A5017697038- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Crystallography and molecular interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Sulfur-Based Synthesis Techniques
- Synthesis and Reactivity of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Synthesis of Indole Derivatives
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Nanomaterials for catalytic reactions
- Click Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Synthetic Organic Chemistry Methods
- HIV/AIDS drug development and treatment
Indian Institute of Technology Bombay
2022
Institute of Chemical Technology
2015-2020
University of Mumbai
2016-2020
A broadly applicable catalyst system consisting of water-soluble Pd–imidate complexes has been enployed for the Suzuki–Miyaura cross-coupling four different nucleosides in water under mild conditions. The efficient nature also allowed its application developing a microwave-assisted protocol with purpose expediting catalytic reaction. Preliminary mechanistic studies, assisted by poison tests and stoichiometric performed using an electrospray ionization spectrometer, revealed possible presence...
Two new water-soluble phosphatriazene as versatile ligands for catalyzing Suzuki–Miyaura reactions of purines and pyrimidines in neat water with the possibility recycling. Copper-free Sonogashira Heck reaction were also made possible.
Pd–imidate complexes as recyclable catalysts for Heck alkenylation of pyrimidine nucleosides. have been employed efficient the unprotected 5-iodo-2′-deoxyuridine in acetonitrile.
Abstract The synthesis of a highly efficient, water soluble [Pd(Sacc) 2 (TPA) ] complex for C‐C bond formation is described. Additionally, application the Suzuki‐Miyaura arylation all four nucleosides (5‐iodo‐2′‐deoxyuridine [5‐IdU], 5‐iodo‐2′‐deoxycytidine [5‐IdC], 8‐bromo‐2′‐deoxyadenosine, and 8‐bromo‐2′‐deoxyguanosine) with various aryl/heteroaryl boronic acids in plain under milder conditions demonstrated. © 2016 by John Wiley & Sons, Inc.
The improvement in fluorescence properties of 2′-deoxyuridine was made possible by the introduction (hetero)aromatic moieties at C–5 position uridine with alkenyl/phenyl/styryl linkers to create a library useful fluorescent nucleosides.
Abstract A method for the stereoselective synthesis of substituted tetrahydrofurans (THFs), tetrahydropyrans (THPs), as well chromans using intermolecular hydrogen atom transfer (HAT) followed by intramolecular radical cyclization alkenyl vinylogous carbonates is described. This Fe(acac) 3 ‐catalyzed reaction uses PhSiH H‐source and works under ambient conditions in HFIP/ethylene glycol (5:1 mixture) solvent. The methodology developed has broad substrate scope amenable to gram‐scale...
In the asymmetric unit, equalling unit cell (triclinic, P 1, Z = 1), two molecules of title compound, 8-(4-methylphenyl)-D-2′-deoxyadenosine, C 17 H 19 N 5 O 3 , are present, with distinct conformations sugar moieties, together one solvent water molecule. All three ribose atoms involved in hydrogen bonding and crystal packing is largely determined by hydrogen-bonding or hydrogen–heteroatom interactions (O—H...O, O—H...N, N—H...O, C—H...O C—H...N) independent molecule directly linked to four...
Abstract The new approach is used for the highly efficient scale‐up synthesis of HSV‐1 inhibitor Brivudine (BVDU) (IV).