A5077068385- Complement system in diseases
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 and COVID-19 Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Platelet Disorders and Treatments
- Genomic variations and chromosomal abnormalities
- Transplantation: Methods and Outcomes
- Cancer Genomics and Diagnostics
- Renal Diseases and Glomerulopathies
- Intracranial Aneurysms: Treatment and Complications
- Renal Transplantation Outcomes and Treatments
- Diabetes Treatment and Management
- Bacterial Infections and Vaccines
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Erythrocyte Function and Pathophysiology
- Aortic aneurysm repair treatments
- Peptidase Inhibition and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuroscience and Neuropharmacology Research
- Trypanosoma species research and implications
- Prenatal Screening and Diagnostics
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
University of Leeds
2010-2023
St James's University Hospital
2011-2022
Urology of Virginia
2017
Contaminated Land: Applications in the Real Environments
2017
Institute of Molecular Medicine
2010
Albemarle (United States)
1960
The use of next-generation sequencing technologies to produce genomic copy number data has recently been described.Most approaches, however, reply on optimal starting DNA, and are therefore unsuitable for the analysis formalinfixed paraffin-embedded (FFPE) samples, which largely precludes many tumour series.We have sought challenge limits this technique with regards quality quantity material depth required.We confirm that can be used interrogate DNA from cell lines, fresh frozen FFPE samples...
Abstract Objectives A retrospective population‐based study to determine the incidence and prevalence of patients with rare blood disease paroxysmal nocturnal haemoglobinuria (PNH). Methods All were identified by flow cytometric detection cells deficient in glycosylphosphatidylinositol (GPI) linked proteins at a single diagnostic reference laboratory that serves Yorkshire based, Haematological Malignancy Research Network (HMRN) population 3.8 million. Results One hundred ninety‐seven...
Summary A retrospective analysis of presentation clinical, laboratory and immunophenotypic features 1 081 patients with paroxysmal nocturnal haemoglobinuria (PNH) clones [glycosylphosphatidylinositol (GPI)‐deficient blood cells] identified at our hospital by flow cytometry over the past 25 years was undertaken. Three distinct clusters were significant correlations between disease type PNH clone sizes evident. Smaller predominate in cytopenic myelodysplastic subtypes; large associated...
Abstract Advancing age and chronic health conditions, significant risk factors for severe COVID-19, are associated with a pro-inflammatory state, termed inflamm-aging. CXCR6 + T cells known to traffic the lung have been reported increase age. The ligand of CXCR6, CXCL16, is constitutively expressed in upregulated during inflammatory responses CXCR6/CXCL16 axis disease pneumonia. Genome-wide association studies also recently identified 3p21.31, encompassing gene, as susceptibility locus...
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder, characterized by complement-mediated intravascular hemolysis and thrombosis. The increased incidence of PNH-driven thrombosis still poorly understood, but unlike other thrombotic disorders, thought to largely occur through mechanisms. Treatment with C5 inhibitor, eculizumab, has been shown significantly reduce the number thromboembolic events in these patients. Based on previously described links between changes...
Background: In paroxysmal nocturnal haemoglobinuria (PNH), absence of glycosylphosphatidylinositol (GPI) anchors leads to loss the complement inhibitor, CD59, on PNH erythrocytes (E) causing complement-mediated intravascular haemolysis. Treatment with anti-C5 anitbody (eculizumab or ravulizumab) rescues PNH-E but another GPI-anchored regulator, CD55, accumulation C3 fragments E and extravascular haemolysis (EVH) due C3-driven erythrophagocytosis. Therefore, approximately 30% patients still...
Background: Clinical research in cerebrovascular diseases has become increasingly collaborative and relies on data collected at clinical care onset. Ways to efficiently systematically capture that are secure, adaptable, shareable is imperative. The Research Electronic Data Capture (REDCap) system, developed for an NIH-funded national consortium, holds great promise as a free, de-identifiable, modifiable, globally accessible web-based database. Objective: To develop REDCap-based system of...
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Background: The risk for intracranial (IA) and abdominal aortic aneurysms (AAA) is partially heritable, with evidence mounting in favor of shared genetic both. Methods: Brain Aortic Aneurysm Study (BAAS, NCT#17341) at University Virginia seeks to determine the coprevalence IA AAA recruiting patients presenting an aneurysm one site screening other. Participants undergo interview where clinical, demographic, radiographic data are collected. Recruitment ongoing, so preliminary demographic...
Background: Immunocompromised patients with bone marrow disorders may be vulnerable to more severe COVID-19 infection, less likely respond SARS-CoV-2 vaccinations or have increased adverse events. This real-world prospective observational study investigates outcomes of vaccination in aplastic anaemia (AA) and/or paroxysmal nocturnal haemoglobinuria (PNH).Methods: Serum spike-specific antibody responses were measured 171 and 45 healthy volunteers.Findings: After one vaccination, AA PNH had a...