A5006583185- Pharmaceutical Practices and Patient Outcomes
- Hippo pathway signaling and YAP/TAZ
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Online Learning and Analytics
- Healthcare cost, quality, practices
- Sepsis Diagnosis and Treatment
- Educational Games and Gamification
- Adult and Continuing Education Topics
- Biomedical Ethics and Regulation
- Cognitive Functions and Memory
- Qualitative Research Methods and Ethics
- Innovations in Medical Education
- Corporate Governance and Law
- Peptidase Inhibition and Analysis
- Cellular Mechanics and Interactions
- Gut microbiota and health
- CAR-T cell therapy research
- Biochemical and Molecular Research
- Amino Acid Enzymes and Metabolism
- Community Development and Social Impact
- Interprofessional Education and Collaboration
- Climate Change and Health Impacts
University of Dundee
2024
Northumbria Healthcare NHS Foundation Trust
2023
University of Manchester
2021
Campbell University
2020
Boehringer Ingelheim (Germany)
2019
North Tyneside General Hospital
2014
Small-molecule degraders of disease-driving proteins offer a clinically proven modality with enhanced therapeutic efficacy and potential to tackle previously undrugged targets. Stable long-lived degrader-mediated ternary complexes drive fast profound target degradation; however, the mechanisms by which they affect ubiquitination remain elusive. Here, we show cryo-EM structures VHL Cullin 2 RING E3 ligase degrader MZ1 directing protein Brd4 BD2 toward UBE2R1-ubiquitin, Lys 456 at optimal...
Abstract Small molecule degraders of disease-driving proteins offer a clinically proven modality with enhanced therapeutic efficacy and the potential to tackle previously undrugged targets. Thermodynamically stable kinetically long-lived degrader-mediated ternary complexes can drive faster, more profound durable target degradation, however mechanistic features by which they impact on ubiquitination remain elusive. Here, we solve cryo-EM structures VHL Cullin 2 RING E3 ligase complexed...
Background Patient safety is a worldwide priority. Recommendations have been made that doctors, nurses and pharmacists could interact more effectively to improve patient outcomes, interprofessional education should be encouraged. In 2009, the North East Strategic Health Authority awarded Workforce Development Initiative funding Northumbria Healthcare National Service (NHS) Foundation Trust develop an undergraduate training activity in medication for medicine, pharmacy nursing students....
Integration of signalling downstream individual receptor tyrosine kinases (RTKs) is crucial to fine-tune cellular homeostasis during development and in pathological conditions, including breast cancer. However, how integration regulated whether the endocytic fate single receptors controls such remains poorly elucidated. Combining quantitative phosphoproteomics targeted assays, we generated a detailed picture recycling-dependent fibroblast growth factor (FGF) cancer cells, with focus on...
Microbial-dependent trimethylamine (TMA) generation from dietary precursors such as choline was recently linked to cardiovascular diseases (CVDs) well chronic kidney disease (CKD). Inhibition of TMA-generating enzymes in gut bacteria would be an innovative approach treat these diseases. The potential accurately quantify secreted TMA levels highlights the capacity mass spectrometry (MS) for tracking microbial TMA-lyase activity. However, high-throughput screening (HTS) by conventional MS...
Background: More people use more medications than ever before, which increases demands on the healthcare workforce to complete medication-related tasks. Nursing shortages are a challenge for many hospitals, therefore alternative roles needed create capacity within clinical teams meet demands. Pharmacy assistants work in stores and dispensaries but with additional training can be redeployed as Ward Medicines Assistants (WMAs) settings However, little is known about how much time WMAs spend...
SUMMARY Integration of signalling downstream individual receptor tyrosine kinases (RTKs) is crucial to fine tune cellular homeostasis during development and in pathological conditions, including breast cancer. However, how integration regulated whether the endocytic fate single receptors controls such remains poorly elucidated. Combining quantitative phosphoproteomics targeted assays, we generated a detailed picture recycling-dependent fibroblast growth factor (FGF) cancer cells, with focus...