Study Design Cross-sectional study. Background Findings of fat infiltration in cervical spine multifidus, as a sign degenerative morphometric changes due to whiplash injury, need be verified. Objectives To develop method using water/fat magnetic resonance imaging (MRI) investigate and cross-sectional area multifidus muscle individuals with whiplash-associated disorders (WADs) compared healthy controls. Methods Fat the muscles spanning C4 C7 segmental levels were investigated by manual...

New deep brain stimulation (DBS) electrode designs offer operation in voltage and current mode capability to steer the electric field (EF). The aim of study was compare EF distributions four DBS leads at equivalent amplitudes (3 V 3.4 mA). Finite element method (FEM) simulations (n = 38) around cylindrical contacts (leads 3389, 6148) or contact configurations 6180, SureStim1) were performed using homogeneous patient-specific (heterogeneous) tissue models. Steering effects 6180 SureStim1...

OBJECTIVE Structured physiotherapy has been suggested as treatment before well after surgery to improve clinical outcomes in patients with cervical radiculopathy (CR), but randomized trials inform evidence-based guidelines for the of CR are lacking. The aim this study was compare results structured postoperative combining neck-specific exercises a behavioral approach standard who had undergone disc disease at 6 months surgery. METHODS Patients and persistent were scheduled preoperatively (n...

Deep brain stimulation (DBS) requires precise and safe navigation to the chosen target. Optical measurements allow monitoring of gray-white tissue boundaries (total light intensity [TLI]) microvascular blood flow during stereotactic procedures.To establish link between TLI/blood anatomy along trajectories toward ventral intermediate nucleus (Vim) subthalamic (STN).Stereotactic laser Doppler were obtained with millimeter precision from cortex Vim (n = 13) STN 9). TLI created compared by...

<b><i>Background:</i></b> Deep brain stimulation (DBS) is a growing treatment modality, and most DBS systems require replacement of the implantable pulse generator (IPG) every few years. The literature regarding potential impact adverse events IPG on longevity treatments rather scarce. <b><i>Objective:</i></b> To investigate incidence events, including postoperative infections, associated with replacements in multicenter cohort....

Laser Doppler flowmetry (LDF) can be used to measure cerebral microcirculation in relation stereotactic deep brain stimulation (DBS) implantations.To investigate the and total light intensity (TLI) corresponding tissue grayness DBS target regions with high-resolution LDF recordings, define a resolution which enables detection of small vessels.Stereotactic measurements were made prior implantation 0.5-mm steps vicinity 4 targets (STN, GPi, Vim, Zi) along 20 trajectories. The Mann-Whitney U...

Unstable patients in the neurocritical care unit (NCCU) need repeated diagnostic imaging. Intrahospital transports of such is hazardous where even small changes physiology may lead to secondary brain injury. In this study we describe workflow, safety aspects and reflect on our initial experience close-to-bedside magnetic resonance (MR) imaging NCCU. A descriptive observational was conducted assess transportation method potential physiological associated with it. Eligible referred for MR...

Many patients with cervical disc disease require leave from work, due to long-lasting, complex symptoms, including chronic pain and reduced levels of physical psychological function. Surgery on a few segmental might be expected resolve disc-specific reduce neurological deficits, but not the non-specific neck frequent illness. No study has investigated whether post-surgery physiotherapy improve outcome surgery. The main purpose this was evaluate well-structured rehabilitation programme add...

The aim of the study was to investigate if laser Doppler perfusion monitoring (LDPM) can be used in order differentiate between gray and white matter what extent microvascular recorded deep brain structures during stereotactic neurosurgery. An optical probe constructed fit Leksell® Stereotactic System for measurements along trajectory targets (globus pallidus internus, subthalamic nucleus, zona incerta, thalamus) implantation stimulation leads (n = 22). total backscattered light intensity...

Diffuse reflectance spectroscopy as a method for improving intracerebral guidance during functional neurosurgery has been investigated. An optical probe was developed measurements stereotactic and in man. The aim of the study to investigate spectral differences between white grey matter targets. ten patients were recorded at incremental steps towards three different targets (STN, GPi Zi). spectra along trajectory sorted into or matter, based on preoperative MRI images shape intensity....

<b><i>Background:</i></b> Intracerebral hemorrhage (ICH) is the most feared complication in deep brain stimulation (DBS) surgery. The aim of study was to evaluate patient safety and outcome using laser Doppler flowmetry (LDF) as guidance tool during DBS implantations. <b><i>Methods:</i></b> An LDF probe adapted for stereotactic system used guide creation trajectory. microcirculation along 83 preplanned trajectories measured with surgery...

