A5008140267- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Peptidase Inhibition and Analysis
- Radiation Dose and Imaging
- Prostate Cancer Treatment and Research
- Advanced MRI Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Bladder and Urothelial Cancer Treatments
- Esophageal Cancer Research and Treatment
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Atomic and Subatomic Physics Research
- Endometrial and Cervical Cancer Treatments
- Esophageal and GI Pathology
- Head and Neck Cancer Studies
- Ultrasound and Hyperthermia Applications
- Ovarian cancer diagnosis and treatment
University Medical Center Utrecht
2018-2022
Heidelberg University
2021
University Hospital Heidelberg
2021
The Christie NHS Foundation Trust
2018
Oklahoma State University Center for Health Sciences
2016
Online adaptive radiotherapy using the 1.5 Tesla MR-linac is feasible for SBRT (5 × 7 Gy) of pelvic lymph node oligometastases. The workflow allows full online planning based on daily anatomy. Session duration less than 60 min. Quality assurance tests, including independent 3D dose calculations and film measurements were passed.
High resolution 7T MRI is increasingly used to investigate hippocampal subfields in vivo, but most studies rely on manual segmentation which labor intensive. We aimed evaluate an automated technique segment and the entorhinal cortex at MRI.The cornu ammonis (CA)1, CA2, CA3, dentate gyrus, subiculum, were manually segmented, covering of long axis hippocampus 0.70-mm(3) T2-weighted images 26 participants (59 ± 9 years, 46% men). The approach was applied evaluated by using leave-one-out...
Patients were treated at our institute for single and multiple lymph node oligometastases on the 1.5T MR-linac since August 2018. The superior soft-tissue contrast additional software features of compared to CBCT-linacs allow online adaptive treatment planning. purpose this study was perform a target coverage dose criteria based evaluation clinically delivered radiotherapy with conventional CBCT-linac treatment.Patient data used from 14 patients 6 (2-3) metastases. All prescribed 5 × 7 Gy...
Background and purposeRecent studies have shown that the use of magnetic resonance (MR) guided online plan adaptation yields beneficial dosimetric values reduces unplanned violations dose constraints for stereotactic body radiation therapy (SBRT) lymph node oligometastases. The purpose this R-IDEAL stage 0 study was to determine optimal approach MR-guided SBRT treatment oligometastases.Materials MethodsUsing pre-treatment computed tomography (CT) repeated MR data from five patients with in...
Purpose: Online 1.5T MR imaging on the MR-linac gives better target visualization compared to CBCT and facilitates online adaptive treatment strategies including daily replanning. In this simulation study, dosimetric impact of replanning was investigated for SBRT lymph node oligometastases as a method correcting inter-fraction anatomical changes.Methods: Pre-treatment plans were created 17 pelvic para-aortic nodes, with 3 8 mm PTV margins reflecting our clinical practice nodes good poor...
Vacuum cushion immobilization is commonly used during stereotactic body radiotherapy (SBRT) to reduce intrafraction motion. We investigated target and bony anatomy motion (translations rotations) online adaptive SBRT on an MR-linac for pelvic/para-aortic lymph node metastases with without vacuum cushion.Thirty-nine patients underwent 5x7 Gy a 1.5T MR-linac, 19 were treated cushion, 1 patient sequentially without. Intrafraction was calculated nodes (GTVs) nearby anatomy, three time intervals...
At our department, MR-guided stereotactic body radiation therapy (SBRT) using the 1.5T MR-linac system (Unity, Elekta AB, Stockholm, Sweden) has been initiated for patients with lymph node oligometastases. Superior soft tissue contrast and possibility online plan adaptation on Unity may allow hypofractionated treatment. The purpose of this study was to investigate dosimetric feasibility compare quality different schemes.Data used from 12 single oligometastases (10 pelvic, 2 para-aortic),...
Whole bladder radiotherapy is challenging due to inter- and intrafraction size shape changes. To account for these changes, currently a Library of Plans (LoP) technique often applied, but daily adaptive also increasingly becoming available. The aim this study was compare LoP with two magnetic resonance imaging guided (MRgRT) strategies by comparing target coverage volume healthy tissue inside the planning (PTV) whole treatments.Data from 25 MRgRT lymph node oligometastases treatments (125...
Magnetic resonance (MR)-linac delivery is expected to improve organ at risk (OAR) sparing. In this study, OAR doses were compared for online adaptive MR-linac treatments and conventional cone beam computed tomography (CBCT)-linac radiotherapy, taking into account differences in clinical workflows, especially longer session times delivery.For 25 patients with pelvic/abdominal lymph node oligometastases, calculated pre-treatment daily optimized 1.5 T treatment plans (5 × 7 Gy) simulated...
Prostate cancer oligometastatic disease can be treated using stereotactic body radiotherapy (SBRT) in order to postpone start of systemic treatments such as androgen deprivation therapy (ADT). 68Ga-PSMA-PET/CT imaging allows for diagnosis oligometastases at lower PSA values. We analysed a cohort patients with prostate lymph node detected on PSMA-PET/CT.Ninety metachronous received SBRT 1-3 metastases diagnosed 68Ga-PSMA-PET/CT. The primary end point was progression free survival (PFS),...
Apparent diffusion coefficient (ADC) reflects micro-enviromental changes and therefore might be useful in predicting recurrence prior to brachytherapy. The purpose of this study is evaluate change ADC the primary tumour pathologic lymph nodes during treatment correlate with clinical outcome.Twenty patients were included who received chemoradiation for locally advanced cervical cancer between July 2016 November 2017. All underwent magnetic resonance imaging (MRI) treatment, three MRIs weeks...
Purpose or ObjectivePalliative radiotherapy for bone metastases is offered in patients with a life expectancy of at least 4 weeks and provides improved pain control 60%.Short time to response (median 2-3 weeks) healthrelated quality (HRQoL) responders has increased use those expected short survival.In general, HRQoL deteriorates towards death.It not clear, if this period, the association between maintained.This study investigated relationships survival, QoL outcomes. Material MethodsWeekly...
Purpose or ObjectiveOn the MR-Linac system (Elekta Unity, Elekta AB, Stockholm, Sweden) any change in patient set-up will be corrected for using a 'virtual couch shift", where defined MLC aperture shifts, rather than couch.Additionally, segment weights and shapes may reoptimised to account daily anatomical changes.This study investigates swift, dosimetrically acceptable processes re-optimisation of treatment plans setup rectum volume changes prostate patients. Material Methods