocardiographic parameters associated with CE were evaluated.In all, 93 consecutive ischaemic patients who underwent transthoracic echocardiogram retrospectively analysed; strokes classified by TOAST (Trial of Org 10172 in Acute Stroke Treatment) criteria. Echocardiographic related to stroke, including left atrial volumes function, compared 73 healthy controls.Of (mean age 66.1 years, 56% male), nine (10%) had large...
Ventricular arrhythmias (VA) portend a poor prognosis in non-ischemic cardiomyopathy (NICM). In this meta-analysis we evaluated if left ventricular (LV) global longitudinal strain (GLS) and LV mechanical dispersion (LVMD) are associated with VA, specifically NICM patients.A systematic review was performed to determine the predictive value of GLS LVMD for VA patients. endpoints were composite sudden cardiac death, events (including tachycardia or fibrillation), arrest appropriate implantable...
L-proline (Pro) has previously been shown to support normal development of mouse embryos. Recently we have that Pro improves subsequent embryo when added fertilisation medium during in vitro oocytes. The mechanisms by which are still being elucidated but likely involve signalling pathways observed Pro-mediated differentiation embryonic stem cells. In this study, show B0AT1, a neutral amino acid transporter accepts Pro, is expressed preimplantation embryos, along with the accessory protein...
Abstract Background Cardioembolism (CE) contributes to a large proportion of ischaemic stroke. Aims To evaluate the demographic and clinical profile CE stroke in Western Sydney. Methods A retrospective analysis patients presenting Westmead Hospital (January–October 2016) was performed. Strokes were classified by TOAST (Trial Org 10172 Acute Stroke Treatment) criteria into different categories. Clinical data collected on all patients, differences between other causes identified. Results Two...
Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)
Key Teaching Points•While polymorphic ventricular tachycardia is a life-threatening complication of atrioventricular junction catheter ablation for atrial fibrillation, we describe the first case seen after radiofrequency typical cavotricuspid-dependent flutter.•Risk factors development arrhythmias flutter have not been investigated; however, similar to they may include dilated cardiomyopathy and structural heart disease.•Prolonged repolarization in context an abrupt reduction rate should...
Abstract Background Prognosis in light chain (AL) amyloidosis is largely determined by the severity of cardiac involvement. Conventional (Mayo) staging includes 1) hs troponin 2) N-terminal pro-beta natriuretic peptide (NT-pro BNP) and 3)free difference. Methods In a retrospective study 75 AL patients referred to quaternary amyloid clinic, all underwent comprehensive echocardiographic assessment. Echocardiographic parameters included left ventricular (LV) ejection fraction, LV mass,...