A5019941262- Oxidative Organic Chemistry Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Carbohydrate Chemistry and Synthesis
- Enzyme Production and Characterization
- Microbial Natural Products and Biosynthesis
- Microbial Metabolites in Food Biotechnology
- Marine Sponges and Natural Products
- Neuroblastoma Research and Treatments
- Tuberculosis Research and Epidemiology
- Axial and Atropisomeric Chirality Synthesis
- Bioactive Natural Diterpenoids Research
- Plant-based Medicinal Research
- Fungal Biology and Applications
- ATP Synthase and ATPases Research
- Antibiotic Resistance in Bacteria
- Crystallography and molecular interactions
- Mycorrhizal Fungi and Plant Interactions
- Polysaccharides and Plant Cell Walls
- Alkaloids: synthesis and pharmacology
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS drug development and treatment
- Asymmetric Synthesis and Catalysis
University of California, Irvine
2015-2021
Entasis Therapeutics (United States)
2020
Davidson College
2020
National Center for Advancing Translational Sciences
2017
National Institutes of Health
2017
University of California, Berkeley
2016
Hamilton College
2014
We report the discovery and medicinal chemistry optimization of a novel series pyrazole-based inhibitors human lactate dehydrogenase (LDH). Utilization quantitative high-throughput screening paradigm facilitated hit identification, while structure-based design multiparameter enabled development compounds with potent enzymatic cell-based inhibition LDH activity. Lead such as 63 exhibit low nM both LDHA LDHB, submicromolar production, glycolysis in MiaPaCa2 pancreatic cancer A673 sarcoma...
A synthetic approach to paxilline indole diterpenes is described. The route the pentacyclic core relies on a new regioselective alkenylation of ketones and tandem radical addition–aldol reaction sequence access vicinal quaternary stereocenters. Emindole SB, simplest member family, synthesized in 11 steps from commercially available material demonstrate application this approach.
Ascospores of Neosartorya, Byssochlamys and Talaromyces can be regarded as the most stress-resistant eukaryotic cells. They survive exposure at temperatures high 85°C for 100 min or more. Neosartorya fischeri ascospores are more viscous resistant to combined stress heat desiccation than macrosporus which contain predominantly trehalose. These trehalose-based oligosaccharides (TOS) that novel compatible solutes, accumulated levels. compounds also found in other members genus some genera...
Paxilline indole diterpenes have been a subject of scientific inquiry for over 30 years due to their diverse biological activities and unique structural features. These efforts resulted in multitude synthetic approaches dozen completed synthesis. Here, we discuss our contributions this area that culminated an 11-step synthesis (±)-emindole SB.
Three complex α-1,6-linked trehalose-based oligosaccharides with unique preservation properties, isobemisiose, neosartose, and fischerose, were recently identified from the extreme stress-tolerant ascospores of Neosartorya fischeri. Herein, we report first concise, scalable, iterative chemical synthesis these a differentially protected thioglycoside donor selectively protected, asymmetric trehalose acceptor. This work constitutes an improved is also reported tetrasaccharide, pentasaccharide,...