A5012385994- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diabetic Foot Ulcer Assessment and Management
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Thyroid Cancer Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Thyroid and Parathyroid Surgery
- Diabetes and associated disorders
- Mitochondrial Function and Pathology
- Lipid metabolism and disorders
- Diabetes Management and Research
- Vitamin D Research Studies
- Pituitary Gland Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Salivary Gland Disorders and Functions
- Drug-Induced Hepatotoxicity and Protection
- Retinal Diseases and Treatments
- Thyroid Disorders and Treatments
- Gestational Diabetes Research and Management
- Traditional Chinese Medicine Analysis
Fırat University
2017-2025
Background . The aim was to investigate the amounts of saliva and serum asprosin in order determine whether it is related obesity salivary glands synthesize or not. Methods A total 116 underweight, normal weight, overweight, obese (class I, class II, III) volunteers participated study. Saliva blood samples were collected simultaneously from participants. saliva, gland tissue supernatants, bloods determined by ELISA, whereas synthesis sites tissues immunohistochemically. Results amount lowest...
Pre-eclampsia is multisystem metabolic diseases, commonly accompanied by hypertension and proteinuria, which are among the important causes of maternal perinatal mortality morbidity worldwide. In a pre-eclampsia animal model study in last year, Elabela (ELA) infusion was reported to correct proteinuria normalise birth weights offspring. Therefore, our main goal this human compare ELA, apelin (APLN) nitric oxide (NO) levels blood pregnant women with severe their newborns' venous-arterial cord...
Metabolic syndrome (MetS) and obesity are important public health problems associated with adipose tissue mass. Asprosin, visfatin, subfatin new members of which fate in MetS has not been fully revealed yet. Thus, this study was to investigate the association between asprosin, subfatin, biochemical values, demographic data, body composition measurement values patients without obesity.Blood samples were taken from a total 90 people, including 31 obesity, 29 30 healthy (control). studied by...
Diabetes and associated complications still pose an important public health problem. Osteomyelitis as especially seen in patients with diabetes is increased rates of morbidity mortality. The present study aimed to investigate the clinical diagnostic significance inflammatory markers, including systemic immune-inflammation index (SII) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT) differentiate osteomyelitis cellulitis. included 96 (Group 1) 151 cellulitis...
Abstract Context The aims of the study are to compare characteristics subacute thyroiditis (SAT) related different etiologies, and identify predictors recurrence SAT incident hypothyroidism. Methods This nationwide, multicenter, retrospective cohort included 53 endocrinology centers in Turkey. participants were divided into either COVID-19–related (Cov-SAT), SARS-CoV-2 vaccine–related (Vac-SAT), or control (Cont-SAT) groups. Results Of 811 patients, 258 (31.8%) Vac-SAT group, 98 (12.1%)...
Asprosin and subfatin are recently discovered two new hormones of adipocyte origin that play a role in the regulation glucose metabolism. Polycystic ovary syndrome (PCOS) is gynaecological presenting with energy turbulence. The aim this study was to investigate whether asprosin PCOS disease. Thirty participants diagnosis thirty control group were included case-control study. Hormone profiles (subfatin, asprosin, insulin, prolactin, thyroid-stimulating hormone (TSH), oestradiol (E2),...
Background Giant cystic pheochromocytoma and giant adrenal myelolipoma are two highly uncommon masses. There difficulties in diagnosis management of both types (>20 cm) tumors. Case 1 A 56-year-old male patient applied with complaints headache high blood pressure. mass was palpated the left upper quadrant. The average 24-hour ambulatory pressure 146/93 mm Hg. Computed tomography revealed a huge measuring 22 × 17 cm. large renal parapelvic cyst 6 5.5 cm also observed. Urine...
ABSTRACT Objective This study aimed to evaluate the clinical characteristics, diagnostic approaches, and treatment outcomes of insulinoma patients from diverse regions across country. We conducted a retrospective analysis medical records 76 adult diagnosed with between 2018 2023 at 15 centres. Data collected included demographics, presenting symptoms, laboratory imaging results, surgical reports, pathology findings, follow‐up information. Design Multi‐centre study. Methods The revealed that...