Deep brain stimulation (DBS) in zona incerta (Zi) is used for symptom alleviation essential tremor (ET). Zi positioned along the dentato-rubro-thalamic tract (DRT). Electric field simulations with finite element method (FEM) can be estimation of a volume where affects tissue by applying fixed isolevel (VDBS). This work aims to develop workflow combined patient-specific electric simulation and white matter tracing DRT, investigate influence on VDBS from different models, lead design modes....

Abstract Prognostic models play an important role in the clinical management of cervical radiculopathy (CR). No study has compared performance modern machine learning techniques, against more traditional stepwise regression when developing prognostic individuals with CR. We analysed a prospective cohort dataset 201 Four modelling techniques (stepwise regression, least absolute shrinkage and selection operator [LASSO], boosting, multivariate adaptive splines [MuARS]) were each used to form...

Abstract Background Objective Studies of cross-sectional area (CSA) (morphology) and muscle fat infiltration (MFI) (composition) in ventral neck muscles is scarce patients with chronic whiplash associated disorders (WAD), especially for men those severe WAD compared matched healthy controls. The aim was to compare CSA MFI sternocleidomastoid (SCM), longus capitis (LCA) colli (LCO) right-sided dominant moderate (Neck Disability Index: NDI < 40) or (NDI ≥ 40), age- sex-matched Methods...

Abstract Reports on neurological outcomes in patients with cervical radiculopathy (CR) undergoing surgery and postoperative rehabilitation are important to inform prognosis. This 2-year-follow-up of a randomized clinical trial aimed compare secondary between structured standard approach after for CR. A aim was increase knowledge about recovery impairments relation patient-reported neck disability. Neurological included assessment sensibility, motor function, arm reflexes the Spurling test....

Abstract Background The underlying pathophysiological mechanisms of chronic Whiplash Associated Disorders (WAD) are not fully understood. More knowledge morphology is needed to better understand the disorder, improve diagnostics and treatments. aim was investigate dorsal neck muscle volume (MV) fat infiltration (MFI) in relation self-reported disability among 30 participants with WAD grade II-III compared matched healthy controls. Methods MV MFI at spinal segments C4 through C7 both sexes...

Cross-sectional study.To investigate the factors associated with work ability in patients undergoing surgery for cervical radiculopathy.Surgery is a common treatment of radiculopathy people working age. However, few studies have investigated impact on these patients.Patients (n = 201) were recruited from spine centers Sweden to complete battery questionnaires and physical measures day before surgery. The associations between various individual, psychological, work-related self-reported by...

Abstract Objective Essential tremor is a common movement disorder with an unclear origin. Emerging evidence suggests the role of cerebellum and thalamus in pathophysiology. We examined two main neurotransmitters acting inhibitory (GABA+) excitatory (Glx) respectively, cerebellum, patients diagnosed severe essential tremor. Furthermore, we also investigated relationship between determined neurotransmitter concentrations severity patients. Methods Ten (prior to deep brain stimulation surgery)...

Abstract BACKGROUND We hypothesized that reduced cerebral blood flow (CBF) and/or energy metabolic disturbances exist in the tissue surrounding a surgically evacuated intracerebral hemorrhage (ICH). If present, such CBF impairments may contribute to ongoing injury and modest clinical efficacy of ICH surgery. OBJECTIVE To conduct an observational study state perihemorrhagic zone (PHZ) seemingly normal cortex (SNX) by microdialysis (MD) following surgical evacuation. METHODS evaluated 12...

Information about postoperative rehabilitation for cervical radiculopathy (CR) is scarce. The aim of this study was to investigate the additional benefits structured (SPT), which performed in all patients, compared with a pragmatic standard approach (SA), used as needed and patients sought physiotherapy on their own without referral, MRI evidence disc herniation concomitant clinical signs who underwent surgery CR.

Lead movement after deep brain stimulation may occur and influence the affected volume of stimulation. The aim study was to investigate differences in lead position between day surgery approximately 1 month postoperatively also simulate electric field (EF) around active contacts order impact displacement on volume.Twenty-three patients with disorders underwent (37 leads). Computed tomography at 2 time points were co-fused respectively stereotactic images Surgiplan. coordinates (x, y, z) tips...