A5084961934- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- Muscle activation and electromyography studies
- Botulinum Toxin and Related Neurological Disorders
- Neural and Behavioral Psychology Studies
- Glycogen Storage Diseases and Myoclonus
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Hemispheric Asymmetry in Neuroscience
- Ophthalmology and Eye Disorders
- Obsessive-Compulsive Spectrum Disorders
- Amyotrophic Lateral Sclerosis Research
- Visual perception and processing mechanisms
- Genetics and Neurodevelopmental Disorders
- Action Observation and Synchronization
- Autoimmune Neurological Disorders and Treatments
- Cerebral Palsy and Movement Disorders
- Migraine and Headache Studies
- Neuroscience and Neuropharmacology Research
University of Cagliari
2021-2025
National Hospital for Neurology and Neurosurgery
2016-2024
University College London
2015-2024
King's College London
2015-2024
Azienda Ospedaliero-Universitaria Cagliari
2021-2023
Agostino Gemelli University Polyclinic
2023
Sapienza University of Rome
2011-2020
University of Brescia
2019
Sobell House
2016-2018
Health First
2018
Backgroundthe use of combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) for the functional evaluation cerebral cortex in health disease is becoming increasingly common. However, there still some ambiguity regarding extent to which brain responses auditory somatosensory contribute TMS-evoked potential (TEP).Objective/Hypothesisto measure separately contribution caused by TMS, assess their TEP waveform, when stimulating motor (M1).Methods19 healthy volunteers...
Somatosensory temporal discrimination threshold (STDT) is defined as the shortest time interval necessary for a pair of tactile stimuli to be perceived separate. Although STDT altered in several neurological disorders, its neural bases are not entirely clear. We used continuous theta burst stimulation (cTBS) condition excitability primary somatosensory cortex healthy humans examine possible contribution STDT. Excitability was assessed using recovery cycle N20 component evoked potentials...
Abstract Interhemispheric interactions in stroke patients are frequently characterized by abnormalities, terms of balance and inhibition. Previous results showed an impressive variability, mostly given to the instability motor‐evoked potentials when evoked from affected hemisphere. We aim find reliable interhemispheric measures with a not‐evocable potential hemisphere, combining transcranial magnetic stimulation (TMS) electroencephalography. Ninteen (seven females; 61.26 ± 9.8 years) were...
In Alzheimer disease (AD) animal models, synaptic dysfunction has recently been linked to a disorder of high-frequency neuronal activity. patients, clear relation between AD and oscillatory activity remains elusive. Here, we attempt shed light on this by using novel approach combining transcranial magnetic stimulation electroencephalography (TMS-EEG) probe in specific hubs the frontoparietal network sample 60 mild-to-moderate patients.Sixty patients 21 age-matched healthy volunteers (HVs)...
Background The somatosensory temporal discrimination threshold (STDT) measures the ability to perceive two stimuli as being sequential. Precisely how single cerebral structures contribute in controlling STDT is partially known and no information available about whether can be modulated by plasticity-inducing protocols. Methodology/Principal Findings To investigate cortical cerebellar areas we used transcranial magnetic stimulation a neuronavigation system. We enrolled 18 healthy volunteers...
Continuous theta burst stimulation (cTBS) is a repetitive transcranial magnetic paradigm reported to decrease the excitability of stimulated cortical area and which thought reflect form inhibitory synaptic plasticity. However, since its introduction, effect cTBS has shown remarkable variability in effects, are often quantified by measuring amplitude motor evoked potentials (MEP). Part this inconsistency experimental results might be due an intrinsic TMS effects caused genetic or...
Somatosensory temporal discrimination threshold is often prolonged in patients with dystonia. Previous evidence suggested that this might be caused by impaired somatosensory processing the time domain. Here, we tested if other markers of reduced inhibition system also contribute to abnormal dystonia.Somatosensory was measured 19 isolated cervical dystonia and age-matched healthy controls. We evaluated using paired-pulse evoked potentials, spatial measuring potentials interaction between...
Qualitative smell/taste disorders (such as phantosmia, parosmia, phantogeusia, and parageusia) have not yet been fully characterized in patients who had COVID-19, whereas quantitative disturbances (i.e., reduction/loss of smell/taste) widely investigated.To simultaneously assess the presence both qualitative dysfunctions suffered from COVID-19.We enrolled 17 consecutive COVID-19 over last 6 months 21 healthy controls, matched for sex age. After a negative nasopharyngeal swab, Sniffin' Sticks...
Electroencephalographic (EEG) signals evoked by transcranial magnetic stimulation (TMS) are usually recorded with passive electrodes (PE). Active electrode (AE) systems have recently become widely available; compared to PE, they allow for easier preparation and a higher-quality signal, due the preamplification at stage, which reduces electrical line noise. The performance between AE PE can differ, especially fast EEG voltage changes, easily occur TMS-EEG; however, systematic comparison in...
When we look at our body parts, are immediately aware that they belong to us and rarely doubt about the integrity, continuity, sense of ownership body. Despite this certainty, immersive virtual reality (IVR) may lead a strong feeling embodiment over an artificial part seen from first-person perspective (1PP). Although such (FO) has been described in different situations, it is not yet understood how phenomenon generated neural level. To track real-time brain dynamics associated with FO,...
Motor impairment in Parkinson's disease (PD) reflects changes the basal ganglia-thalamocortical circuit converging on primary motor cortex (M1) and supplementary area (SMA). Previous studies assessed M1 excitability PD using transcranial magnetic stimulation (TMS)-evoked electromyographic activity. TMS-evoked electroencephalographic activity may unveil broader cortical network PD.The aim was to assess PD.We compared potentials (TEPs) from pre-SMA between 20 patients tested off medication 19...
ABSTRACT Background Apart from motor symptoms, multiple deficits of sensory processing have been demonstrated in dystonia. The most consistent behavioural measure this is abnormal somatosensory temporal discrimination threshold, which has recently associated with physiological measures reduced inhibition within the primary area. High‐frequency repetitive stimulation a patterned electric applied to skin through surface electrodes that reported shorten healthy subjects and increase resting...
The defining character of tics is that they can be transiently suppressed by volitional effort will, and at a behavioural level this has led to the concept result from failure inhibition. However, logic conflates mechanism responsible for production with used in suppressing them. Volitional inhibition motor output could increased prevent tic reaching threshold expression, although been extensively investigated conflicting results. Alternatively, automatic initial excitation striatal focus-a...