A5060953610- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Cancer Treatment and Pharmacology
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Advances in Oncology and Radiotherapy
- HER2/EGFR in Cancer Research
- Male Breast Health Studies
- Cancer Risks and Factors
- Clinical practice guidelines implementation
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- COVID-19 and healthcare impacts
- Surgical Simulation and Training
- Cervical Cancer and HPV Research
- Estrogen and related hormone effects
- AI in cancer detection
- Healthcare Systems and Technology
- Reconstructive Facial Surgery Techniques
St Helens and Knowsley Teaching Hospitals NHS Trust
2012-2024
Whiston Hospital
1994-2022
St Helens Hospital
2019
Weatherford College
2005
University of Liverpool
1996-1997
Aintree University Hospital
1996
St Mary's Hospital
1995
University of Oxford
1995
BackgroundUse of biological or synthetic mesh might improve outcomes immediate implant-based breast reconstruction—breast reconstruction with implants expanders at the time mastectomy—but there is a lack high-quality evidence to support safety effectiveness technique. We aimed establish short-term performed and without mesh, inform feasibility undertaking future randomised clinical trial comparing different techniques.MethodsIn this prospective, multicentre cohort study, we consecutively...
The quality of surgical research, and particularly the reluctance surgeons to perform randomized controlled trials, has been criticized. proportion treatments supported by satisfactory scientific evidence not evaluated previously. A 1-month prospective audit was performed 100 inpatients admitted under two consultants in a general surgical/vascular unit at an urban teaching hospital; main illness interventions were agreed through group discussions each case. literature concerning efficacy...
A 3-year prospective study of the learning curve for D2 gastrectomy was carried out by one surgeon beginning to perform operation independently after intensive specialist training. Some 38 patients were treated; there four postoperative deaths and 22 had complications. Postoperative morbidity decreased significantly with time (rS = -0.38, P 0.02, 95 per cent confidence interval -0.62 -0.07). The physiological component POSSUM (Physiological Operative Severity Score enUmeration Mortality...
Aim: To determine the outcome of management symptomatic gallstone disease (GSD) in patients aged 80 years or more.Patients and Methods: A retrospective review 79 admitted to 2 district general hospitals with GSD over a 1-year period was undertaken.Patients were grouped according method management: non-operative, ERCP, cholecystectomy.POSSUM scores for ERCP cholecystectomy groups calculated observed, predicted compared.Results: Obstructive jaundice biliary colic most common presenting...
O nly a few years ago, surgeons were rarely asked to excise non-palpable breast lesions detected following imaging.Our practice has significantly changed, and almost 30% of surgically removed are non-palpable. 1o define the exact area be excised, whilst avoiding excessive removal healthy tissue, ROLL technique was developed in 1996 at European Institute Oncology, Milan. 2,3echnical details have previously been described 4-6 results reported.The advantages this can summarised as: (i) precise...
Outcomes from breast cancer for women in the UK have improved significantly over recent decades. These gains are largely attributable to a combination of earlier diagnosis and access treatments delivered patients by National Health Service irrespective cost. Ethnic minority groups make up almost fifteen percent population there is concern however that these may poorer outcomes disease. In this short report we seek summarise what current evidence tells us about patterns incidence ethnic order...
Chemotherapy in the neo adjuvant setting has allowed downsizing of breast tumours thus allowing patients to benefit from conservation surgery. The effect neoadjuvant chemotherapy (NAC) also been observed axilla but most units are still treating with axillary lymph node dissection (ALND).A prospective database cancer receiving NAC between 2007 and 2016 at a single unit was reviewed. management outcomes studied.165 received NAC, 123 (74.5%) were clinically/radiologically positive 42 negative....
Background: Breast pain accounts for 20–40% of new referrals to breast units in the UK and these patients have a very low risk cancer. Patients previously been assessed resource-intensive, cancer-exclusion, one stop clinics, which are now failing meet government targets due excessive demand. increasingly piloting Pain-only Pathways (BPP) assess patients, there is no consensus optimal pathway. The aim this prospective multicentre study safety patient satisfaction different BPPs inform future...
Breast cancer (BC) is the leading cause of female deaths in Africa, and Zimbabwe, >80% present with advanced disease. A Needs Project (NP) was carried out to determine key factors responsible for delayed diagnosis poor BC outcomes investigate possible solutions 6 rural urban districts Matabeleland South Bulawayo Metropolitan Provinces.A mixed method approach used collect data 2 phases. Phase 1: an exploration >50 professional stakeholders patient representatives. 2: (i) Quantitative arm;...
Chromosome 17 alterations affect the assessment of HER2 gene amplification in breast cancer (BC), but its clinical significance remains unclear. This study aimed to identify prevalence centromere enumeration probe (CEP17) alterations, and correlation with response neoadjuvant therapy (NAT) BC patients human epidermal growth factor receptor 2 (HER2) immunohistochemistry-equivocal score.A large cohort (n = 6049) immunohistochemistry score 2+ florescent in-situ hybridisation (FISH) results was...