A5092793426- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Thermal Regulation in Medicine
- Heat shock proteins research
- Immune Response and Inflammation
Vanderbilt University Medical Center
2024
Vanderbilt University
2023
Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased murine CD4 T cell metabolism, proliferation, and inflammatory effector activity while decreasing regulatory suppressive capacity. However, heat-exposed helper 1 (T H 1) selectively developed mitochondrial stress DNA damage activated Trp53 stimulator interferon genes pathways. Although many subjected to such died, surviving exhibited...
Abstract PD-1 blockade has been approved for head and neck squamous cell carcinoma (HNSCC) patients. However, many HNSCC patients do not respond to this treatment, other tumor microenvironmental factors may promote resistance blockade. We previously identified increased expression of the inhibitory receptor NKG2A on CD8+ T cells in tumors compared with matching PBMC samples. Mechanisms that role human microenvironment, however, are uncertain. In study, we show tumor-conditioned media (TCM)...
Abstract PD-1 blockade has been approved for head and neck squamous cell carcinoma (HNSCC) patients. However, only about 20% of HNSCC patients respond to blockade. We hypothesize that other inhibitory receptors play a role as resistance mechanism Our laboratory others found the NKG2A/HLA-E pathway is overexpressed in NKG2A an receptor expressed by NK cells CD8 +T cells. How expression regulated on human T not clear. Additionally, we previously identified significant increase tumors when...