A5056130861- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Nutritional Studies and Diet
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Ion Channels and Receptors
- Health, Environment, Cognitive Aging
- interferon and immune responses
- Essential Oils and Antimicrobial Activity
- melanin and skin pigmentation
- Eosinophilic Esophagitis
- Herbal Medicine Research Studies
- Circadian rhythm and melatonin
- Acne and Rosacea Treatments and Effects
- Skin Protection and Aging
- Cytokine Signaling Pathways and Interactions
- Exercise and Physiological Responses
- Gut microbiota and health
- Immune Response and Inflammation
National Institute of Allergy and Infectious Diseases
2023-2025
National Institutes of Health
2023-2025
We recently used EPA databases to identify that isocyanates, most notably toluene diisocyanate (TDI), were the pollutant class with strongest spatiotemporal and epidemiologic association atopic dermatitis (AD). Our findings demonstrated isocyanates like TDI disrupted lipid homeostasis modeled benefit in commensal bacteria Roseomonas mucosa through disrupting nitrogen fixation. However, has also been established activate transient receptor potential ankyrin 1 (TRPA1) mice thus could directly...
Atopic dermatitis (AD) is a chronic, inflammatory disease characterized by dry, pruritic skin. In the U.S., prevalence of AD has increased over three-fold since 1970s. We previously reported geographic association between isocyanate-containing air pollution and as well mechanistic data demonstrating that isocyanates induce skin dysbiosis activate host itch receptor TRPA1. However, non-spatial models are susceptible to spatial confounding may overlook other meaningful associations.
BackgroundBetter understanding of the interaction between metabolism and immune response will be key to physiology disease. Tumor Necrosis Factor-alpha (TNFα) has been studied widely. However, despite extensive knowledge about TNFα, cytokine appears induce not only variable, but often contradictory, effects on inflammation cell proliferation. Despite advancements in metabolomics field, it is still difficult analyze types multi-dose, multi-time point studies needed for elucidating varied...
We tested the hypothesis that e-cigarette aerosol is metabolized by indigenous oral microbiome, leading to structural and functional alterations. combined untargeted metabolomics of in vitro commensal-rich pathogen-rich biofilms with metatranscriptomics fluorescent microscopy verified results human samples. Spectral deconvolution 4215 peaks identified 969 exposomal endogenous metabolites mapped 23 metabolic pathways. The clustered both characteristics biofilm composition; several were saliva...
Compared to the myriad of known triggers for rhinitis and asthma, environmental exposure research atopic dermatitis (AD) is not well established. We recently reported that an untargeted search U.S. Environmental Protection Agency (EPA) databases versus AD rates by United States (U.S.) postal codes revealed isocyanates, such as toluene diisocyanate (TDI), are pollutant class with strongest spatiotemporal epidemiologic association AD. further demonstrated (di)isocyanates disrupt...
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a major public health burden. Emerging antibiotic resistance has heightened the need for new treatment approaches MRSA infection such as developing novel antimicrobial agents and enhancing host’s defense response. The thermo-ion channels Transient Receptor Potential (TRP-) A1 V1 have been identified modulators of S. quorum sensing in cell culture models. However, their effects on vivo control unknown. In this study,...
Background Despite the recent expansion of treatment options in atopic dermatitis (AD), most management responsibilities fall on patient and/or caregivers. Disease control often requires vigilance about and avoidance common exposures, however concerns for patients caregivers living with AD have not been well enumerated. Methods An IRB approved survey was distributed to public evaluate caregiver topical exposures potential triggers. Results 323 people accessed link 259 providing response at...
Topical corticosteroids (TCS) are first-line therapies for numerous skin conditions. Steroid Withdrawal (TSW) is a controversial diagnosis advocated by patients with prolonged TCS exposure who report severe systemic reactions upon treatment cessation. However, to date there have been no systematic clinical or mechanistic studies distinguish TSW from other eczematous disorders.
Abstract Background Topical glucocorticoids (more commonly termed topical corticosteroids; TCS) are first line therapy for management of numerous skin conditions. Steroid Withdrawal (TSW) is a controversial diagnosis advocated by patients with prolonged TCS exposure who report severe systemic reactions upon treatment cessation. Although the disease may be confused eczematous disorders or dismissed outright, there have been no systematic clinical mechanistic studies to either refute support...
<title>Abstract</title> E-cigarettes have emerged as an exposomal factor of great concern to human health. We aimed test the hypothesis that e-cigarette aerosol is metabolized in oral cavity by indigenous microbiome, leading structural and functional alterations biofilms. combined untargeted metabolomic analysis <italic>in vitro</italic> commensal-rich pathogen-rich microcosm communities with metatranscriptomics, fluorescent microscopy, verified results samples. Spectral deconvolution 4,215...