A5102925864- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Tracheal and airway disorders
- Effects of Radiation Exposure
- Nasal Surgery and Airway Studies
- Voice and Speech Disorders
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Monoclonal and Polyclonal Antibodies Research
- Reconstructive Surgery and Microvascular Techniques
- Dysphagia Assessment and Management
- melanin and skin pigmentation
- Indoor Air Quality and Microbial Exposure
- Reconstructive Facial Surgery Techniques
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Airway Management and Intubation Techniques
- Comparative Animal Anatomy Studies
- Virus-based gene therapy research
- Hematopoietic Stem Cell Transplantation
- Head and Neck Anomalies
- Salivary Gland Tumors Diagnosis and Treatment
University of Alabama at Birmingham
2024
Tenwek Hospital
2024
Ochsner Health System
2008-2024
Henry Ford Health System
2024
The University of Queensland
2016-2024
Ochsner Medical Center
2003-2023
Digital Research Alliance of Canada
2021
Psoriasis Association
2021
Loyola University Medical Center
2020
University of California, Los Angeles
1965-2020
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular (Tfh) cell, has emerged as key immunoregulator germinal center (GC) formation and high-affinity antibody production. To identify pathophysiological role Tfh cells in SLE patients, we compared phenotypic functional properties circulating Tfh-like patients to GC-Tfh cells, correlated percentage with autoantibody...
Abstract One hundred eighty‐two patients were evaluated after functional endoscopic sinus surgery. The goal was to establish whether any anatomical finding correlated with symptoms and find historical predictors of symptomatic failure. Of all physical findings reviewed, only scarring middle meatal antrostomy the ethmoids approached significance in predicting poor outcome. Surprisingly, factors gastroesophageal reflux disease statistically significant as a predictor
Twenty asthma patients who underwent functional endoscopic sinus surgery for chronic sinusitis were studied. Medical records and questionnaire data these 20 studied regarding the impact of disease on their asthma. We found that 95% reported was worsened by (95% confidence interval, 0.74 to 0.99+), 85% improved (0.60 0.97). Of 13 used both inhalers systemic medication, 53.8% able eliminate some medication (0.21 0.79). Furthermore, 61.5% had a concomitant reduction in inhaler use (0.28 0.85)....
A total of 283 consecutive patients with chronic sinusitis underwent functional endoscopic sinus surgery. There were 72 allergic and 211 nonallergic patients. Data collected on the effect immunotherapy middle meatotomy patency, synechiae formation, recurrent polyps in supported following conclusions: (1) Immunotherapy given either before or after surgery does not statistically influence recurrence However, data do suggest, for all three outcome parameters, that who undergo better than those...
Endoscopic sinus surgery has gained acceptance in the otolaryngologic community as an effective and safe method of treating inflammatory disease paranasal sinuses. At our institution, partial endoscopic middle turbinectomy become a standard component procedure experience is reported. Middle enhances surgical exposure, specific anatomic anomalies are more completely corrected, subpopulations patients at risk for failure because their underlying enjoy decreased rates synechiae formation...
Damage to the recurrent laryngeal nerve is a frequently seen complication in head and neck surgery. A system for intraoperative monitoring of presented. The key this lies use microlaryngeal electrode inserter. Application various situations described.
A series of 145 patients with chronic sinusitis were treated functional endoscopic sinus surgery. Patency the middle meatus was evaluated by actuarial life-table methods. After 24 months' follow-up, overall patency rate meatotomy 94.08%. Questionnaire data indicated that 91.8% these improved or asymptomatic. This preliminary study indicates meatal antrostomy appears to be greater than inferior when compared literature controls, and a high percentage are this
Two hundred patients with chronic sinusitis were operated on using functional endoscopic sinus surgery (FESS) techniques. These followed closely over 3 years. Patency of the middle meatotomy was recorded actuarial life-table methods. The overall patency rate 93.55%, and at 36 months 87.47%. presence seasonal allergy nasal polyps most important variable in predicting closure. Middle turbinectomy patency. Symptoms evaluated by questionnaire 1 year. Questionnaire data indicate that 96% these...
