A5062999745- Lipid Membrane Structure and Behavior
- Protein Structure and Dynamics
- RNA Research and Splicing
- Spectroscopy and Quantum Chemical Studies
- Lipid metabolism and biosynthesis
- RNA Interference and Gene Delivery
- Nanopore and Nanochannel Transport Studies
- Advanced Thermodynamics and Statistical Mechanics
- Metabolomics and Mass Spectrometry Studies
- RNA and protein synthesis mechanisms
University of Rochester Medical Center
2022-2024
The “lipid raft” hypothesis proposes that cell membranes contain distinct domains of varying lipid compositions, where “rafts” ordered lipids and cholesterol coexist with disordered regions. Experimental theoretical phase diagrams model have revealed multiple coexisting phases. Molecular dynamics (MD) simulations can also capture spontaneous separation bilayers. However, these methods merely determine the sign free energy change upon separation—whether or not it is favorable—but amplitude....
Liquid-liquid phase separation (LLPS) inside the cell often results in biological condensates that can critically impact homeostasis. Such events occur multiple parts of cells, including membranes, where so-called "lipid raft" hypothesis posits formation ordered domains floating a sea disordered lipids. The resulting lipid have functional roles. However, thermodynamics and their mechanistic effects on function dysfunction are poorly understood. Understanding such complex phenomena with...