A5076492373- Parkinson's Disease Mechanisms and Treatments
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Birth, Development, and Health
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Pregnancy and Medication Impact
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Fault Detection and Control Systems
- Ginseng Biological Effects and Applications
- Adenosine and Purinergic Signaling
- Trace Elements in Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Advanced Control Systems Design
- RNA Research and Splicing
- Neurological diseases and metabolism
- Ziziphus Jujuba Studies and Applications
- Receptor Mechanisms and Signaling
University of South China
2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2015-2024
Shanghai University of Traditional Chinese Medicine
2015-2024
Harbin Medical University
2017-2024
Second Affiliated Hospital of Harbin Medical University
2017-2024
Shanghai University
2014
In recent decades, miRNA has been reported as a crucial modulator in some biology progressions. This work aims to assess the expression and role of miR-let-7a pyruvate kinase muscle isozyme M2 (PKM2) CC tissues cell lines. Here, we identified that was decreased tissues, SiHa HeLa cells (all P < 0.001), however, PKM2 increased these samples. Statistically, inversely associated with mRNA or protein (p = 0.013, p 0.015, respectively). In-vitro assays revealed ectopic repressed proliferation,...
The nucleus accumbens septi (NAcc) is a key brain region in the rewarding effects of addictive drugs such as opiates and ethanol. We recently showed that opiate peptides reduced both excitatory inhibitory postsynaptic potentials (EPSPs IPSPs) NAcc neurons slice preparation, with naloxone (Nal) reversal (Yuan et al., 1992). To test other drugs, we used intracellular recording this rat preparation to investigate ethanol actions on neuronal properties. Ethanol 22 66 mM had little reproducible...
Abstract Ferroptosis is an iron-dependent cell death form characterized by reactive oxygen species (ROS) overgeneration and lipid peroxidation. Myricetin, a flavonoid that exists in numerous plants, exhibits potent antioxidant capacity. Given iron accumulation ROS-provoked dopaminergic neuron are the two main pathological hallmarks of Parkinson’s disease (PD), we aimed to investigate whether myricetin decreases neuronal through suppressing ferroptosis. The PD models were established...
Abstract Vitamin D insufficiency or deficiency during pregnancy has been associated with an increased risk of preeclampsia. Increased placental cyclooxygenase-2 (COX-2) activity was proposed to contribute the inflammatory response in This study investigate if vitamin can benefit preeclampsia by inhibiting COX-2 expression. Placenta tissues were obtained from 40 pregnant women (23 normotensive and 17 preeclampsia). miR-26b-5p expression assessed quantitative PCR. receptor (VDR) determined...
Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) demonstrated play an important roles a many cancers, detailed function mechanism has not been reported OC. We integrated multiple kinds bioinformatics approaches experiments validated method to evaluate functions FAM83H-AS1 Some differential expressed lncRNAs...
Abstract Autonomic symptoms (AS) are critical in Parkinson’s disease (PD). We aimed to determine the relative significance of clinical factors allowing predictions about incidence AS, and examine AS profiles among PD patients by motor subtype its relation AS. The cross-sectional data a multicentre sample, including 714 194 healthy controls from Progression Marker Initiative study Pingchan granule were analyzed, stratified subtypes [postural instability gait disturbances (PIGD), tremor...
Abstract Vitamin D insufficiency/deficiency has been linked to an increased risk of preeclampsia. Impaired placental amino acid transport is suggested contribute abnormal fetal intrauterine growth in pregnancies complicated by However, if vitamin D-regulated transporter involved the pathophysiologic mechanism preeclampsia not clarified yet. The aberrant expression key isoform L-type LAT1 was determined western blot and immunohistochemistry placenta from normotensive preeclamptic pregnancies....
This study was performed to observe the effects of Zishenpingchan granule on neurobehavioral manifestations and activity gene expression striatal dopamine D1 D2 receptors rats with levodopa-induced dyskinesias (LID). We established normal control group, LID model TCM intervention group. Each group received treatment for 4 weeks. Artificial neural network (ANN) applied excavate main factor influencing variation in LID. The results showed that overactivation direct pathway mediated by receptor...
Background The association between body mass index (BMI) and rapid eye-movement (REM) sleep-related behavioral disorder (RBD) in Parkinson’s disease (PD) remains unknown. Our study was to investigate the of BMI with RBD PD patients. Methods In this cross-sectional study, a total 1,115 participants were enrolled from Progression Markers Initiative (PPMI) database. calculated as weight divided by height squared. defined questionnaire (RBDSQ) score cutoff 5 or more assessed. Univariable...
To evaluate the clinical efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency heart and gallbladder.We conducted a double-blind, randomized, controlled trial involving 100 patients gallbladder. Patients were randomly divided into treatment group (n = 50) control according to random number table. The was given decoction, while treated Suanzaoren decoction. pharmacological lasted for 8 weeks. assessed by using Spiegel scale, Pittsburgh sleep quality index (PSQ)...
To investigate the regulatory mechanism of c-Jun N-terminal protein kinase (JNK) signaling pathway in substantia nigra (SN) dopaminergic neurons inflammation and apoptosis, neuroprotective effect Zishenpingchan granules mice with Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PD model were established intraperitoneally injecting MPTP. Sixty divided into a group, Traditional Chinese Medicine (TCM) group control group. The TCM administered 7 days...
Abstract Background The association between body mass index (BMI) and rapid eye-movement (REM) sleep-related behavioral disorder (RBD) in Parkinson’s disease (PD) remains unknown. Our study was to investigate the of BMI with RBD PD patients. Methods In this cross-sectional study, a total 1115 participants were enrolled from Parkinson's Progression Markers Initiative (PPMI) database. calculated as weight divided by height squared. defined questionnaire (RBDSQ) score cutoff 5 or more assessed...
MicroRNAs (miRNAs) have key roles in the pathological processes of neuropathic pain. Here, our aim was to elucidate function miR-200a-3p as well its related regulatory mechanism An animal model pain established by chronic constriction injury (CCI) induction. The knockdown experiments are performed injecting a lentiviral construct intrathecally. MiR-200a-3p and bromodomain-containing protein 3 (BRD3) expression rat spinal cord determined using RT-qPCR. mechanical, thermal, cold responses...
Abstract Background Parkinson’s disease (PD) is a progressive neurodegenerative common in aged populations. Classified by Hoehn & Yahr stages, patients are often divided into mild/early stage, moderate/middle and advanced/late stage. With progression, PD shows high heterogeneity each Based on traditional Chinese medicine (TCM) syndrome differentiation theory our previous works, we found that during the early main Yin deficiency of liver kidney; moderate syndromes phlegm heat wind...
The objective of this study was to investigate the role endothelial nitric oxide synthase (eNOS), matrix metalloproteinases (MMP)-9, and Bcl2-associated oncogene 6 (BAG-6) gene polymorphisms, as well combined single nucleotide polymorphisms (SNPs) in hypertensive disorders pregnancy (HDP) patients. This case–control consisted women with 326 HDP 312 healthy pregnant controls. Multiplex PCR next-generation sequencing method used for determination polymorphisms. Nine SNPs were analyzed, we...
Abstract Background Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) demonstrated play an important roles a many cancers, detailed function mechanism has not been reported OC. Methods We integrated multiple kinds bioinformatics approaches experiments validated method to evaluate functions FAM83H-AS1 Results...