A5088606108- Synthesis and biological activity
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Synthesis of heterocyclic compounds
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Natural product bioactivities and synthesis
- Piperaceae Chemical and Biological Studies
- Natural Antidiabetic Agents Studies
- Synthesis and Reactions of Organic Compounds
- Eicosanoids and Hypertension Pharmacology
- Crystallography and molecular interactions
- Adenosine and Purinergic Signaling
- Medicinal Plants and Neuroprotection
- Chemical synthesis and pharmacological studies
- Phytochemistry and Biological Activities
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Nuclear Receptors and Signaling
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Phytochemicals and Medicinal Plants
Jamia Hamdard
2013-2020
Hamdard University
2013-2016
Piperine is an alkaloid responsible for the pungency of black pepper. In this study, piperine isolated from Piper nigrum L. was hydrolyzed under basic condition to obtain piperic acid and used as precursor carry out synthesis twenty derivatives containing benzothiazole moiety. All were evaluated their antidiabetic potential by OGT test followed assessment active on STZ-induced diabetic model. It observed that nine novel analogues (5b, 6a-h), showed significantly higher activity in comparison...
Two new triterpenoids characterised as 30-normethyl fernen-22-one (capillirone, 1) and hopan-3β-ol (capillirol B, 2), along with two known triterpenoids, 4-α-hydroxyfilican-3-one 3-β,4-α-dihydroxyfilicane, have been isolated from the ethanolic extract of fronds Adiantum capillus-veneris Linn. (Adiantaceae). Compounds 1 3 showed significant anti-inflammatory activity 33.07% (p < 0.01) 42.30% 0.001) inhibition compared to indomethacin that exhibited 60.00% after h in carrageenan-induced hind...
A library of synthesized conjugates phenoxy acetic acid and thiazolidinedione 5a – m showed potent peroxisome proliferator activated receptor‐γ (PPAR‐γ) transactivation as well significant blood glucose lowering effect comparable to the standard drugs pioglitazone rosiglitazone. Most compounds higher docking scores than drug rosiglitazone in molecular study. Compounds 5l 5m exhibited PPAR‐γ 54.21 55.41%, respectively, comparison rosiglitazone, which 65.94 82.21% activation, respectively....
A focused library of novel benzyl pyrrolones has been synthesized and their in silico molecular docking studies carried out against TNF-α target. Among all the docked molecules, compound 3f showed best glide score -6.89. All compounds were evaluated for vivo anti-inflammatory activity by carrageenan-induced paw edema model. Compounds showing significant further tested vitro TNF α expression. 3b 2b found to show inhibition 76.22% 71.47%, respectively after 5 h comparison with standard drug...
Twenty-eight benzothiazole based sulfonylureas/sulfonylthioureas were synthesized and found to be effective against diabetes as PPAR-γ agonists.
The present study aimed to investigate the anti-inflammatory activity of ethanolic extract aerial parts <i>Trichosanthes dioica</i> and its successive fractions. effect on oxidative stress involved in pathogenesis inflammation was evaluated. fractions were administered at a dose 150 300 mg/kg b. w. for testing their by carrageenan-induced edema model. results showed that ethyl acetate fraction exhibited significant potency against inflammation. Pertaining mechanistic insight, might be...
Out of 32 novel 2-imino-4-thiazolidinones, compounds<bold>3f</bold>&<bold>3g</bold>showed potent anti-inflammatory activity without causing any damage to the stomach.