A5028348673- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
National Center for Tumor Diseases
2025
Universidade de São Paulo
2019-2022
Colorectal cancer (CRC) ranks as the third most commonly diagnosed worldwide and is second leading cause of cancer-related mortality. Recent studies have highlighted critical role long non-coding RNAs (lncRNAs) in CRC development, influencing processes such proliferation, invasion, therapy resistance. However, functional roles annotated lncRNAs remain poorly understood, underscoring need to uncover novel that may impact initiation, progression, treatment response. To identify involved cell...
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are essential players in the regulation of gene expression. The majority twenty different hnRNP proteins act through modulation pre-mRNA splicing. Most have been shown to regulate expression critical genes for progression tumorigenic processes and were also observed be overexpressed several types cancer. Moreover, these described as components maturation some microRNAs (miRNAs). In human genome, over 70% miRNAs transcribed from introns;...