Studies have been performed on a 12-yr-old Chinese girl with compensatory erythrocytosis due to the presence of hemoglobin Bethesda comprising about 45% red cell hemoglobin. Her parents and three siblings were normal. The oxygen affinity her blood was markedly increased: under physiological conditions (pH 7.40, 37 degrees C). P(50) 12.8 mm Hg (normal = 26.5 Hg). 2,3-diphosphoglycerate (2.3-DPG) level abnormal could not be separated from A by zone electrophoresis at pH 8.6 or isoelectric...
Eighteen patients were operated on by functional endoscopic sinus surgery who had no ostiomeatal unit obstruction computed tomography scan and unremarkable paranasal sinuses. These also apparent diagnostic nasal endoscopy. Data collected these regarding the impact of very limited their principal complaint recurrent sinusitis with facial pain/headache thought to be sinogenic origin. Sixteen (88.9%) a reduction in number infections requiring antibiotic therapy. This was significant at p <...
A new isotope dilution gas chromatography/chemical ionization/tandem mass spectrometric method was developed for the analysis of carcinogenic hydrazine in drinking water. The sample preparation performed by using optimized derivatization and multiple liquid-liquid extraction techniques. Using direct aqueous-phase with acetone, isotopically labeled hydrazine-(15)N2 used as surrogate standard formed acetone azine azine-(15)N2, respectively. These derivatives were then extracted...
Abstract Most laryngeal anomalies are supraglottic and laryngomalacia is the most common. Cysts, bifid epiglottis absence of uncommon. An 18‐year‐old Caucasian man had long‐standing stridor caused by anomalous structures: a small floppy epiglottis, enlarged accessory cartilages redundant aryepiglottic folds. These structures were excised airway was improved. The ventral portions fourth arches become folds lateral segments epiglottis. A disturbance in this portion arch may explain anomaly....
Electrodes were placed into the posterior cricoarytenoid and diaphragmatic muscles of five tracheostomized dogs. With use a sensor that would selectively detect electromyographic activity, this activity served as trigger was amplified interfaced with muscle stimulator attached to electrodes in muscles. In all animals obvious physiologic synchrony vocal fold abduction reduction negative inspiratory intratracheal pressure observed during electrical pacing. This represents preliminary step...
Endoscopic partial inferior turbinoplasty with a microdebrider has been introduced as an alternative to other turbinectomy techniques for the treatment of nasal airway obstruction. Between June 1994 and December 1997, 100 patients underwent endoscopic turbinoplasty. Concurrent septoplasty was performed in 81 patients, functional sinus surgery 43 patients. Synechiae formation 12 most common complication resolved nearly all cases. Postoperative improvement patency occurred 93% In 48 whom...
Although the majority of patients receiving erythromycin experience no hearing loss, certain are susceptible. Erythromycin ototoxicity data were analyzed on 20 from 13 reports in English language literature as well two University Missouri-Columbia. Patients classified with respect to age, sex, premorbid diagnosis, renal/hepatic function, type used, dosage, duration therapy, and route administration. The following auditory effects considered: onset symptoms, degree configuration recovery...
Abstract Tracheostomy tube fracture with subsequent migration of the proximal fragment down tracheobronchial tree is an almost unheard cause tracheal foreign bodies. Most such occurrences have been reported outside United States, and only six previous reports filed. We report additional case fractured tracheostomy review literature.
SLE is an autoimmune disease characterised by persistent inflammation and autoantibody production. Genetic predisposition environmental factors such as a high-fat diet (HFD) may contribute to lupus development. However, the immune cell profile gender difference in response HFD have not been reported. Here we investigated impact of on pathogenesis autoimmunity using lupus-prone mice.Thirty male 30 female MRL/lymphoproliferation (lpr) mice were fed with regular (RD) or HFD. Body weights...
Twenty-nine consecutive patients with cystic fibrosis were offered functional endoscopic sinus surgery. Twenty-six of these underwent A symptom questionnaire was obtained from the patient or parent before At end study this again administered to same individual, and 21 completed it. There 14 male 7 female patients, a mean age 12.3 years median 8.7 years. Mean follow-up 34.3 months. Results for following symptoms significant: nasal airway obstruction improved (p < 0.0002), olfactory function...