A5076579370- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Nutrition, Genetics, and Disease
- Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Vascular Tumors and Angiosarcomas
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Global Cancer Incidence and Screening
- Plant biochemistry and biosynthesis
- Health disparities and outcomes
- RNA and protein synthesis mechanisms
- Colorectal and Anal Carcinomas
- Protein Kinase Regulation and GTPase Signaling
- Tumors and Oncological Cases
- Polyomavirus and related diseases
- Biological Research and Disease Studies
- Transplantation: Methods and Outcomes
Northwestern University
2022-2025
University of Pennsylvania
2023-2024
Lund University
2006-2008
University of Michigan
1994
ABSTRACT Objectives Stage III non‐small cell lung cancer (NSCLC) treatment remains challenging, with a multitude of options available. We assessed IIIA NSCLC outcomes by received. Methods performed single‐institution retrospective review patients disease treated January 01, 2010—March 2022. Demographics, treatments, outcomes, and failure patterns were collected. Progression‐free survival (PFS) overall (OS) using Kaplan–Meier analysis. Failure for differences chi‐square Results Of 270...
ABSTRACT Objective Dual checkpoint inhibitor therapy with nivolumab and ipilimumab has been FDA approved for a number of cancer sites. However, its role in the treatment ACC non‐ACC salivary gland carcinomas (non‐ACC SGC) is not well established. Methods Analysis We performed Simon's two‐stage prospective single‐institution Phase II clinical trial ipilimumab. Two cohorts were analyzed: patients metastatic/recurrent SGC. The primary endpoint was median progression‐free survival (PFS);...
ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism provides nucleocytosolic acetyl-CoA necessary for protein acetylation. ACLY has two major splice isoforms: the full-length canonical "long" isoform an uncharacterized "short" in which exon 14 is spliced out. Exon encodes 10 amino acids within a disordered region of includes at least 1 site that dynamically phosphorylated. Both isoforms are expressed healthy tissues to varying degrees. Analysis human transcriptomic data revealed...
Abstract Introduction: Dual checkpoint inhibitor therapy with nivolumab and ipilimumab has been FDA-approved for a number of different cancers including melanoma, recurrent NSCLC, hepatocellular carcinoma. However, their role in the treatment ACC other salivary gland carcinomas is not well established. Methods: We performed Simon’s two-stage prospective single-institution phase II clinical trial (240 mg intravenously every 2 weeks 16 weeks, then 480 4 weeks) (1 mg/kg 6 weeks), both which...
Abstract Objective Dual checkpoint inhibitor therapy with nivolumab and ipilimumab has been FDA-approved for a number of cancer sites. However, their role in the treatment ACC other salivary gland carcinomas is not well established. Methods analysis We performed Simon’s two-stage prospective single-institution phase II clinical trial ipilimumab. Two cohorts were analyzed: patients metastatic/recurrent cancers. The primary endpoint was median progression-free survival (PFS); secondary...
3069 Background: Globally, cancer results in 10.08 million deaths per year. A single blood-based screening tool that detects multiple types could significantly reduce burden. We systematically reviewed and statistically examined both the accuracy applicability of MCED tests to strategize their utilization improving detection. Methods: Original articles were searched from PubMed, Cochrane, Embase for analyzing asymptomatic human subjects. excluded studies with small sample sizes (n<30),...
Abstract Background Those experiencing houselessness rely on obtaining food from community organizers and donations. Simultaneously, the houseless face disproportionally high rates of medical conditions that may be affected by diet including diabetes, hypertension, hyperlipidemia. There is limited literature resources barriers regarding optimal nutrition an actionable perspective. Further, less data available how street medicine organizations best impact unhoused they serve. Elucidating this...
Invasive mucinous adenocarcinoma (IMA) of lung is a unique subset adenocarcinomas characterized by an intrapulmonary aerogenous spread resulting in multicentric, multilobar, and bilateral lesions with low frequency distant metastasis. The treatment options for IMA are limited, advanced has poor prognosis, median survival less than year. Lung transplantation performed handful selected patients showed improved outcomes clinical improvement. However, high postoperative recurrence rates have...
Introduction:Hedysarum Multijugum Maxim (HMM), a Chinese traditional medicine , exerts anti-tumor effects and has been extensively studied for its potential to treat cancer in recent years. Clinical research shown that HMM can control hepatocellular cancer, but the exact molecular mechanism is unclear. Methods: To identify principal bioactive constituents of their corresponding targets, we constructed protein-protein interaction (PPI) network. Secondly, Cytoscape software was utilized...
Abstract Background: Globally, cancer results in 10.08 million deaths per year. A single blood-based screening tool that detects multiple types could greatly reduce burden. We aim to systematically review and statistically examine both the accuracy applicability of MCED tests strategize their utilization improving detection. Methods: Original articles were searched from Pubmed, Cochrane, Embase for analyzing asymptomatic human subjects. excluded studies with small sample size (n&lt;30),...
This review article focuses on the field of epigenetics.Since its inception in 20th century, there have been several major developments which induced change what word "epigenetics" actually meant.In this review, discoveries made so far are summarised and potential applications these new discussed.Some things to keep mind that epigenetics is relatively young compared many other fields research, bound be areas understanding topic lacking.Despite this, partly due recent advances technology,...
Background: Globally, cancer results in 10.08 million deaths per year. A single blood-based screening tool that detects multiple types could reduce burden. We systematically review and statistically examine both the accuracy applicability of multi-cancer early detection (MCED) tests to strategize their utilization improving detection.Methods: Original articles were searched from Pubmed, Cochrane, Embase for tests, types, asymptomatic human subjects. excluded studies with small samples...
Abstract Introduction: ATP-citrate lyase (ACLY) links carbohydrate and lipid metabolism as well provides acetyl-CoA necessary for histone acetylation, linking cell nutrient status epigenetic regulation. Several studies have shown that ACLY is upregulated in multiple cancer types. has two major splice isoforms: the full-length canonical “long” isoform an uncharacterized “short” where exon 14 spliced out. RNAseq data from The Cancer Genome Atlas (TCGA) shows Percent Spliced In (PSI) of 14,...
Abstract Background: Among the recently developed blood-based multi-cancer early detection (MCED) tests, determining location of tumors is pivotal to guiding appropriate treatment. We aim systematically review and statistically examine accuracy tumor origin prediction among MCED tests. Methods: Original articles were searched from Pubmed, Cochrane, Embase that featured screening multiple cancer types, asymptomatic human subjects. excluded studies with small samples (n&lt;30),...
e15053 Background: Among recently developed blood-based MCED tests, the ability to determine location of tumors is pivotal guiding appropriate treatment. We systematically reviewed and statistically examined accuracy tumor origin predictions among tests. Methods: Original articles were searched from Pubmed, Cochrane, Embase for screening multiple cancer types, asymptomatic human subjects. excluded studies with small samples (n < 30), non-screening, non-blood-based For cfDNA-based assays,...
<h3>Background</h3> Hyperprogressive disease (HPD) is the acceleration of tumor growth observed in patients treated with immunotherapy. HPD was seen to be negatively associated overall survival (OS) and progression-free (PFS) when compared without HPD.<sup>1–5</sup> Various definitions have been used evaluate relationship between OS/PFS.<sup>2,6–11</sup> This study uses two from Champiat Saada-Bouzid et al. association OS/PFS lung cancer patients.<sup>8,11</sup> <h3>Methods</h3>...