A5073971310- Caveolin-1 and cellular processes
- Protein Tyrosine Phosphatases
- Ubiquitin and proteasome pathways
- Protein Kinase Regulation and GTPase Signaling
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Innovation and Socioeconomic Development
- Galectins and Cancer Biology
- Inflammatory mediators and NSAID effects
- Microtubule and mitosis dynamics
- Erythrocyte Function and Pathophysiology
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- CRISPR and Genetic Engineering
ShanghaiTech University
2019-2024
Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a multi-layered signaling network in time- space-dependent manner. Dysregulation of this post-translational modification is inevitably associated with pathological diseases. Our previous work has demonstrated that non-receptor kinase FER upregulated ovarian cancer, knocking down which attenuates metastatic phenotypes. However, due to the limited number known substrates cancer context, molecular basis for...
Metastasis is the leading cause of high ovarian-cancer-related mortality worldwide. Three major processes constitute whole metastatic cascade: invasion, intravasation, and extravasation. Tumor cells often reprogram their metabolism to gain advantages in proliferation survival. However, whether how those metabolic alterations contribute invasiveness tumor has yet be fully understood. Here we performed a genome-wide CRISPR-Cas9 screening identify genes participating cell dissemination revealed...
Abstract THEMIS plays an indispensable role in T cells, but its mechanism of action is highly controversial. Using the systematic proximity labeling methodology PEPSI, we identified as uncharacterized substrate for phosphatase SHP1. Saturated mutagenesis analysis revealed that phosphorylation at evolutionally conserved Tyr34 residue was oppositely regulated by SHP1 and kinase LCK. Like -/- mice, Y34F/Y34F knock-in mice showed a significant decrease CD4 thymocytes mature normal thymic...
Abstract Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a multi-layered signaling network in time space dependent manner. Dysregulation of this post-translational modification is inevitably associated with pathological diseases. Our previous work has demonstrated that non-receptor kinase FER upregulated ovarian cancer. Knockdown the attenuates metastatic phenotypes tumor cells. Here we employed mass spectrometry biochemical approaches to identify IRS4...