A5018428016- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Biochemical effects in animals
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Aldose Reductase and Taurine
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Electrochemical Analysis and Applications
- Nitric Oxide and Endothelin Effects
- Memory and Neural Mechanisms
- Molecular Biology Techniques and Applications
- Liver Disease and Transplantation
- Neurotransmitter Receptor Influence on Behavior
- Human Health and Disease
- Epilepsy research and treatment
- Biomedical Ethics and Regulation
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
- Coconut Research and Applications
- Neurogenesis and neuroplasticity mechanisms
Tbilisi State University
1997-2021
Heinrich Heine University Düsseldorf
1997-2009
Russian Academy of Sciences
1995
Orexins/hypocretins (OX/Hcrt) are hypothalamic neuropeptides linking sleep-wakefulness, appetite and neuroendocrine control. Their role mechanisms of action on higher brain functions, such as learning memory, not clear.We used field recordings excitatory post-synaptic potentials (fEPSP) in acute mouse slice preparations to study the effects orexins pharmacological inhibitors multiple kinases long-term synaptic plasticity hippocampus.Orexin-A (OX-A) but orexin-B (OX-B) induces a...
Abstract Taurine occurs at high concentrations in the forebrain and its distribution varies with (patho)physiological conditions; however, role neural function is poorly understood. We have now characterized effects on corticostriatal synaptic transmission. Bath application of taurine (10 m ) to slices obtained from mice rats exerted a biphasic action field potentials. The fast reversible inhibition by was accompanied depolarization conductance increase medium spiny neurons sensitive...
Taurine, a major osmolyte in the brain evokes long-lasting enhancement (LLETAU) of synaptic transmission hippocampal and cortico-striatal slices. Hippocampal LLETAU was abolished by GABA uptake blocker nipecotic acid (NPA) but not taurine-uptake inhibitor guanidinoethyl sulphonate (GES). Striatal sensitive to GES NPA. Semiquantitative PCR analysis immunohistochemistry revealed that taurine transporter expression is significantly higher striatum than hippocampus. Taurine transporter-deficient...
In models of early stage Parkinson's disease (PD), motor deficits are accompanied by excessive activation striatal glutamate receptors. Metabotropic group I receptors (mGluR I) play an important but not well-understood role in PD progression. mouse brain slices, bath application the mGluR agonist (RS)-DHPG (3,5-dihydroxyphenylglycine, 100 microm for 20 min) caused a long-term depression corticostriatal transmission (LTD(DHPG)), which was reversed three antagonists: LY 367385, CPCCOEt and...
Cu2+-ions are known to interfere with γ-aminobutyric acid (GABA)- and glutamate-operated ion channels from experiments isolated neurons. Such actions likely involved in the pathophysiology of Wilson's disease. We have now studied effects Cu2+ CA 1 region hippocampal slices. Field excitatory postsynaptic potential (EPSP) slopes CA1 were unaffected by μM but depressed 10 (to 85%) 100 50%). A paired-pulse test revealed no difference facilitation presence or absence Cu2+, indicating a action....
Abstract Mossy fiber long‐term potentiation (mfLTP) was compared in hippocampal slices prepared from wild‐type mice and lacking functional endothelial nitric oxide synthase (eNOS ‐/‐ mice) using field potential recording. In the presence of D‐2‐amino‐5‐phosphonovaleric acid (AP5, 50 μM), mfLTP induced by tetanic stimulation (100 Hz, 1 sec) significantly reduced knockouts (n = 8) comparison with 8). Similarly, forskolin (30 μM) or 8‐bromo‐cyclic adenosine monophosphate (8‐Br‐cAMP, 100 less...
Cu2+-ions are known to interfere with γ-aminobutyric acid (GABA)- and glutamate-operated ion channels from experiments isolated neurons. Such actions likely involved in the pathophysiology of Wilson's disease. We have now studied effects Cu2+ CA 1 region hippocampal slices. Field excitatory postsynaptic potential (EPSP) slopes CA1 were unaffected by μM but depressed 10 (to 85%) 100 50%). A paired-pulse test revealed no difference facilitation presence or absence Cu2+, indicating a action....