A5017435081- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Statistical Methods in Clinical Trials
- Advanced Causal Inference Techniques
- Potassium and Related Disorders
- Colorectal Cancer Treatments and Studies
- Mechanical Circulatory Support Devices
- Glycosylation and Glycoproteins Research
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Diabetes Treatment and Management
- Pregnancy-related medical research
- Sarcoidosis and Beryllium Toxicity Research
- Erythropoietin and Anemia Treatment
- Renin-Angiotensin System Studies
- Cancer Treatment and Pharmacology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Cardiac Structural Anomalies and Repair
- Cancer Genomics and Diagnostics
- Chronic Disease Management Strategies
- Apelin-related biomedical research
- Health Systems, Economic Evaluations, Quality of Life
Cytel (United States)
2024
Bristol-Myers Squibb (United States)
2024
Momentum Research
2014-2021
Merck (Germany)
2010-2011
Marqués de Valdecilla University Hospital
2010
Universitat de València
2010
Universitat Autònoma de Barcelona
2010
Background: The importance of a serum creatinine increase, traditionally considered worsening renal function (WRF), during admission for acute heart failure has been recently debated, with data suggesting an interaction between congestion and changes. Methods Results: In post hoc analyses, we analyzed the association WRF length hospital stay, 30-day death or cardiovascular/renal readmission 90-day mortality in PROTECT study (Placebo-Controlled Randomized Study Selective A1 Adenosine Receptor...
Idiopathic pulmonary fibrosis is a fatal and progressive disease with limited treatment options.
Reports are mixed on the efficacy of omega-3 fatty acids (O3FA) for treatment major depressive disorder (MDD), with only limited data in adolescents. The present trial aimed to investigate systematically O3FA as a monotherapy, compared placebo, adolescents MDD. Secondarily, we explored effects anhedonia, irritability, and suicidality-all key features adolescent MDD.Fifty-one psychotropic medication-free DSM-IV-TR diagnoses MDD (aged 12-19 years; 57% female) were randomized receive or placebo...
Abstract Aims This study aims to explore long‐term clinical outcomes of cardiopoiesis‐guided stem cell therapy for ischaemic heart failure assessed in the Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART‐1) trial. Methods and results CHART‐1 is a multinational, randomized, double‐blind trial conducted 39 centres patients ( n = 315) on standard‐of‐care therapy. The ‘active’ group received cardiopoietic cells delivered intramyocardially using retention‐enhanced catheter....
Preliminary safety findings are presented from the open-label Phase I part of a combined I/II study BLP25 liposome vaccine (L-BLP25) in Japanese patients with unresectable Stage III non-small-cell lung cancer after primary chemoradiotherapy. Six received four or more once-weekly vaccinations L-BLP25 1000 μg subcutaneously prior to preliminary evaluation. Treatment continued until week 8, then maintenance every 6 weeks progressive disease. Cyclophosphamide (300 mg/m2 i.v. single dose) was...
e13153 Background: The innovative cancer vaccine L-BLP25 (Stimuvax; BLP25 liposome vaccine) targets the MUC1 tumor-associated antigen. tolerability is acceptable and Caucasian patients with stage IIIB locoregional non-small cell lung (NSCLC) who are treated tend to survive longer. We report preliminary safety data from an open-label, nonrandomized phase I study combined a double-blind, randomized, placebo-controlled II study. Methods: Phase comprises administering 6 unresectable III NSCLC...
Abstract Aims All phase 3 studies in patients with acute heart failure (AHF) and HF preserved ejection fraction (HFpEF) have failed the last decades. We explore likelihood that negative results are due to chance and/or study size dilution of statistical power. Methods First, using simulations, we examined probability a positive finding 2 would result studying truly effective drugs 3. simulated under six scenarios where range true relative risk (RR) for an outcome interest varied from 0.5...