A5058302559- Zebrafish Biomedical Research Applications
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Animal Behavior and Reproduction
- Fish Ecology and Management Studies
- Prenatal Substance Exposure Effects
- Neonatal and fetal brain pathology
- Hippo pathway signaling and YAP/TAZ
- Enzyme Catalysis and Immobilization
- Coffee research and impacts
- Biochemical Analysis and Sensing Techniques
- Amino Acid Enzymes and Metabolism
- Environmental Toxicology and Ecotoxicology
- Cholinesterase and Neurodegenerative Diseases
- Green IT and Sustainability
- PI3K/AKT/mTOR signaling in cancer
- Memory and Neural Mechanisms
- Calcium signaling and nucleotide metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Connexins and lens biology
- Child Abuse and Trauma
- Aquaculture Nutrition and Growth
- Neonatal Health and Biochemistry
- Pesticide and Herbicide Environmental Studies
- MicroRNA in disease regulation
Brazilian Institute of Environment and Renewable Natural Resources
2024
Universidade Federal do Rio Grande do Norte
2020-2022
Pontifícia Universidade Católica do Rio Grande do Sul
2011-2019
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
2012
Diflubenzuron (DFB) and pyriproxyfen (PPF) are larvicides used in crops to control insect plagues. However, these pesticides known impact non-target organisms like fish mammals. Here, we aimed at assessing the embryotoxicity of purified DFB, PPF, their mixtures a organism—zebrafish. Zebrafish embryos were exposed different concentrations for 120 h: 0.025, 0.125, 0.25, 1.25, 2.5, 10 mg/L PPF while 0.025 + DFB (Mix A), 0.125 B), 0.25 C) DFB. We observed mortality, teratogenicity,...
Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties. Thus, the modulation exerted by adenosine might be an effective tool to control seizures. In this study, we investigated effects drugs that are able modulate adenosinergic signaling on pentylenetetrazole (PTZ)-induced seizures in adult zebrafish. The A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) decreased latency onset tonic-clonic seizure stage. agonist...
Imbalances in glutamatergic signaling have been proposed as the cause of several neurological disturbances. The use MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, to mimic features these disorders is effective both mammals and fish. However, variability subunits comprising NMDA during development alters pharmacokinetic properties leads different responses this drug. Here, we evaluated locomotor response zebrafish MK-801 (1, 5, 20 μM) through (30 days postfertilization [dpf] 2...
During brain development, the electrical disturbance promoted by a seizure can have several consequences, because it disturb set of steps extremely regulated needed to correct maturation. Animal modeling is invaluable contribute mechanistic understanding punctual event, and those that triggered in an immature neural network could alter mature physiology. In present study we observed exposure kainic acid diluted directly water zebrafish decreased locomotor activity at 7 days...
Abstract Hyperargininemia is an inborn error of metabolism (IEM) characterized by tissue accumulation arginine (Arg). Mental retardation and other neurological features are common symptoms in hyperargininemic patients. Considering purinergic signaling has a crucial role from the early stages development underlying mechanisms this disease poorly established, we investigated effect Arg administration on locomotor activity, morphological alterations, extracellular nucleotide hydrolysis larvae...
Adverse experiences during childhood have been the focus of a series studies due to psychological damage observed in individuals who suffered abuse their youth. Studies with model animals that can mimic these observations significantly contribute understanding mechanisms behind this phenomenon. In our experiments, young zebrafish (20 dpf) were exposed aggressive alcoholized male adults for 30 min 10 days. At dpf, tested shoal formation, and at 60 locomotion aggression evaluated. Animals...