A5108013371- Cancer Genomics and Diagnostics
- Drug Transport and Resistance Mechanisms
- Renal and related cancers
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
University of Pecs
2017-2020
Type 2 alveolar epithelial cells (AT2s) behave as stem and show clonal proliferation upon injury followed by trans-differentiation (TD) into 1 (AT1s). In the present study we identified signaling pathways involved in physiological AT2-to-AT1 TD process. AT2 can be isolated from human lungs cultured vitro where they undergo AT1s. process using Affymetrix microarray, qRT-PCR, fluorescence microscopy, an lung aggregate culture. microarray revealed Wnt to play a crucial role Wnt7a was ligand...
Background Despite improved screening techniques, diagnosis of lung cancer is often late and its prognosis poor. In the present study, in vitro chemosensitivity solid tumours pleural effusions adenocarcinomas were analysed compared with clinical drug response.Methods Tumour cells isolated from resected or effusions, cryopreserved. Three-dimensional (3D) tissue aggregate cultures set up when oncoteam reached therapy decision for individual patients. The aggregates then treated selected...