A5019462942- Chemistry and Stereochemistry Studies
- Tropical and Extratropical Cyclones Research
- Nanoparticles: synthesis and applications
- Ocean Waves and Remote Sensing
- Oceanographic and Atmospheric Processes
- Advanced Wireless Communication Technologies
- UAV Applications and Optimization
- Advanced Photocatalysis Techniques
- Cell death mechanisms and regulation
- Reproductive System and Pregnancy
- Ultrasonics and Acoustic Wave Propagation
- Heavy Metal Exposure and Toxicity
- Coastal and Marine Dynamics
- NMR spectroscopy and applications
- Advanced Nanomaterials in Catalysis
- Distributed Control Multi-Agent Systems
- Agriculture, Soil, Plant Science
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Nanocomposite Films for Food Packaging
- Environmental Changes in China
- Advanced Cellulose Research Studies
- Aerospace and Aviation Technology
- Arctic and Antarctic ice dynamics
- Air Traffic Management and Optimization
Tibet University
2024
Changsha University of Science and Technology
2022-2023
Hainan Modern Women and Children's Hospital
2023
East China Normal University
2020-2022
Zhuhai Fudan Innovation Research Institute
2021-2022
Fudan University
2021-2022
Hainan Medical University
2021
California NanoSystems Institute
2018-2020
University of California, Los Angeles
2015-2020
Shenyang Jianzhu University
2018
We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction band energy levels delineate their toxicological potential at cellular and whole animal levels. Among the materials, overlap of (Ec) with redox (−4.12 −4.84 eV) was strongly correlated ability Co3O4, Cr2O3, Ni2O3, Mn2O3, CoO induce oxygen radicals, oxidative stress, inflammation. This outcome premised on permissible electron transfers from biological couples maintain equilibrium semiconductor...
We demonstrate through PdO doping that creation of heterojunctions on Co3O4 nanoparticles can quantitatively adjust band-gap and Fermi energy levels to study the impact metal oxide nanoparticle semiconductor properties cellular redox homeostasis hazard potential. Flame spray pyrolysis (FSP) was used synthesize a library in which gradual increase content (0-8.9%) allowed electron transfer from align across heterojunctions. This alignment accompanied by free hole accumulation at interface...
Abstract Nanocellulose is increasingly considered for applications; however, the fibrillar nature, crystalline phase, and surface reactivity of these high aspect ratio nanomaterials need to be safe biomedical use. Here a comprehensive analysis impact cellulose nanofibrils (CNF) nanocrystals (CNC) performed using materials provided by Nanomaterial Health Implications Research Consortium National Institute Environmental Sciences. An intermediary length also derived acid hydrolysis. While all...
Abstract The mononuclear phagocyte system in the liver is a frequent target for nanoparticles (NPs). A toxicological profiling of metal‐based NPs performed Kupffer cell (KC) and hepatocyte lines. Sixteen are provided by Nanomaterial Health Implications Research Consortium National Institute Environmental Sciences to study effects KUP5 Hepa 1–6 cells. Five (Ag, CuO, ZnO, SiO 2 , V O 5 ) exhibit cytotoxicity both types, while induce IL‐1β production KC. Ag, ZnO induced caspase 3 generated...
Abstract. Estuarine saltwater intrusions are mainly controlled by river discharge and tides. Unexpectedly, an extremely severe intrusion event occurred in February 2014 the Changjiang estuary under normal conditions. This cut off freshwater input for 23 d into Qingcaosha reservoir, which is largest estuarine reservoir world, creating a threat to water safety Shanghai. No similar catastrophic has since records of salinity have been kept. During event, persistent strong northerly wind existed,...
While it is well known that there are interspecies differences in Ag sensitivity, the cytotoxic responses of mammalian cells to silver nanoparticles (Ag NPs) also observed. In order explore these response outcomes, six cell lines, including epithelial (Caco-2, NHBE, RLE-6TN, and BEAS-2B) macrophages (RAW 264.7 THP-1) human rodent origin, exposed 20 nm citrate- PVP-coated NPs with Au cores, as citrate-coated particles without cores. An MTS assay shows while Caco-2 NHBE resistant over a 0.1-50...
We recently described that there is a feedback amplification of cytochrome c release from mitochondria by caspases. Here we investigated how caspases impact on to induce and found recombinant caspase‐3 induced opening permeability transition pore reduction membrane potential in vitro. These events were inhibited Bcl‐xL, cyclosporin A z‐VAD.fmk. Moreover, stimulated the rate mitochondrial state 4 respiration, superoxide production NAD(P)H oxidation Bcl‐xL‐ A‐inhibitable manner. results...