Purpose: Adropin is discovered in recent years and it has been reported to be associated with glucose lipid metabolism . Our aim determine the relationship between blood serum adropin levels according glycosylated hemoglobin (HbA1c) concentration values patient groups diagnosed Type 2 Diabetes Mellitus control group. Methods: A total of 60 DM, 20 prediabetes for observation were recruited from Endocrinology clinic Fırat University Hospital. In addition, healthy subjects comparison as normal...
Purpose: Diabetic retinopathy (DRP) is the formation of edema and small vessels in retina due to high blood glucose levels. Asprosin a hormone that stimulates release from liver into circulation. Considering relationship between oxidative stress DRP, our study aimed determine levels markers 4-hydroxynonenal (4-HNE) 8-hydroxy-2′-deoxyguanosine (8-OHdG), as well asprosin, aqueous humor (Aq) patients with without DRP. Methods: Thirty single-eye DRP cataract (DRP + C), 30 diabetes mellitus (DM...
This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin‐3 (PTX‐3) in patients with infected diabetic foot ulcers (IDFU) as well assess association between PTX‐3 levels IDFU severity. included 60 (Group 1), 45 without DFU 2), healthy controls. Patients were divided into mild, moderate, severe subgroups based on classification clinical who underwent amputation also documented. Blood samples collected determine levels. controls, Group 1, 2 5.83 (3.41‐20) ng/mL,...
Chemerin and dermcidin, which have antimicrobial properties, are molecules that also related to insulin resistance inflammation.The aims were determine the amounts of chemerin dermcidin in milk blood mothers with gestational diabetes, compare without diabetes.This was a two-group nonrandomized longitudinal study convenience sampling diabetes (n = 27) 26). Human samples obtained from these during colostrum, transitional, mature periods. The amount measured by enzyme-linked immunosorbent...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
This study was planned to test whether follicular fluid (FF) levels of patatin-like phospholipase domain containing 3-gene (PNPLA3:adiponutrin), preptin, kisspeptin, and amylin change in polycystic ovarian syndrome (PCOS). A total 40 infertile volunteers undergoing IVF/ICSI were included the study. They divided into two groups as PCOS (n=20) control group without (n=20). The controls recruited from subjects with a poor response. participants matched according their body mass index (BMI)....
Objective: The incidence of thyroid cancer has been continuously increasing. main objective this study was to investigate irisin expression in various pathologies and compare these patterns with healthy tissues. Methods: groups consisted 20 cases each control tissue, Hashimoto's thyroiditis, papillary carcinoma, oncocytic follicular medullary anaplastic carcinoma. Irisin evaluated using immunohistochemistry. levels tissue supernatants were measured ELISA. Results: Patients HT showed...
Schizophrenia, particularly the form related to excessive dopamine (DA), is a chronic psychotic disorder affecting millions of people worldwide. Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophrenia occurrence. Therefore, current study aimed evaluate CA in serum patients with schizophrenia.The was conducted thirty-three age- gender-matched group thirty-one controls. were measured by using...
We investigated the presence of asprosin (ASP), betatrophin, elabela (ELA), glucagon and subfatin (SUB) in milk mothers with gestational diabetes mellitus (GDM) compared their levels blood levels. also whether these peptides are synthesized by breast. 12 volunteer GDM 14 pregnant non-GDM control mothers. The were measured using ELISA tissue localization was determined immunohistochemistry. Breast contains ASP, ELA, SUB. amount ranged from highest to lowest colostrum, transitional mature...
Obesity and hyperandrogenemia are known to have adverse effects on both developing follicle endometrium receptivity in polycystic ovarian syndrome (PCOS). Insulin resistance also contributes this dilemma as a cause or consequence leads worsening of the clinical picture. The difficulty obtaining pregnancy despite presence large number oocyte has concentrated our attention quality development. However, occurence subfertility caused us investigate different etiologic agents non-obese PCOS women...
The aim of this study was to investigate ELABELA (ELA) expression in benign and malignant renal tissues differences different nuclear grades clear cell carcinomas.Patients that underwent surgery due masses between the years 2007 2017 were used. Control (n = 23), papillary RCC (CcRCC) [Fuhrman Grade1 Fuhrman Grade2 Grade3 Grade4 23)], chromophobe 23) included study. Independent samples t-test used for 2-point intergroup assessments one-way analysis variance posthoctukey test others. Values P...