A5113751648- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Systemic Lupus Erythematosus Research
- Allergic Rhinitis and Sensitization
- Toxin Mechanisms and Immunotoxins
- Cytokine Signaling Pathways and Interactions
- Biological Activity of Diterpenoids and Biflavonoids
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Advancements in Transdermal Drug Delivery
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Hair Growth and Disorders
- Eosinophilic Disorders and Syndromes
- CAR-T cell therapy research
- Nail Diseases and Treatments
- Autoimmune and Inflammatory Disorders
- Wound Healing and Treatments
- Antenna Design and Analysis
- Nonmelanoma Skin Cancer Studies
- Reproductive System and Pregnancy
- Systemic Sclerosis and Related Diseases
- Retinoids in leukemia and cellular processes
- Neonatal skin health care
Southern Medical University
2016-2025
Zhongshan Hospital
2022
Fudan University
2016-2022
Third Affiliated Hospital of Zhengzhou University
2022
Beijing Hospital
2021
Zhujiang Hospital
2011-2020
Third Affiliated Hospital of Southern Medical University
2020
Inner Mongolia University for Nationalities
2019
Nanjing Drum Tower Hospital
2018
Huashan Hospital
2016
Background: Amphotericin B (AMB) is a polyene antibiotic with broad spectrum antifungal activity, but its clinical toxicities and poor solubility limit the wide application of AMB in practice. Recently, new drug-loaded nanoparticles (NPs) – diblock copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) (PLGA-TPGS) have received special attention for their reduced toxicity, increased effectiveness drug has also been reported. This study aimed to...
Atopic dermatitis (AD) is a common inflammatory skin disease with high rates of morbidity and associated erythema, pruritus, scaling affected areas skin. It extremely important to introduce therapeutic agent which has significant anti-inflammatory effect less side-effect for treatment AD. This study evaluated the natural compound from herbal extracts, crude polysaccharide extracted white wax scale (CWPS), on AD-like mice. Repeated applications 2,4-dinitrochlorobenzene (DNCB) were performed...
Purpose: Melanoma is the most aggressive and life-threatening cutaneous cancer. To explore new treatment strategies, it essential to identify mechanisms underlying melanoma tumorigenesis metastasis. Methods: In current study, we demonstrated altered expression of long non-coding RNA (lncRNA) messenger (mRNA) in using data from Cancer Genome Atlas (TCGA) database. Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) enrichment, protein-protein interaction (PPI) analyses were conducted....
Acitretin has been a valuable option for the treatment of psoriasis, however, molecular events acitretin leading to normalization keratinocytes differentiation on psoriasis patients have not fully explored. To investigate whether there were certain relationship between proliferation and JAK/STAT signaling pathways in how modulated pathways. HaCaT cells, an vitro immortal human keratinocyte cell line, was chosen as model psoriasis. The small interfering RNA targeting STAT1 (siRNA-STAT1) STAT3...
Abstract Atopic dermatitis (AD) is a common chronic inflammatory skin disease that often associated with barrier dysfunction leading to higher frequency of bacterial and viral infections. Toll‐like receptor (TLR) 4 on resident cells was involved in sensing pathogens eliciting pathogen‐specific innate adaptive immune responses. Previous studies have demonstrated TLR4 linked AD severity context pathogen infection. However, the regulatory role remains be defined. We here investigated function...
Psoriasis is an autoimmune disease, which characterized by aberrantly high levels of inflammation, but the underlying pathogenic mechanisms are still not fully understood. Signal transducer and activator transcription 1 (STAT1) STAT3, downstream proteins suppressor cytokine signaling (SOCS1) SOCS3, have been implicated in psoriasis disease progression. Calcipotriol, a synthetic derivative vitamin D, has used clinically to treat psoriasis, mechanism action that underlies beneficial effects...
Abstract Psoriasis is a chronic, relapsing inflammatory skin disorder. Numerous experimental evidence and therapeutic have shown that the innate immune response critical for pathogenesis development of psoriasis. Mannan‐binding lectin (MBL), prototypic pattern recognition molecule system, plays an essential role in host defense against certain infections also appears to be major regulator inflammation. In this study, we investigated function MBL on course murine imiquimod (IMQ)‐induced Our...
A 76-year-old woman has got both lower limbs petechia and ecchymosis for 1 month, edema 6 days fever 3 days. The patient suffered from purpura of limbs, edema, arthralgia, recurrent fever, kidney damages, serositis, progressive
Abstract Hemangioma is a common benign tumour that usually occurs on the skin of head and neck, particularly among infants. The current clinical treatment against hemangioma surgery excision, however, application drug safer more economical therapy for children suffering from hemangioma. As natural sulfated polysaccharide rich in brown algae, fucoidan widely recognized anti‐tumour bioactivity dosage safety humans. This study aims to demonstrate effect underlying mechanism vivo vitro. We...
Plaque‐type blue naevus (PTBN) is a very rare variant of (BN). The potential malignancy subcutaneous cellular nodules (SCN) in PTBN was discovered 2012, and there currently no clear consensus on prognostic factors or management guidelines such lesions. the scalp have not been described literature. We report clinical, histopathological immunohistological features 50‐year‐old man who presented with 30‐year history PTBN, malignant proliferation nodular elements fatal outcome 8 years later. This...