Abstract Carbon nanotubes (CNTs) exhibit a number of physicochemical properties that contribute to adverse biological outcomes. However, it is difficult define the independent contribution individual without purified materials. A library highly single‐walled carbon (SWCNTs) different lengths prepared from same base material by density gradient ultracentrifugation, designated as short (318 nm), medium (789 and long (1215 nm) SWCNTs. In vitro screening shows length‐dependent interleukin‐1β...
In order to represent the mechanical response laws of high-modulus asphalt pavement (HMAP) faithfully and objectively, viscoelasticity mixture (HMAM) was considered, viscoelastic responses were calculated systematically based on moving load by numerical simulations. The performances HMAP in resistance deformation cracking at bottom layer compared with ordinary pavement. Firstly, Lubao Honeywell 7686 (H7686) selected as high modulus modifiers. laboratory investigations Asphalt mix-70...
Abstract To improve navigation, the deep waterway project (DWP) was implemented in North Passage of Changjiang Estuary 1998, which includes a channel and two dikes protecting it. By altering estuarine morphology, DWP can affect saltwater intrusion mixing, with implications for drinking water intake supply. In this study, we employ numerical model to study influence on estuary under climatic persistent strong northerly wind conditions that occurred February 2014. The results show prevent...
Summary Aim Poststroke depression ( PSD ) is one of the most common neuropsychiatric complications after stroke. TREK ‐1, a two‐pore‐domain potassium channel, has been implicated in pathogenesis stroke and depression. The aim this study was to investigate whether ‐1 plays role therapeutic effects selective serotonin reuptake inhibitor SSRI escitalopram rat model. Methods whole‐cell patch‐clamp technique performed assess effect on recombinant TREK‐1 currents HEK293 cells. expression mRNA...
Abstract Saltwater intrusion in the Changjiang Estuary occurs winter and dry season, which may affect drinking water supply Shanghai. An atypical saltwater event, observed under high river discharge (>20,000 m 3 /s) October 2018, coincided with passage of super typhoon Kong‐rey. The response estuarine salt field is reproduced here a numerical model for analysis Eulerian framework. Model results show that was mainly due to landward advection (∼260 t/s), driven by storm surge (∼0.4 m) Ekman...
We attempt to investigate and study the clinical efficacy of letrozole combined with Li Shenbao treatment in patients ovarian hyporesponsiveness improve effect patients. selected 153 a hospital from January 2018 December 2020 as objects divided them into 2 groups according when they enter vitro fertilization assisted pregnancy cycle. Control group consists 76 treated antagonist protocol, while observation 77 treatment. The outcomes low were assessed compared. results showed that possessed...
This study assessed the impacts of in vitro culture times cleavage embryos on clinical pregnancy outcomes.This retrospective cohort was performed at Reproductive Medicine Department Hainan Modern Women and Children's Hospital China between January 2018 December 2022. Patients who first underwent frozen embryo transfer with fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles day 3 were included. According to time after thawing, divided into long-term group(18-20 h) short-term...
The high altitude area of Xizang has rich solar energy resources due to its unique geological conditions and climate environment. In order better utilize develop these resources, as well study their impact on the earth's ecosystem, it is necessary conduct in-depth observation research spectrum. field mainly conducted spectral observations three areas with an more than 5000m in around summer solstice 2022 2023, compared spectrum Daxing District Beijing (altitude 30.00m), Chengguan Lhasa...
In article number 2000528, André E. Nel, Tian Xia, and co-workers show how metal-based nanoparticles are taken up by liver cells including Kupffer hepatocytes, where they induce tiered oxidative stress responses mitochondrial reactive oxygen species generation, glutathione depletion, expression of phase II enzymes such as HO-1, production pro-inflammatory cytokines IL-1β TNF-α, cell death via different mechanisms apoptosis (Ag, CuO, ZnO, V2O5) pyroptosis (fumed SiO2).
Background: Venous thromboembolic events (VTE) are common causes of morbidity and mortality in glioblastoma patients. Mutation the isocitrate dehydrogenase 1 enzyme (IDH1) is frequent secondary results altered metabolomics. Objectives: This study evaluates whether IDH-1 status correlates with incidence VTE Methods: Observational 398 cases patients glioblastoma, who all underwent surgery a regional Neurosurgical centre between April 2012 December 2014. IDH -1 Tissue factor (F3) protein...
To estimate the value of blastocyst culture for preimplantation genetic diagnosis (PGD).Day 3 embryos were biopsied and analyzed with fluorescence in situ hybridization (FISH) technique. Embryos normal FISH results cultured into blastocysts, ones better morphology scores transferred. Fourteen abnormal blastocysts. Part cells taken from blastocysts amplified by whole genomic amplification (WGA) assessed array-based comparative (array-CGH) analysis.Six transferred 5 cycles. Four healthy babies...