A5022651085- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- Orthopaedic implants and arthroplasty
- Ion-surface interactions and analysis
- Semiconductor materials and devices
- Advanced materials and composites
- Wood Treatment and Properties
- Bone Tissue Engineering Materials
- Orthopedic Infections and Treatments
- Lignin and Wood Chemistry
- Osteoarthritis Treatment and Mechanisms
- High-pressure geophysics and materials
- Natural Fiber Reinforced Composites
- X-ray Spectroscopy and Fluorescence Analysis
- Total Knee Arthroplasty Outcomes
- Neuroscience and Neural Engineering
- Dental materials and restorations
- Salivary Gland Disorders and Functions
- Electrical and Bioimpedance Tomography
- EEG and Brain-Computer Interfaces
- Tribology and Wear Analysis
- Advanced ceramic materials synthesis
- Nuclear Physics and Applications
- Thermochemical Biomass Conversion Processes
- Lubricants and Their Additives
University of Eastern Finland
2016-2025
Finland University
2012-2025
University of Helsinki
1994-2024
Oulu University Hospital
2024
University of Oulu
2024
Kuopio University Hospital
2010
GTx (United States)
2005
Biomatériaux et Bioingénierie
2005
Helsinki Institute of Physics
1986-2000
Cornell University
1990-1993
Quantitative magnetic resonance imaging (MRI) techniques have earlier been developed to characterize the structure and composition of articular cartilage. Particularly, Gd-DTPA(2-)-enhanced T1 is sensitive cartilage proteoglycan content, while T2 relaxation time mapping indicative integrity arrangement collagen network. However, ability these detect early osteoarthrotic changes in has not demonstrated. In this study, normal spontaneously degenerated bovine patellar samples (n=32) were...
Normal bone remodeling and pathological destruction have been considered to be osteoclast-driven. Osteoclasts are able attach bare surface produce an acidic subcellular space. This leads acid dissolution of hydroxyapatite, allowing cathepsin K degrade the organic type I collagen-rich osteoid matrix under condition prevailing in Howship lacunae. Using a sting pH electrode, interface membrane around loosened total hip replacement prosthesis was found acidic. Confocal laser scanning disclosed...
Summary Recently, a number of portable devices designed for full polysomnography at home have appeared. However, current scalp electrodes used electroencephalograms are not practical patient self‐application. The aim this study was to evaluate the suitability recently introduced forehead electroencephalogram electrode set and supplementary chin electromyogram sleep staging. From 31 subjects (10 male, 21 female; age 31.3 ± 11.8 years), recorded simultaneously with standard setup consisting...
The analysis of the salivary metabolomic profile may offer an early phase approach to assess changes associated with a wide range diseases including head and neck cancer. aim present study was investigate potential nuclear magnetic resonance (NMR) spectroscopy for detecting metabolic squamous cell carcinoma (HNSCC). Unstimulated whole-mouth saliva samples collected from HNSCC patients (primary tumour located either in larynx or oral cavity) healthy controls were analysed by 1H-NMR...
Abstract Wear‐debris–induced periprosthetic bone loss and aseptic loosening is regarded as the main long‐term problem of total hip replacements (THRs). In this study amount wear debris from articulating surfaces THRs was reduced so to be close negligible by use high‐quality amorphous diamond (AD) coatings deposited pulsed plasma arc techniques. The rates determined in a commercial simulator for 15 million walking cycles (corresponding about years clinical use) serum lubrication were even...
Diamond has many superior, desired characteristics of implant materials such as low friction, high wear and corrosion resistance, well bonding surface to bone. The potential diamond for total hip replacement implants was studied in the form amorphous coatings on conventional metal materials. Amorphous (sp3 fraction 80%, thickness 0.2 10 microns) were deposited stainless steel AISI316L, Ti6A14V, CoCrMo alloys using filtered pulsed plasma are discharge method. Superior attachment achieved by...
The attachment of high‐quality amorphous diamond (a‐D) coatings has been studied with respect to the hardness underlying layer. A novel intermediate‐layer technique is reported that enables thick a‐D be deposited successfully on all solids at room temperature. Figure shows an film, a 1.2 μm layer Al, cracked but not delaminated after silicon‐wafer substrate was bent. magnified image
Abstract Toll‐like receptors (TLRs) have been known to act as sensors of innate immunity and respond ligands microbial endogenous components. Tissues cells typical for interface membrane foreign body reaction were analyzed evaluate potential role TLRs in the pathogenesis so called “aseptic loosening total hip replacement.” Fourteen cases around aseptic loose replacement implants stained by single double immunohistochemical methods examine cellular localization toll‐like receptor (TLR)‐4...