Abstract Peroxidase (POD) Nanozyme‐based hydrogen peroxide (H 2 O ) detection is popular, but hardly adapt to high concentration of H owing narrow linear range (LR) and low LR maximum. Here, a solution combining POD catalase (CAT) raised expand the assay via decomposing part . As proof concept, cascade enzyme system (rGRC) constructed by integrating ruthenium nanoparticles (RuNPs), CAT graphene together. The rGRC‐based sensor does perform an expanded higher maximum for detection. Meanwhile,...

Pathological mucus hypersecretion is an important clinical hallmark of chronic airway inflammatory diseases and yet there a lack effective therapeutic medicine. Resveratrol, dietary polyphenol, has been shown to possess anti‑aging, antioxidation, anti‑inflammation tumor prevention effects. However, the effect underlying mechanism resveratrol in lipopolysaccharide (LPS) induced‑mucus remain be elucidated. Among more than 20 mucin family members, 5ac (MUC5AC) major glycoprotein mucus. The...

Background Xuebijing (XBJ) is a traditional Chinese medicine widely used in China for managing sepsis, systemic inflammatory response syndrome, and multiple organ dysfunction secondary to severe infections. This study aimed assess the therapeutic efficacy safety of XBJ as an adjuvant treatment Acinetobacter baumannii ( A. ) infections through meta-analysis, explore its potential mechanisms via integrated pharmacological approaches. Materials methods A systematic search was conducted across...

Abstract Diabetic retinopathy (DR) is a common diabetic complication known to cause vision impairment and blindness. Previous studies have demonstrated that proanthocyanidins (PACs), polyphenols are naturally found in several plants fruits, powerful antioxidant anti‐inflammatory effects on various cells. However, the underlying mechanism of PACs against DR pathogenesis remain unknown. Here, we investigated proliferation, apoptosis, mechanisms ARPE‐19 cells response oxidative stress...

AIM: To evaluate the effects of panretinal photocoagulation (PRP) compared with PRP plus intravitreal bevacizumab (IVB) in patients high-risk proliferative diabetic retinopathy (PDR) according to Early Treatment Diabetic Retinopathy Study criteria. METHODS: The data were collected retrospectively from eyes PDR patients, which divided into two groups. After treated standard PRP, randomly assigned receive only (PRP group) or injection 1.25 mg (PRP-Plus group). Patients underwent complete...

The purpose of this study was to investigate the correlation between insulin and Fetuin-B (FETUB) influence FETUB on signaling pathway in diabetic retinopathy (DR).

To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of tafluprost 0.0015% eye drops [benzalkonium chloride (BAK) 0.1 mg/mL] compared with that latanoprost 0.005% (BAK 0.2 mg/mL) for primary open angle glaucoma (POAG) ocular hypertension (OHT).All randomized controlled trials (RCTs) about treating POAG OHT comparing were collected by searching PubMed, Embase, Cochrane Library, CNKI VIP. The outcomes interest to clinical adverse effects included IOP patient-related drop...

Posterior capsular opacification (PCO) is the main complication following cataract surgery. The proliferation of residual lens epithelial cells (LECs) serves an important role in PCO formation. authors' previous study revealed that vitamin C inhibited human LECs by increasing rapid degradation hypoxia‑inducible factor‑1 (HIF‑1α), and hence expression vascular endothelial growth factor (VEGF). present aimed to further investigate mechanisms underlying effects on levels VEGF. demonstrated...

Diabetic retinopathy (DR) causes irreversible visual impairment in diabetes mellitus (DM) patients. Immunity played a crucial role DR. Nevertheless, the triggering mechanism of DR was not yet thorough enough. Herein, we aim to identify immune-associated genes as biomarkers associated with immune scores that can distinguish early from DM without DR.In this study, total RNA peripheral blood mononuclear cell (PBMC) samples 15 non-proliferative patients and were collected transcriptome...

AIM: To evaluate the inhibitive effect of olmesartan to fibroblast proliferation and anti-scarring in Tenon’s capsule, both vitro vivo. METHODS: Human primary capsule fibroblasts were cultured vitro, treated with up titrating concentrations olmesartan. The rate inhibition was tested methyl thiazol tetrazolium (MTT) method. Real-time PCR performed analyze changes mRNA expressions fibrosis-related factors: matrix metalloproteinase-2 (MMP-2), tissue inhibitor metalloproteinase (TIMP-1,2)...

Purpose To investigate the expression, source, role, and mechanism of Fetuin-B (FETUB) in diabetic retinopathy (DR).

Abstract The rising costs of cancer care and subsequent medical financial hardship for survivors families are well documented in the United States. Less attention has been paid to employment disruptions loss household income after a diagnosis during treatment, potentially resulting lasting hardship, particularly working‐age adults not yet age‐eligible Medicare coverage their families. In this article, authors use composite patient case illustrate adverse consequences treatment employment,...

Abstract Background SD-OCT is becoming commonplace in everyday practice. Vitreomacular adhesions (VMAs) are being more routinely diagnosed. Predictive studies to the natural course of VMA thus clinically significant. Spectral domain-optical coherence tomography (SD-OCT) was presently utilized analyze incidence floaters, complete vitreomacular separation or VMA, complication, angle (VMAng), and complication mechanism. Methods Monthly performed on patients with/without symptomatic floaters....

Aim. Pirfenidone (PFD), an antifibrotic drug, has various beneficial functions such as antioxidant, antifibrotic, and anti-inflammatory effects. This study aimed to explore the molecular mechanisms underlying how PFD modulates retinal pigment epithelial (RPE) cells involved in neovascularization subretinal fibrosis. Methods. ARPE-19 cell lines were treated with transforming growth factor-beta 2 (TGF-β2) alone or combination PFD. RPE viability, a consequence of use, was determined by CCK-8...

To compare visual performance and quality outcomes after phacoemulsification with two different clear corneal incision (CCI) distances anterior to the limbus in senile cataract patients.Retrospective case series. Patients who had undergone were divided into groups according CCI limbus. The group A range from 1 mm 1.5 mm, while those B 0.5 mm. acuity, refraction, surgically induced astigmatism (SIA), aberrations, segment parameters, subjective vision evaluated.This study enrolled 54 eyes, 27...

Purpose. To investigate the efficacy of idiopathic macular pucker (epimacular membrane) surgery and to identify possible prognostic factor. Methods. This was a retrospective study which enrolled 38 patients with who underwent 23-gauge pars plana vitrectomy (PPV) indocyanine green-assisted peeling epiretinal membrane (ERM) internal limiting (ILM). Visual outcomes were assessed at baseline during follow-up including best-corrected visual acuity (BCVA) metamorphopsia score, as well outer...