A5098534423- Immunotherapy and Immune Responses
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
Universitätsmedizin Greifswald
2024-2025
COVID-19 vaccines are highly effective in inducing protective immunity. While the serum antibody response to vaccination has been studied depth, our knowledge of underlying plasmablast and memory B cell (Bmem) responses is still incomplete. Here, we determined a naïve population contrasted it with single influenza primed cohort. In addition, analyzed against four endemic human coronaviruses (HCoVs).
Antibodies play a pivotal role in the immune defense and long-term immunity. Yet, while several studies have highlighted persistence of antigen-specific antibody responses, it is unclear whether this stems from continuous production same clones or recurrent activation B cells generating new clones. To examine stability human repertoire, we monitored concentrations most abundant IgG1 plasma samples 11 healthy donors at nine sampling points over year. During year, each donor received three...