A5100625400- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Animal Genetics and Reproduction
- Chromosomal and Genetic Variations
- Stock Market Forecasting Methods
- Financial Markets and Investment Strategies
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Molecular Biology Techniques and Applications
- Computational Drug Discovery Methods
- Connexins and lens biology
- Research, Science, and Academia
- RNA regulation and disease
- Polysaccharides Composition and Applications
- Wnt/β-catenin signaling in development and cancer
- Microencapsulation and Drying Processes
- Cancer-related gene regulation
- Renal and related cancers
- Pain Mechanisms and Treatments
- Enzyme function and inhibition
- Signaling Pathways in Disease
- Synthesis and biological activity
- Extracellular vesicles in disease
- Trigeminal Neuralgia and Treatments
First Affiliated Hospital of Xiamen University
2023-2025
Cedars-Sinai Medical Center
2024
Xiamen University
2024
Jinan University
2004-2021
Jiangxi Normal University
2021
Eastern Virginia Medical School
2016
Peking University
2013-2014
University of California, Los Angeles
2013
Customized TALENs and Cas9/gRNAs have been used for targeted mutagenesis in zebrafish to induce indels into protein-coding genes. However, are usually not sufficient disrupt the function of non-coding genes, gene clusters or regulatory sequences, whereas large genomic deletions inversions more desirable this purpose. By injecting two pairs TALEN mRNAs gRNAs together with Cas9 mRNA targeting distal DNA sites same chromosome, we obtained predictable sizes ranging from several hundred bases...
Abstract We report that Cas9/gRNA mediates efficient genetic modifications in Drosophila. Through targeting seven loci, we achieved a germline efficiency of up to 100%. Genes both heterochromatin and euchromatin can be modified efficiently. Thus the system is an attractive tool for rapid disruption essentially any gene
The steps governing healing with or without fibrosis within the same microenvironment are unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate SOX9 for self-restoration. Using a multimodal approach head-to-head comparison of injury-induced lineages, we identified dynamic switch in repairing epithelia. Lineages that regenerated epithelia silenced and healed (SOX9
This study evaluated the efficacy and safety of stellate ganglion block (SGB) combined with trioxygen autologous blood retransfusion therapy (TABRT) in treating postherpetic neuralgia (PHN) head face elderly patients. A total 190 patients (aged ≥ 60 years) PHN were randomly assigned to receive either drug treatment alone (Group D, n = 40), SGB DS, 52), TABRT DT, 53), or DST, 45). Key outcomes included pain visual analogue scale (VAS) scores anxiety levels at baseline, 7 days, 15 days...
ABSTRACT Vitamin D3 and its metabolites calcifediol have been recommended as effective drugs for novel coronavirus disease 2019 (COVID‐19) therapy in many studies, since the outbreak of this global dramatic pandemic. In study, we made a striking discovery that Calcifediol demonstrates robust inhibitive effect on papain‐like cysteine protease (PLpro), critical proteolytic enzyme severe acute respiratory syndrome coronavirus‐2(SARS‐COV‐2), through small‐scale FRET‐based screening experiment....
Abstract Background: Exosomes are a subset of extracellular vesicles, considered packets information derivative mother cell carrying molecular signature that is used for intercellular communication. This type communication particularly important in the maintenance homeostasis viral infection. It possible this can be exploited as predictive biomarker disease progression, treatment response, metastatic potential. To date, there have been no published studies evaluating exosomes HPV+ OPSCC. We...