A5020737967- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Enzyme Structure and Function
- Biochemical effects in animals
- X-ray Diffraction in Crystallography
- Metal-Catalyzed Oxygenation Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Biomedical and Engineering Education
- DNA and Biological Computing
- Genetics, Bioinformatics, and Biomedical Research
- Biosensors and Analytical Detection
- Genomics and Phylogenetic Studies
- Radioactive element chemistry and processing
- Metabolomics and Mass Spectrometry Studies
- Microbial bioremediation and biosurfactants
- interferon and immune responses
- Crystallography and molecular interactions
International Institute of Molecular and Cell Biology
2019-2024
Max Planck Institute for Biophysical Chemistry
2016
Abstract SARS-CoV-2 is a betacoronavirus with linear single-stranded, positive-sense RNA genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of coronaviruses to rapidly evolve, adapt, and cross species barriers makes development effective durable therapeutic strategies challenging urgent need. As for other viruses, genomic structures are expected play crucial roles in several steps coronavirus replication cycle. Despite this, only handful functionally-conserved...
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, structures are predicted by modeling groups before publication experimental structures. We report large-scale set predictions 18 for 23 RNA-Puzzles: 4 elements, 2 Aptamers, Viral 5 Ribozymes 8 Riboswitches. describe automatic assessment protocols comparisons between prediction experiment. Our analyses reveal some critical...
RNA is a unique biomolecule that involved in variety of fundamental biological functions, all which depend solely on its structure and dynamics. Since the experimental determination crystal structures laborious, computational 3D prediction methods are experiencing an ongoing thriving development. Such can lead to many models; thus, it necessary build comparisons extract common structural motifs for further medical or studies. Here, we introduce pipeline dedicated reference-free...
Deoxyribozymes, DNA enzymes or simply DNAzymes are single-stranded oligo-deoxyribonucleotide molecules that, like proteins and ribozymes, possess the ability to perform catalysis. Although have not yet been found in living organisms, they isolated laboratory through vitro selection. The selected DNAzyme sequences catalyze a broad range of chemical reactions, utilizing DNA, RNA, peptides small organic compounds as substrates. DNAmoreDB is comprehensive database resource for that collects...
Summary SARS-CoV-2 is a betacoronavirus with linear single-stranded, positive-sense RNA genome of ∼30 kb, whose outbreak caused the still ongoing COVID-19 pandemic. The ability coronaviruses to rapidly evolve, adapt, and cross species barriers makes development effective durable therapeutic strategies challenging urgent need. As for other viruses, genomic structures are expected play crucial roles in several steps coronavirus replication cycle. Despite this, only handful functionally...
Abstract Nucleic acid cleaving DNAzymes are versatile and robust catalysts that outcompete ribozymes protein enzymes in terms of chemical stability, affordability ease to synthesize. In spite their attractiveness, the choice which DNAzyme should be used cleave a given substrate is far from obvious, requires expert knowledge as well in-depth literature scrutiny. DNAzymeBuilder enables fast automatic assembly for first time, superseding manual design DNAzymes. relies on an internal database...
SARS-CoV-2 is a betacoronavirus with linear single-stranded, positive-sense RNA genome of ~30 kb, whose outbreak caused the still ongoing COVID-19 pandemic. The ability coronaviruses to rapidly evolve, adapt, and cross species barriers makes development effective durable therapeutic strategies challenging urgent need. As for other viruses, genomic structures are expected play crucial roles in several steps coronavirus replication cycle. Despite this, only handful functionally conserved...
Abstract The outbreak of the COVID-19 pandemic has led to intensive studies both structure and replication mechanism SARS-CoV-2. In spite some secondary experiments being carried out, 3D key function regions viral RNA not yet been well understood. At beginning breakout, RNA-Puzzles community attempted envisage three-dimensional 5′- 3′-Un-Translated Regions (UTRs) SARS-CoV-2 genome. Here, we report results this prediction challenge, presenting methodologies developed by six participating...